“…Barbara McClintock was the first to suggest that transposons are a source of genome instability and that genotoxic stress assisted in their mobilization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock’s famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Transposable elements (TEs) were discovered by Barbara McClintock in maize and have since been found to be ubiquitous in all living organisms. …”
Enlace del recurso
Enlace del recurso

“…Heritable, but reversible, changes in transposable element activity were first observed in maize by Barbara McClintock in the 1950s. More recently, transposon silencing has been associated with DNA methylation, histone H3 lysine-9 methylation (H3mK9), and RNA interference (RNAi). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These data provide strong support for the idea, first proposed by Barbara McClintock, that TEs provide a system to modify the genome in response to stress.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Since Barbara McClintock’s groundbreaking discovery of mobile DNA sequences some 70 years ago, transposable elements have come to be recognized as important mutagenic agents impacting genome composition, genome evolution, and human health. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Since the discovery of ‘Dissociation (Dc) locus’ by Barbara McClintock in maize (1), mounting evidence in the era of genomics indicates that a significant fraction of most eukaryotic genomes is composed of TE sequences, involving in various aspects of biological processes such as development, physiology, diseases and evolution. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is well known that Gregor Mendel discovered the laws of Genetics in peas and that maize was used for the discovery of transposons by Barbara McClintock. Plant models are still useful for the understanding of general key biological concepts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The propagation of L1 in the human genome requires disruption and repair of DNA at the site of integration. As Barbara McClintock first hypothesized, genotoxic stress may contribute to the mobilization of transposable elements, and conversely, element mobility may contribute to genotoxic stress. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In contrast, it is considered by the encyclopedia of DNA elements discovery as biochemically functional and regulatory, and the transposable elements were considered earlier by Barbara McClintock as “controlling elements” of genes. Remarkably, it is found that repeated elements can statistically identify significantly, the five species of subterranean mole rats of Spalax ehrenbergi superspecies adapted to increasingly arid climatic trend southward in Israel. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Other data have also suggested a different mechanism that revitalizes another classic debate about the response of genome to physiological and environmental stress put forward by Barbara McClintock. That data demonstrated that Hsp90 is involved in repression of transposon activity by playing a significant role in piwi-interacting RNA (piRNAs)-dependent RNA interference (RNAi) silencing. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A summary definition of some 70 descriptions of intelligence provides a definition for all other organisms including plants that stresses fitness. Barbara McClintock, a plant biologist, posed the notion of the ‘thoughtful cell’ in her Nobel prize address. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This paper gives formal foundations and evidence from gene science in the post Barbara McClintock era that the Gödel Sentence, far from being an esoteric construction in mathematical logic, is ubiquitous in genomic intelligence that evolved with multi-cellular life. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Transposable elements, once described by Barbara McClintock as controlling genetic units, not only occupy the largest part of our genome but are also a prominent moving force of genomic plasticity and innovation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Barbara McClintock first hypothesized that interspecific hybridization could provide a “genomic shock” that leads to the mobilization of transposable elements (TEs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…They were first discovered by Barbara McClintock while working on maize, and they make up a large fraction of the genome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Her contribution was acknowledged posthumously in Watson’s memoir in 1968. Barbara McClintock was a 20th century American cytogeneticist who remains up to date the only woman receiving an unshared Nobel prize in Physiology or Medicine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The history of rDNA research started almost 90 years ago when the geneticist, Barbara McClintock observed that in interphase nuclei of maize the nucleolus was formed in association with a specific region normally located near the end of a chromosome, which she called the nucleolar organizer region (NOR). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso