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841por Hammond-Martel, Ian, Pak, Helen, Yu, Helen, Rouget, Raphael, Horwitz, Andrew A., Parvin, Jeffrey D., Drobetsky, Elliot A., Affar, El Bachir“…Significantly, we found that inhibition of BRCA1/BARD1 downregulation is accompanied by the unscheduled recruitment of both proteins to chromatin along with Rad51. …”
Publicado 2010
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842por Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin“…We show that BARD exhibits the highest potency toward Nrf2 and the largest in vitro therapeutic index among compounds that have been investigated clinically (namely BARD, sulforaphane and dimethylfumarate). …”
Publicado 2014
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843por Peng, Yihan, Liao, Qingchao, Tan, Wei, Peng, Changmin, Hu, Zhaohua, Chen, Yali, Li, Zhuqing, Li, Jing, Zhen, Bei, Zhu, Wenge, Li, Xiangpan, Yao, Yi, Song, Qibin, Liu, Chengsheng, Qi, Xiangdong, He, Fuchu, Pei, Huadong“…Subsequently, USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1γ interaction, resulting in BRCA1/BARD1 retention at DSBs. …”
Publicado 2019
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844por Padeken, Jan, Zeller, Peter, Towbin, Benjamin, Katic, Iskra, Kalck, Veronique, Methot, Stephen P., Gasser, Susan M.“…Unlike set-25 mutants, met-2-null worms accumulated satellite repeat transcripts, which form RNA:DNA hybrids on repetitive sequences, additively with the loss of BRCA1 or BARD1. BRCA1/BARD1-mediated H2A ubiquitination and MET-2 deposited H3K9me2 on satellite repeats are partially interdependent, suggesting both that the loss of silencing generates BRCA-recruiting DNA damage and that BRCA1 recruitment by damage helps silence repeats. …”
Publicado 2019
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845por Saran, Mohit, Sharma, Jugal Kishore, Ranjan, Aastha, Deka, Saurav, Sabharwal, Mudit, Palukari, Srivani, Chandolia, Betina“…NAFLD fibrosis score, BARD score, and aspartate aminotransferase to platelet ratio index (APRI) score. …”
Publicado 2022
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846“…Subgroup analyses involving non-obese participants, male participants, and participants without metabolic syndrome showed similar results. The BARD score and the proportion of significant fibrosis by BARD score did not differ according to vitamin D status. …”
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848“…These couplings are necessary to calculate pi+J/psi --> D^(*)+barD^(*) cross sections, an important background to the J/psi suppression signal in the quark-gluon plasma. …”
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849
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850“…The most conserved region of BRCA1 and BARD1 homologs in plants is a PHD domain which is absent in mammals and which, in AtBARD1, might be involved in the transcriptional regulation of plant development. …”
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851“…Five LFSs, namely, non‐alcoholic fatty liver disease fibrosis score (NFS), fibrosis‐4 score (FIB‐4), BARD, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, and Health Utilities Index (HUI) scores were adopted. …”
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852“…This case describes a 57-year-old morbidly obese woman with complications of a permanent Bard inferior vena cava (IVC) filter (BD Bard, Covington, Ga) placed in 2005. …”
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853“…Background Artificial intelligence (AI)-based conversational models, such as Chat Generative Pre-trained Transformer (ChatGPT), Microsoft Bing, and Google Bard, have emerged as valuable sources of health information for lay individuals. …”
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854por Fujiki, Tamami, Ando, Fumiaki, Murakami, Kana, Isobe, Kiyoshi, Mori, Takayasu, Susa, Koichiro, Nomura, Naohiro, Sohara, Eisei, Rai, Tatemitsu, Uchida, Shinichi“…As a result, tolvaptan and BARD could successfully generate synergistic activating effects on Nrf2/HO-1 antioxidant pathway, suggesting that this combination therapy can contribute to the treatment of CKD.…”
Publicado 2019
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855por Borges-Canha, Marta, Neves, João Sérgio, Mendonça, Fernando, Silva, Maria Manuel, Costa, Cláudia, Cabral, Pedro M., Guerreiro, Vanessa, Lourenço, Rita, Meira, Patrícia, Salazar, Daniela, Ferreira, Maria João, Pedro, Jorge, Leite, Ana, Von-Hafe, Madalena, Vale, Catarina, Viana, Sara, Sande, Ana, Belo, Sandra, Lau, Eva, Freitas, Paula, Carvalho, Davide“…Fatty Liver Index (FLI) and BARD scores were used as predictors of hepatic steatosis and fibrosis, respectively. …”
Publicado 2020
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856“…BRCA1 forms a heterodimer with BRCA1‐associated RING domain protein 1 (BARD1) and functions in multiple cellular processes, including DNA repair and centrosome regulation. …”
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857por Chen, Xiaoning, Goh, George Boon-Bee, Huang, Jiaofeng, Wu, Yinlian, Wang, Mingfang, Kumar, Rahul, Lin, Su, Zhu, Yueyong“…The AUROC of NFS was followed by APRI, FIB-4, and BARD in the NHANES cohort (0.616, 0.601, and 0.589, respectively). …”
Publicado 2022
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858“…Patients who underwent a rRS VHR were included in this study and separated into two groups depending on the mesh used: Synecor(TM) Preperitoneal Biomaterial (Synecor(TM) Pre) and Bard™ Soft. Through propensity score and inverse-probability-treatment-weighting, the ATT was estimated for two scenarios; the first with the treated target having used the Synecor(TM) Pre, the second having used the Bard™ Soft mesh. …”
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859por Aleskandarany, Mohammed, Caracappa, Daniela, Nolan, Christopher C., Macmillan, R. Douglas, Ellis, Ian O., Rakha, Emad A., Green, Andrew R.“…The following DNA damage response (DDR) markers are used; BRCA1, BRCA2, RAD51, Ku70/Ku80, BARD, PARP1 (cleaved), PARP1 (non-cleaved), and P53 in addition to basal cytokeratins, ER, PR, and HER2. …”
Publicado 2015
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860por Fukuda, Takayo, Wu, Wenwen, Okada, Maiko, Maeda, Ichiro, Kojima, Yasuyuki, Hayami, Ryosuke, Miyoshi, Yasuo, Tsugawa, Ko-ichiro, Ohta, Tomohiko“…Reflecting their effects on histone modifications, the HDAC inhibitors inhibit ionizing radiation-induced foci (IRIF) formation of BRCA1 and BARD1 as well as 53BP1 and RIF1, whereas UNC0638 suppresses IRIF formation of BRCA1 and BARD1 but not 53BP1 and RIF1. …”
Publicado 2015
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