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301“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is handled in biosafety level 3 (BSL-3) facilities, whereas the antiviral screening of pseudotype virus is conducted in BSL-2 facilities. …”
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302por Krambrich, Janina, Bringeland, Emelie, Hesson, Jenny C., Hoffman, Tove, Lundkvist, Åke, Lindahl, Johanna F., Ling, Jiaxin“…Whatman(®) FTA(®) Classic Cards may serve as an effective and safe option for transporting hazardous samples at room temperature, particularly for RNA viruses classified as biosafety level (BSL) 2 and 3 pathogens, from sampling sites to laboratories. …”
Publicado 2022
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303por Brisse, Morgan, Fernández-Alarcón, Claudia, Huang, Qinfeng, Kirk, Natalie, Schleiss, Mark R., Liang, Yuying, Ly, Hinh“…Animal models of LF-associated SNHL have been limited in size and scope because LASV is a biosafety level 4 (BSL4) pathogen that requires its handling in a high biocontainment laboratory. …”
Publicado 2022
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304por Ortiz Valdez, Eric, Rangel-Escareño, Claudia, Matus Santos, Juan Antonio, Vázquez Romo, Rafael, Guijosa, Alberto, Villarreal-Garza, Cynthia, Arrieta, Oscar, Rodríguez-Bautista, Rubén, Caro-Sánchez, Claudia H., Ortega Gómez, Alette“…Out of the 55 included patients, the following subtypes were identified: 9 basal-like-1, 11 basal-like-2 (BSL2), 16 immunomodulatory (IM), 12 mesenchymal, 6 androgen receptor-like and 1 mesenchymal stem-like. …”
Publicado 2022
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305por Checinska Sielaff, Aleksandra, Singh, Nitin K., Allen, Jonathan E., Thissen, James, Jaing, Crystal, Venkateswaran, Kasthuri“…The draft genome sequences of 20 biosafety level 2 (BSL-2) opportunistic pathogens isolated from the environmental surfaces of the International Space Station (ISS) were presented. …”
Publicado 2016
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306“…Considering this situation, this stage is important given that it is not possible to establish a BSL-3 laboratory in poor and developing countries. …”
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307por Li, Yizhe, He, Jinyong, Zhang, Ying, Liang, Dan, Zhang, Jiaqi, Ji, Ruili, Wu, Yue, Su, Zejie, Ke, Changwen, Xu, Ning, Tang, Yong, Xu, Jianhua“…The current gold standard for neutralizing antibody detection is the conventional virus neutralization test (cVNT), which requires live pathogens and biosafety level-3 (BSL-3) laboratories, making it difficult for this method to meet the requirements of large-scale routine detection. …”
Publicado 2023
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308por Gong, Bin, Ma, Liang, Liu, Yan, Gong, Qinyu, Shelite, Thomas, Bouyer, Donald, Boor, Paul J., Lee, Yong Sun, Oberhauser, Andres“…These new approaches should prove useful in characterizing the antigenically related SFG rickettsiae R. conorii and R. rickettsii in a BSL3 environment. Future studies may lead to the development of new therapeutic strategies to inhibit the VE-cadherin-associated microvascular hyperpermeability in SFG rickettsioses.…”
Publicado 2012
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309por Gläsker, Sabine, Lulla, Aleksei, Lulla, Valeria, Couderc, Therese, Drexler, Jan Felix, Liljeström, Peter, Lecuit, Marc, Drosten, Christian, Merits, Andres, Kümmerer, Beate Mareike“…Furthermore, neutralization assays represent a useful tool to validate the efficacy of potential vaccines. As CHIKV is a BSL3 agent, neutralization assays with infectious virus need to be performed under BSL3 conditions. …”
Publicado 2013
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310por Emond, Alan, Ridd, Matthew, Sutherland, Hilary, Allsop, Lorna, Alexander, Andrew, Kyle, Jim“…DESIGN: A quota sample of adult Deaf British Sign Language (BSL) users underwent a health assessment and interview in 2012–2013. …”
Publicado 2015
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311“…We predicted that the DHH signing children would be better at imitating gestures lexicalized in their own sign language (Swedish Sign Language, SSL) than unfamiliar British Sign Language (BSL) signs, and that both groups would be better at imitating lexical signs (SSL and BSL) than non-signs. …”
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312por Konduru, Krishnamurthy, Shurtleff, Amy C., Bradfute, Steven B., Nakamura, Siham, Bavari, Sina, Kaplan, Gerardo“…The poly-ICLC formulated EBOVgp-Fc vaccine protected all the guinea pigs against EBOV lethal challenge performed under BSL-4 conditions whereas the same vaccine formulated with QS-21 or alum only induced partial protection. …”
Publicado 2016
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313“…Before the treatment, there were significant differences in history of diabetes, smoking status, blood sugar level (BSL) at admission, low-density lipoprotein cholesterol (LDL-C) level, and stent diameter between the restenosis and non-restenosis groups (all P < 0.05). …”
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314“…Significant activation was detected in the left STC only for the BSL phonological task. This task, we argue, placed greater demands on visuospatial processing than the other two tasks. …”
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315por Mouton, Jomien M., Heunis, Tiaan, Dippenaar, Anzaan, Gallant, James L., Kleynhans, Léanie, Sampson, Samantha L.“…Like other auxotrophic strains, this has subsequently been approved for use in biosafety level (BSL) 2 facilities. Auxotrophic strains have been assessed as models for drug-resistant M. tuberculosis and for studying latent TB. …”
Publicado 2019
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316por Bolken, Tove′ C., Laquerre, Sylvie, Zhang, Yuanming, Bailey, Thomas R., Pevear, Daniel C., Kickner, Shirley S., Sperzel, Lindsey E., Jones, Kevin F., Warren, Travis K., Amanda Lund, S., Kirkwood-Watts, Dana L., King, David S., Shurtleff, Amy C., Guttieri, Mary C., Deng, Yijun, Bleam, Maureen, Hruby, Dennis E.“…Many of these deadly viruses require biosafety level-4 (BSL-4) containment for all laboratory work, which limits traditional laboratory high-throughput screening (HTS) for identification of small molecule inhibitors. …”
Publicado 2006
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317por Yang, Ren, Huang, Baoying, A, Ruhan, Li, Wenhui, Wang, Wenling, Deng, Yao, Tan, Wenjie“…With the development of the COVID-19 epidemic, there is an urgent need to establish a system for determining the effectiveness and neutralizing activity of vaccine candidates in biosafety level 2 (BSL-2) facilities. Previously, researchers had developed a pseudotyped virus system for SARS-CoV and MERS-CoV, based on HIV-1 core, bearing virus spike protein. …”
Publicado 2020
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318por Becker-Sadzio, Julia, Gundel, Friederike, Kroczek, Agnes, Wekenmann, Stefanie, Rapp, Alexander, Fallgatter, Andreas J., Deppermann, Saskia“…Avoidance behavior continually decreased from the beginning until the end of therapy. Decreased BSL-23 values show major improvements regarding DSO. …”
Publicado 2020
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319por Xia, Zilei, Sacco, Michael Dominic, Ma, Chunlong, Townsend, Julia Alma, Kitamura, Naoya, Hu, Yanmei, Ba, Mandy, Szeto, Tommy, Zhang, Xiujun, Meng, Xiangzhi, Zhang, Fushun, Xiang, Yan, Marty, Michael Thomas, Chen, Yu, Wang, Jun“…Overall, the PL(pro) inhibitors identified in this study represent promising starting points for further development as SARS-CoV-2 antivirals, and FlipGFP-PL(pro) assay might be a suitable surrogate for screening PL(pro) inhibitors in the BSL-2 setting.…”
Publicado 2021
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320por Gan, Tianyu, Zhou, Dihan, Huang, Yi, Xiao, Shuqi, Ma, Ziyue, Hu, Xiaoyou, Tong, Yimin, Yan, Huimin, Zhong, Jin“…EBOV reverse genetics systems are available for studying live viruses under biosafety level 4 (BSL-4) or subviral particles under BSL-2 conditions. …”
Publicado 2021
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