Mostrando 141 - 160 Resultados de 680 Para Buscar '"BSL"', tiempo de consulta: 0.46s Limitar resultados
  1. 141
    “…One limiting factor for 3CLpro inhibitors development is that the cellular activities of such inhibitors should be evaluated in Biosafety Level 3 (BSL-3) laboratories. Here, we design DNA-coded biosensors that can be used in BSL-2 laboratories to set up cell-based assays for 3CLpro inhibitor discovery. …”
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    BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery
  2. 142
    “…We describe herein, limitations on research at biosafety level 4 (BSL-4) containment laboratories, with regard to biosecurity regulations, safety considerations, research space limitations, and physical constraints in executing experimental procedures. …”
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    The Impact of Regulations, Safety Considerations and Physical Limitations on Research Progress at Maximum Biocontainment
  3. 143
    por Nacasch, Naomi, Korzets, Ze’ev
    Publicado 2009
    “…The mean blood sugar level (BSL) following transplantation was 113.8 mg/dl. …”
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    Worsening of hyperglycemia due to atorvastatin in a renal transplant patient
  4. 144
    “…Contrary to the Vollum strain, deletion of the bslA gene fully attenuated the ∆pXO2 strain. Though the Vollum∆pXO2 cannot serve as a model for B. anthracis pathogenicity in rabbits, deletion of the bslA gene prevents central nervous system (CNS) infections, possibly leading to the generation of a safer vaccine.…”
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    Infection with a Nonencapsulated Bacillus anthracis Strain in Rabbits—The Role of Bacterial Adhesion and the Potential for a Safe Live Attenuated Vaccine
  5. 145
    “…The reported depressive symptoms decreased from 21.11% (BSL) to 1.11% (SVR) (p < 0.00001), while the anxious ones dropped from 43.34% (BSL) to 4.44% (SVR) (p < 0.00001), without a clear evolutionary pattern. …”
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    Depressive and Anxious Symptoms in Hepatitis C Virus Infected Patients Receiving DAA-Based Therapy
  6. 146
    “…In Germany, the live attenuated SARS-CoV-2 mutant sCPD9 was recently classified as a BSL-2 pathogen based on its genetic stability and strong attenuation in preclinical animal models. …”
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    Synthetically recoded virus sCPD9 – A tool to accelerate SARS-CoV-2 research under biosafety level 2 conditions
  7. 147
    “…At 30 days and 12 months, those with BSL ≥ 11.1 mmol/L had more MACE and death compared to those with BSL < 6.0 mmol/L or 6.0–11.1 mmol/L (HR-ratio 4.78 and 6.6; p < 0.001). …”
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    Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61
  8. 148
    “…BSL10 showed significantly higher secretion of glucosidases (69.4±0.79 μM(-1)min(-1)mL) and phosphatases (3.46±0.31μM(-1)min(-1)mL) compared to other strains. …”
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    Endophytic Fungi from Frankincense Tree Improves Host Growth and Produces Extracellular Enzymes and Indole Acetic Acid
  9. 149
    “…As a screening platform, we used reverse genetics-based life cycle modelling systems that recapitulate these processes without the need for a BSL4 laboratory. RESULTS: Among others, we identified the de novo pyrimidine synthesis pathway as an essential host pathway for EBOV genome replication and transcription, and confirmed this using infectious EBOV under BSL4 conditions. …”
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    A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
  10. 150
    “…SARS-CoV-2 is highly pathogenic in humans and is classified as a biosafety level (BSL)-3 pathogen, which makes manipulating it relatively difficult due to its infectious nature. …”
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    Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein
  11. 151
    “…Unlike studies involving infectious SARS-CoV-2 virus that must be performed in a biosafety level 3 (BSL3) facility, the replicon is noninfectious and thus can be safely used in BSL2 laboratories. …”
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    Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies
  12. 152
    “…OBJECTIVE: We sought to examine the impact and challenges of tuberculosis diagnostic capacity development for the detection of drug-resistant tuberculosis and bio-surveillance using a modular biosafety level 3 (BSL-3) laboratory in Nigeria. METHOD: In 2010, the United States President’s Emergency Plan for AIDS Relief (PEPFAR) programme, through the Institute of Human Virology at the University of Maryland in Baltimore, Maryland, United States, deployed a modular, BSL-3 laboratory to support the national tuberculosis programme in drug-resistant tuberculosis detection and bio-surveillance for effective tuberculosis prevention and control. …”
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    Diagnostic system strengthening for drug resistant tuberculosis in Nigeria: impact and challenges
  13. 153
    “…It is further shown that the level of incompleteness of the BSL and the defined dissimilarity threshold are decisive for the detection of unknown material classes and the degree of spectral intra-class variability. …”
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    Detecting Unknown Artificial Urban Surface Materials Based on Spectral Dissimilarity Analysis
  14. 154
    “…By contrast, the level of ligase I activity in BSL‐2KA, another BS LCL derived from a Japanese patient, was equivalent to those in normal LCLs, although GM3403 and BSL‐2KA shared the feature of exceedingly high frequency of spontaneous sister‐chromatid exchange. …”
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    Two Types of DNA Ligase I Activity in Lymphoblastoid Cells from Patients with Bloom's Syndrome
  15. 155
    “…Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs. …”
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    Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors
  16. 156
    “…We collected fMRI data from deaf and hearing proficient users (N ​= ​52) of British Sign Language (BSL), who learnt BSL either early (native) or late (after the age of 15 years) whilst they watched BSL sentences or strings of meaningless nonsense signs. …”
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    The impact of early language exposure on the neural system supporting language in deaf and hearing adults
  17. 157
    “…There were five high biosafety level (BSL) laboratories (one BSL3 laboratory each in Cameroon, the Central African Republic, Democratic Republic of Congo and the Republic of Congo, and one BSL4 laboratory in Gabon) and three ISO 17025-accredited laboratories in the ECCAS sub-region. …”
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    Microbiology laboratories involved in disease and antimicrobial resistance surveillance: Strengths and challenges of the central African states
  18. 158
    “…We noted discrete contributions to biofilm morphology, mechanical properties, and survival from major biofilm components such as EPS, TasA and BslA. For example, EPS plays an important role in maintaining the stability of the mechanical properties and the antibiotic resistance of biofilms, whereas BslA has a significant impact on the resolution that can be obtained for printing applications. …”
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    Probing the growth and mechanical properties of Bacillus subtilis biofilms through genetic mutation strategies
  19. 159
    “…Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. …”
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    Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results
  20. 160
    “…Here, due to the different reflectance (R) between the SMF and organic liquid chemicals, the reflected power level of the backscattering light (BSL) measured by the OTDR would be different. Therefore, we can measure the RI of chemical under test via the measured BSL level. …”
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    Measurement of Organic Chemical Refractive Indexes Using an Optical Time-Domain Reflectometer
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