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  1. 76021
    “…CONCLUSION: The employer‐sponsored disease management program provided a better understanding of migraine, promoted methods and approaches to improve management by combining medical and lifestyle options leading to significant improvements in migraine symptoms that sustained beyond the intervention, supporting prolonged effectiveness of such programs. …”
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    Employee and Employer Benefits From a Migraine Management Program: Disease Outcomes and Cost Analysis
  2. 76022
    “…Unfortunately, once liver metastasis occurs, patient prognosis is extremely poor with as few as 8% of patients surviving beyond two years. There are no standard-of-care therapies available for the treatment of metastatic UM, hence it is a clinical area of urgent unmet need. …”
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    High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells
  3. 76023
    por Kanis, John A, Johansson, Helena, McCloskey, Eugene V, Liu, Enwu, Åkesson, Kristina E, Anderson, Fred A, Azagra, Rafael, Bager, Cecilie L, Beaudart, Charlotte, Bischoff-Ferrari, Heike A, Biver, Emmanuel, Bruyère, Olivier, Cauley, Jane A, Center, Jacqueline R, Chapurlat, Roland, Christiansen, Claus, Cooper, Cyrus, Crandall, Carolyn J, Cummings, Steven R, da Silva, José AP, Dawson-Hughes, Bess, Diez-Perez, Adolfo, Dufour, Alyssa B, Eisman, John A, Elders, Petra JM, Ferrari, Serge, Fujita, Yuki, Fujiwara, Saeko, Glüer, Claus-Christian, Goldshtein, Inbal, Goltzman, David, Gudnason, Vilmundur, Hall, Jill, Hans, Didier, Hoff, Mari, Hollick, Rosemary J, Huisman, Martijn, Iki, Masayuki, Ish-Shalom, Sophia, Jones, Graeme, Karlsson, Magnus K, Khosla, Sundeep, Kiel, Douglas P, Koh, Woon-Puay, Koromani, Fjorda, Kotowicz, Mark A, Kröger, Heikki, Kwok, Timothy, Lamy, Olivier, Langhammer, Arnulf, Larijani, Bagher, Lippuner, Kurt, Mellström, Dan, Merlijn, Thomas, Nordström, Anna, Nordström, Peter, O’Neill, Terence W, Obermayer-Pietsch, Barbara, Ohlsson, Claes, Orwoll, Eric S, Pasco, Julie A, Rivadeneira, Fernando, Schott, Anne Marie, Shiroma, Eric J, Siggeirsdottir, Kristin, Simonsick, Eleanor M, Sornay-Rendu, Elisabeth, Sund, Reijo, Swart, Karin MA, Szulc, Pawel, Tamaki, Junko, Torgerson, David J, van Schoor, Natasja M, van Staa, Tjeerd P, Vila, Joan, Wareham, Nicholas J, Wright, Nicole C, Yoshimura, Noriko, Zillikens, M Carola, Zwart, Marta, Vandenput, Liesbeth, Harvey, Nicholas C, Lorentzon, Mattias, Leslie, William D
    Publicado 2023
    “…CONCLUSION: A previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by BMD. The effect is similar in men and women. …”
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    Previous fracture and subsequent fracture risk: A meta-analysis to update FRAX
  4. 76024
    por Esquivel-Muelbert, Adriane, Phillips, Oliver L., Brienen, Roel J. W., Fauset, Sophie, Sullivan, Martin J. P., Baker, Timothy R., Chao, Kuo-Jung, Feldpausch, Ted R., Gloor, Emanuel, Higuchi, Niro, Houwing-Duistermaat, Jeanne, Lloyd, Jon, Liu, Haiyan, Malhi, Yadvinder, Marimon, Beatriz, Marimon Junior, Ben Hur, Monteagudo-Mendoza, Abel, Poorter, Lourens, Silveira, Marcos, Torre, Emilio Vilanova, Dávila, Esteban Alvarez, del Aguila Pasquel, Jhon, Almeida, Everton, Loayza, Patricia Alvarez, Andrade, Ana, Aragão, Luiz E. O. C., Araujo-Murakami, Alejandro, Arets, Eric, Arroyo, Luzmila, Aymard C., Gerardo A., Baisie, Michel, Baraloto, Christopher, Camargo, Plínio Barbosa, Barroso, Jorcely, Blanc, Lilian, Bonal, Damien, Bongers, Frans, Boot, René, Brown, Foster, Burban, Benoit, Camargo, José Luís, Castro, Wendeson, Moscoso, Victor Chama, Chave, Jerome, Comiskey, James, Valverde, Fernando Cornejo, da Costa, Antonio Lola, Cardozo, Nallaret Davila, Di Fiore, Anthony, Dourdain, Aurélie, Erwin, Terry, Llampazo, Gerardo Flores, Vieira, Ima Célia Guimarães, Herrera, Rafael, Honorio Coronado, Eurídice, Huamantupa-Chuquimaco, Isau, Jimenez-Rojas, Eliana, Killeen, Timothy, Laurance, Susan, Laurance, William, Levesley, Aurora, Lewis, Simon L., Ladvocat, Karina Liana Lisboa Melgaço, Lopez-Gonzalez, Gabriela, Lovejoy, Thomas, Meir, Patrick, Mendoza, Casimiro, Morandi, Paulo, Neill, David, Nogueira Lima, Adriano José, Vargas, Percy Nuñez, de Oliveira, Edmar Almeida, Camacho, Nadir Pallqui, Pardo, Guido, Peacock, Julie, Peña-Claros, Marielos, Peñuela-Mora, Maria Cristina, Pickavance, Georgia, Pipoly, John, Pitman, Nigel, Prieto, Adriana, Pugh, Thomas A. M., Quesada, Carlos, Ramirez-Angulo, Hirma, de Almeida Reis, Simone Matias, Rejou-Machain, Maxime, Correa, Zorayda Restrepo, Bayona, Lily Rodriguez, Rudas, Agustín, Salomão, Rafael, Serrano, Julio, Espejo, Javier Silva, Silva, Natalino, Singh, James, Stahl, Clement, Stropp, Juliana, Swamy, Varun, Talbot, Joey, ter Steege, Hans, Terborgh, John, Thomas, Raquel, Toledo, Marisol, Torres-Lezama, Armando, Gamarra, Luis Valenzuela, van der Heijden, Geertje, van der Meer, Peter, van der Hout, Peter, Martinez, Rodolfo Vasquez, Vieira, Simone Aparecida, Cayo, Jeanneth Villalobos, Vos, Vincent, Zagt, Roderick, Zuidema, Pieter, Galbraith, David
    Publicado 2020
    “…In the driest Amazonian region species-level bioclimatic distributional patterns also predict the risk of death, suggesting that these forests are experiencing climatic conditions beyond their adaptative limits. These results provide not only a holistic pan-Amazonian picture of tree death but large-scale evidence for the overarching importance of the growth–survival trade-off in driving tropical tree mortality.…”
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    Tree mode of death and mortality risk factors across Amazon forests
  5. 76025
    “…CONCLUSION: Our digital patient partner and investigator decision aids are the first to provide information technology to deliver sex/gender, POR knowledge, and decision support beyond the traditional decision aids used for health screening and/or treatment decisions. …”
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    Patient Engagement Partnerships in Clinical Trials: Development of Patient Partner and Investigator Decision Aids
  6. 76026
    “…In multivariable analysis, only GLS_AVE and GRS predicted 5-year all-cause mortality (all ps < 0.05), with the strongest association with 5-year all-cause mortality by Akaike Information Criterion analysis and significant incremental value for outcomes prediction beyond LVEF or GLS_ENDO by the likelihood ratio test. …”
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    Layer-specific strain in patients with heart failure using cardiovascular magnetic resonance: not all layers are the same
  7. 76027
    “…In addition, the module includes links to kidney research opportunities within the Can-SOLVE CKD Network and beyond. A literature review established that KidneyPRO fills an important gap in kidney-specific POR. …”
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    Program Report: KidneyPRO, a Web-based Training Module for Patient Engagement in Kidney Research
  8. 76028
    “…Experience with 2-dose schedule is extensive, with wide geographical use, while evidence beyond 10 years for the 1-dose schedule has not yet been demonstrated. …”
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    34. Impact of Universal Mass Vaccination Programs of Children Against Hepatitis a with 2-dose and 1-dose Schedules: A Systematic Literature Review
  9. 76029
    “…BACKGROUND: The effects of the COVID-19 pandemic on people living with HIV (PWH) are unknown. Beyond SARS-CoV-2 co-infection, the pandemic may have devastating consequences for HIV care delivery. …”
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    475. Describing the impact of the COVID-19 pandemic on HIV care in Latin America
  10. 76030
    “…Serum and spleen viral loads in control mice declined between days 4 and 8 but no control mice survived beyond day 8. In contrast, AT-752 treated mice survived up to day 19, eventually succumbing to model-induced CNS sequelae. …”
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    169. AT-752, an Oral Guanosine Nucleotide Prodrug, Exhibits Potent in Vitro Activity Against Flaviviruses and Prevents Disease Progression in a Dengue Mouse Model
  11. 76031
    “…Short-term fluconazole (or appropriate alternative) could follow if treatment was required beyond 14 days. Patients with a diagnosis of candidemia within 96 hrs of start of study drug who received at least 1 dose of FMGX were included in the mITT population. …”
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    147. Clinical Safety and Efficacy of Novel Antifungal, Fosmanogepix, in the Treatment of Candidemia: Results from a Phase 2 Proof of Concept Trial
  12. 76032
    por Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, Gunter, Marc J.
    Publicado 2021
    “…Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data led to improved model performance overall (continuous net reclassification improvement = 0.307 (95% CI 0.264–0.352)), and especially for young individuals below 45 years (continuous net reclassification improvement = 0.364 (95% CI 0.084–0.575)). …”
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    Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
  13. 76033
    “…In parts of the Oberpfalz, ICU capacities were almost entirely occupied by patients with corona virus infections, making reallocation to other hospitals within the district and beyond necessary. The MO managed patient pathways in an escalating manner by defining local (within the region of responsibility of a single MO), regional (within the district), and cross-regional (over district borders) reallocation lanes, as needed. …”
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    Der Ärztliche Leiter Führungsgruppe Katastrophenschutz als zentrale Entscheidungsinstanz bei der Steuerung regionaler Krankenhauskapazitäten in der Pandemie: Ein Erfahrungsbericht zur ersten Welle der COVID-19-Pandemie in einem bayerischen Regierungsbezirk
  14. 76034
    “…CONCLUSIONS AND RELEVANCE: In a large-scale international population of HIV-positive individuals, volumes of structures in the limbic system were consistently associated with current plasma markers. Our findings extend beyond the classically implicated regions of the basal ganglia and may represent a generalizable brain signature of HIV infection in the cART era.…”
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    Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV
  15. 76035
    “…Less is known, however, about the long-term mental health impact of the disease, despite many women living several years beyond their breast cancer and mental health being a major source of disability in modern societies. …”
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    Associations between breast cancer survivorship and adverse mental health outcomes: A matched population-based cohort study in the United Kingdom
  16. 76036
    “…No study detected live virus beyond day 9 of illness, despite persistently high viral loads, which were inferred from cycle threshold values. …”
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    SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis
  17. 76037
    por Sorhaindo, Annik M.
    Publicado 2021
    “…Also, the studies should be designed so that the results have meaning for a broader group of people or situations beyond where the study was done.…”
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    Glancing at the past and course-setting for the future: lessons from the last decade of research on medication abortion in high-income countries
  18. 76038
    “…Increasing the level of social interaction beyond the limits described in this work could result in future COVID-19 waves that will likely exceed the acute bed capacity in the system, and depending on the strength of the resurgence may require additional lockdown measures.…”
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    Determining the level of social distancing necessary to avoid future COVID-19 epidemic waves: a modelling study for North East London
  19. 76039
    “…In that way, SDM is a bidirectional process that goes beyond the typical informed consent. Therefore, it is known a little of the extent to which SDM influences the satisfaction with the treatment outcome along with strabismus patients. …”
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    Shared decision making and patients satisfaction with strabismus care—a pilot study
  20. 76040
    “…BACKGROUND: Asthma represents a syndrome for which our understanding of the molecular processes underlying discrete sub-diseases (i.e., endotypes), beyond atopic asthma, is limited. The public health needs to characterize etiology-associated endotype risks is becoming urgent. …”
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    Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children
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