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41por Mandal, Manab, Chowdhury, Swapan Kumar, Khan, Abdul Ashik, Baildya, Nabajyoti, Dutta, Tanmoy, Misra, Debabrata, Ghosh, Narendra Nath“…Analysis of docked conformation revealed that Baloxavir marboxil (BMX) corresponds to the highest binding energy. …”
Publicado 2021
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42por Nakagawa, Akito, Naito, Atsuhiko T., Sumida, Tomokazu, Nomura, Seitaro, Shibamoto, Masato, Higo, Tomoaki, Okada, Katsuki, Sakai, Taku, Hashimoto, Akihito, Kuramoto, Yuki, Oka, Toru, Lee, Jong-Kook, Harada, Mutsuo, Ueda, Kazutaka, Shiojima, Ichiro, Limbourg, Florian P., Adams, Ralf H., Noda, Tetsuo, Sakata, Yasushi, Akazawa, Hiroshi, Komuro, Issei“…Conditional gain-of-function mutation of β-catenin, which activates Wnt/β-catenin signaling in Bmx-positive arterial endothelial cells (Bmx/CA mice) led to progressive cardiac dysfunction and 100% mortality at 40 weeks after tamoxifen treatment. …”
Publicado 2016
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43por Zheng, Xiaobo, Song, Jinen, Yu, Chune, Zhou, Zongguang, Liu, Xiaowei, Yu, Jing, Xu, Guangchao, Yang, Jiqiao, He, Xiujing, Bai, Xin, Luo, Ya, Bao, Yu, Li, Huifang, Yang, Lie, Xu, Mingqing, Song, Nan, Su, Xiaodong, Xu, Jie, Ma, Xuelei, Shi, Hubing“…Overexpression of BMX and HCK significantly promoted colorectal epithelial cell proliferation. …”
Publicado 2022
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44por Zamponi, Martina, Mollica, Peter A., Khodour, Yara, Bjerring, Julie S., Bruno, Robert D., Sachs, Patrick C.“…To address these issues, we combined our 3D bioprinter with hydrogels containing porcine brain extracellular matrix (BMX) to test the influence of the extracellular matrix on stem cell differentiation. …”
Publicado 2023
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45“…For different groups, the data were: MTB: 30.28±6.92; BMX: 42.46±10.74; TRA: 43.22±12.00; ROA: 34.91±6.62, respectively. …”
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46por Kirkpatrick, John, Franklin, Heather, Torok, Jordan, Floyd, Scott, Anders, Carey, Fecci, Peter, Salama, April, Clarke, Jeffrey, George, Daniel, Crapo, James, Peters, Katherine“…Following a safety lead-in of 5 patients, all of whom will receive WBRT and BMX-001, 69 patients will be randomized to WBRT (3Gy/fraction x 10 fractions) with or without BMX-001 administered subcutaneously before, twice weekly during and once after WBRT (6 injections total.) …”
Publicado 2019
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47“…In these cells Stat3 is persistently phosphorylated and activated downstream of the oncogenic driver v-Src and its effector, the cytoplasmic tyrosine kinase Bmx. Canertinib exposure of Tu-2449 cells rapidly caused the inhibition of the Bmx kinase and the deactivation of Stat3. …”
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48por Osborn, Julie, Mourya, Reena, Thanekar, Unmesha, Su, Weizhe, Fei, Lin, Shivakumar, Pranavkumar, Bezerra, Jorge A.“…Conclusion: Large‐scale proteomics identified SEMA6B, SFRP3, COMMD7, BMX, and VCAM1 as biomarkers highly associated with clinical PHT in BA. …”
Publicado 2021
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49por Qiu, Yun“…In this issue of the JCI, Li et al. present data on the regulation of 3βHSD1 phosphorylation and activity by tyrosine kinase BMX. Inhibition of BMX activity by genetic or pharmacologic approaches blocked androgen biosynthesis in prostate cancer cells and inhibited tumor growth in preclinical xenograft models. …”
Publicado 2023
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50por Luginbühl, Micha, Gross, Micah, Lorenzetti, Silvio, Graf, David, Bünner, Martin J.“…Energy pumping is a way to gain kinetic energy based on an active vertical center of mass movement in rollers in sports like skateboarding, skicross, snowboard cross and BMX. While the principle of the energy transfer from the vertical movement to the horizontal movement is well understood, the question of how to achieve the optimal energy transfer is still unresolved. …”
Publicado 2023
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51por Bral, Mariusz, Pawlick, Rena, Marfil-Garza, Braulio, Dadheech, Nidheesh, Hefler, Joshua, Thiesen, Aducio, Shapiro, A. M. James“…Anakinra with etanercept, and BMX-001 did not demonstrate convincing efficacy at reducing IRI in this model, and likely need further optimization. …”
Publicado 2019
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52por Chen, Jia-Qi, Zhang, Ming-Peng, Tong, Xin-Kai, Li, Jing-Quan, Zhang, Zhou, Huang, Fei, Du, Hui-Peng, Zhou, Meng, Ai, Hua-Shui, Huang, Lu-Sheng“…Regarding the lcPERV copy numbers, PERV-A and -JX2 in Western pigs were higher than in Chinese pigs. Notably, Bama Xiang (BMX) pigs had the lowest PERV copy number (27.8±5.1), and a BMX individual had no PERV-C and the lowest PERV copy number (23), suggesting that BMX pigs were more suitable for screening and/or modification as xenograft donors. …”
Publicado 2022
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53por Ebone, Luciano Antônio, Caverzan, Andréia, Silveira, Diógenes Cecchin, Siqueira, Luciano de Oliveira, Lângaro, Nadia Canali, Chiomento, José Luís Trevizan, Chavarria, Geraldo“…Three soybean cultivars (BMX Raio, BMX Zeus, and DM 53i54) exposed to four distinct periods of accelerated aging (0, 3, 6 and 9 days) in a fully randomized experimental design. …”
Publicado 2020
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54por Burgett, Monica E., Lathia, Justin D., Roth, Patrick, Nowacki, Amy S., Galileo, Deni S., Pugacheva, Elena, Huang, Ping, Vasanji, Amit, Li, Meizhang, Byzova, Tatiana, Mikkelsen, Tom, Bao, Shideng, Rich, Jeremy N., Weller, Michael, Gladson, Candece L.“…Activation of αvβ3 and bone marrow tyrosine kinase on chromosome X (BMX) is required for migration stimulated by direct binding but not for migration stimulated by soluble factors. …”
Publicado 2016
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55por Batinic-Haberle, Ines, Tovmasyan, Artak, Huang, Zhiqing, Duan, Weina, Du, Li, Siamakpour-Reihani, Sharareh, Cao, Zhipeng, Sheng, Huaxin, Spasojevic, Ivan, Alvarez Secord, Angeles“…The lead Mn porphyrins, namely, MnTE-2-PyP(5+) (BMX-010, AEOL10113), MnTnBuOE-2-PyP(5+) (BMX-001), and MnTnHex-2-PyP(5+), were tested in numerous injuries of normal tissue and cellular and animal cancer models. …”
Publicado 2021
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56por Kancharla, A., Maoz, M., Jaber, M., Agranovich, D., Peretz, T., Grisaru-Granovsky, S., Uziely, B., Bar-Shavit, R.“…Other PH-domain signal-proteins such as Etk/Bmx and Vav(3) also associate with PAR(1) and PAR(2) through their PH domains. …”
Publicado 2015
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57por Vachot-Ganée, Laurence, Khim, Nimol, Iannello, Alexandra, Legrand, Eric, Kim, Saorin, Eam, Rotha, Khean, Chanra, Ken, Malen, Ashley, Elizabeth, Tun, Kyaw Myo, Dhorda, Mehul, Nosten, François, Souleymane, Issa Mahamat, Blein, Sophie, Pachot, Alexandre, Ariey, Frédéric, Kaiser, Karine, Ménard, Didier“…Additional multi-site studies are needed to evaluate the performances of the K13 bMx prototype assay in different epidemiological contexts such as Africa, India, or South America. …”
Publicado 2018
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58por Kang, Mi Hyun, Moon, Sung Ung, Sung, Ji Hea, Kim, Jin Won, Lee, Keun Wook, Lee, Hye Seung, Lee, Jong Seok, Kim, Jee Hyun“…CONCLUSION: These findings suggest the potential roles of HM781-36B as the treatment for EGFR-overexpressing colon cancer, singly or in combination with chemotherapeutic agents. The role of BMX expression as a marker of response to HM781-36B should be further explored.…”
Publicado 2016
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59por Valachová, Katarína, Rapta, Peter, Moura, Nuno M. M., Batinic-Haberle, Ines, Šoltés, Ladislav“…The ortho compounds MnTE-2-PyP(5+) (BMX-010, AEOL10113), MnTnBuOE-2-PyP(5+) (BMX-001) and MnTnHex-2-PyP(5+) are able to redox cycle with ascorbate whereby producing H(2)O(2) which is subsequently coupled with Cu(I) to produce the (•)OH radical essential for HA degradation. …”
Publicado 2021
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60“…RESULTS: We identified 43 differentially expressed LLPS genes that were associated with the OS of HCC patients. Five of these genes (BMX, FYN, KPNA2, PFKFB4, and SPP1) were selected to generate a prognostic risk score signature. …”
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