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  1. 75701
    “…Furthermore, our work has revealed a substantial heterogeneity in seeding activity, driven by the PBS-soluble α-synuclein, between different brain regions of a given individual that goes beyond immunohistochemical observations. Our observations pave the way for future subclassification of MSA, which exceeds conventional clinical and neuropathological phenotyping and considers the structural and biochemical heterogeneity of α-synuclein present. …”
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    Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
  2. 75702
    “…The experience of childhood adversity can have a lasting impact into and beyond the prenatal period, potentially increasing the risk of preterm birth, even among otherwise healthy women. …”
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    Maternal adverse childhood experiences and their association with preterm birth: secondary analysis of data from universal health visiting
  3. 75703
    “…In SPPB, gait speed, 30s CST, and LLFDI-FC, 21–56% of participants did not change their scores beyond the Minimal Clinically Important Difference (MCID). …”
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    Feasibility of performance-based and self-reported outcomes in self-managed falls prevention exercise interventions for independent older adults living in the community
  4. 75704
    “…Evaluating vaccine efficacy or effectiveness beyond 6 months will be crucial for updating COVID-19 vaccine policy. …”
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    Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression
  5. 75705
    por Jandhyala, Ravi
    Publicado 2022
    “…The decrease in the quality of life scores was only statistically significant (p = 0.037) for SEIQoL(visit_cues). Beyond the baseline visit, the only highly positive and statistically significant pairwise association was between SEIQoL(visit_cues) and SEIQoL(baseline_cues) at M6 (ρ = 0.782, P value < 0.05) and M9 (ρ = 0.879, P value < 0.05). …”
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    Concordance between the schedule for the evaluation of individual quality of life-direct weighting (SEIQoL-DW) and the EuroQoL-5D (EQ-5D) measures of quality of life outcomes in adults with X-linked hypophosphatemia
  6. 75706
    “…The DAP fosters freedom to expand beyond study-supported strategies. Qualitative data illuminate motives for strategy diversification, such as improving EIP fit. …”
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    Amplification of school-based strategies resulting from the application of the dynamic adaptation process to reduce sexual and gender minority youth suicide
  7. 75707
    por Rodríguez-Flores, Marcela, Goicochea-Turcott, Eduardo W., Mancillas-Adame, Leonardo, Garibay-Nieto, Nayely, López-Cervantes, Malaquías, Rojas-Russell, Mario E., Castro-Porras, Lilia V., Gutiérrez-León, Eduardo, Campos-Calderón, Luis F., Pedraza-Escudero, Karen, Aguilar-Cuarto, Karina, Villanueva-Ortega, Eréndira, Hernández-Ruíz, Joselin, Guerrero-Avendaño, Guadalupe, Monzalvo-Reyes, Sheyla M., García-Rascón, Rafael, Gil-Velázquez, Israel N., Cortés-Hernández, Dora E., Granados-Shiroma, Marcela, Alvarez-Rodríguez, Brenda G., Cabello-Garza, Martha L., González-Contreras, Zaira L., Picazo-Palencia, Esteban, Cerda-Arteaga, Juana M., Pérez-Gómez, Héctor R., Calva-Rodríguez, Roberto, Sánchez-Rodríguez, Gerardo, Carpio-Vázquez, Leslie D., Dávalos-Herrera, María A., Villatoro-de-Pleitez, Karla M., Suárez-López, Melissa D., Nevárez-Carrillo, María G., Pérez-Alcántara, Karina, Mehta, Roopa, Diez, Edurne Sandoval, Gregg, Edward W.
    Publicado 2022
    “…CONCLUSIONS: EOSS was associated with adverse COVID-19 outcomes, and it distinguished risks beyond BMI. Patients with overweight and obesity in EOSS stages 0 and 1 had a lower risk than patients with normal weight. …”
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    The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study
  8. 75708
    “…Limitations of this study included confounding due to unmeasured factors, unavailable information on gabapentinoids’ indication, potential misclassification, and limited generalizability beyond older adults insured by Medicare FFS program. …”
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    Concurrent use of prescription gabapentinoids with opioids and risk for fall-related injury among older US Medicare beneficiaries with chronic noncancer pain: A population-based cohort study
  9. 75709
    “…Assessing perinatal outcomes associated with food consumption score is essential for unraveling the spectrum of nutrition in pregnancy and beyond.…”
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    Factors associated with food consumption score among pregnant women in Eastern Ethiopia: a community-based study
  10. 75710
    “…An acute increase in the number of hospitalized patients has necessitated a rigorous reorganization of hospital care, thereby creating circumstances that previously have been identified as facilitating prescribing errors (PEs), e.g. a demanding work environment, a high turnover of doctors, and prescribing beyond expertise. Hospitalized COVID-19 patients may be at risk of PEs, potentially resulting in patient harm. …”
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    Prescribing errors in post - COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post - COVID-19 outpatient clinic
  11. 75711
    “…In all scenarios, it was estimated to be cost-effective to maintain face mask use for about 2–10 weeks beyond the date that target vaccination coverage (70–90%) was achieved, with this added duration being longer when the target coverage was achieved during winter versus summer. …”
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    Maintaining face mask use before and after achieving different COVID-19 vaccination coverage levels: a modelling study
  12. 75712
    “…Long COVID is much less precisely defined and includes all the persistent or new clinical manifestations evidenced in subjects previously infected by SARS-CoV-2 beyond the period of the acute infection and that cannot be explained by an alternative diagnosis. …”
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    Italian intersociety consensus on management of long covid in children
  13. 75713
    “…Regular dental visits are also limited to one visit per year in many countries. Beyond financial barriers due to out-of-pocket payments, patients may experience very different physical barriers to accessing dental care. …”
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    Exploring variation of coverage and access to dental care for adults in 11 European countries: a vignette approach
  14. 75714
    “…Most studies on educational strategies, multimodal strategies and psychological strategies were associated with significant reductions in MEDs beyond 1 month. The majority of recommendations from clinical practice guidelines were of low level of evidence. …”
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    Strategies aimed at preventing long-term opioid use in trauma and orthopaedic surgery: a scoping review
  15. 75715
    “…In low- and middle-income countries (LMICs) (N = 16), tracing most frequently involved identification of LTFU from the electronic medical record (EMR) and paper records followed by a combination of telephone calls and field tracing (including home visits), by a team of outreach workers within 3 months of becoming LTFU (N = 7), with few incorporating additional strategies to support reengagement beyond contact (N = 2). In high-income countries (HICs) (N = 21 studies), LTFU were similarly identified through EMR systems, at times matched with other public health records (N = 4), followed by telephone calls and letters sent by mail or email and conducted by outreach specialist teams. …”
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    Interventions to reengage people living with HIV who are lost to follow-up from HIV treatment programs: A systematic review and meta-analysis
  16. 75716
    “…Neoadjuvant stereotactic body radiation therapy (SBRT) may help sterilize margins, but its additive benefit beyond neoadjuvant chemotherapy (nCT) is unclear. …”
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    Neoadjuvant Stereotactic Body Radiotherapy After Upfront Chemotherapy Improves Pathologic Outcomes Compared With Chemotherapy Alone for Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma Without Increasing Perioperative Toxicity
  17. 75717
    “…Based on the identified gaps, educating physicians on aspects of ITP beyond bleeding, and highlighting patients’ under-recognized symptoms/needs through support-systems should be prioritized in the future. …”
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    How do patients and physicians perceive immune thrombocytopenia (ITP) as a disease? Results from Indian analysis of ITP World Impact Survey (I-WISh)
  18. 75718
    “…However, recovery of the underlying signals/information in low-dose images beyond a quarter of the standard dose would not be feasible (due to very poor signal-to-noise ratio) which will adversely affect the clinical interpretation of the resulting images. …”
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    Deep learning–based denoising of low-dose SPECT myocardial perfusion images: quantitative assessment and clinical performance
  19. 75719
    “…This review shows that guaranteeing different experiences beyond sports, improving social inclusion, using innovative technologies, and providing adequate materials and spaces to be important challenges and ways to guide policies, programs, and new research in this field of knowledge. …”
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    Mapping recommended strategies to promote active and healthy lifestyles through physical education classes: a scoping review
  20. 75720
    “…BACKGROUND: Disc herniation refers to the displacement of disc material beyond its anatomical space. Disc sequestration is defined as migration of the herniated disc fragment into the epidural space, completely separating it from the parent disc. …”
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    Lumbar disc sequestration mimicking a tumor: Report of four cases and a literature review
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