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  1. 1141
    “…Twelve healthy experimental, intact, male beagle dogs without evidence of prostatic pathology were recruited. …”
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    MRI-guided, transrectal, intraprostatic steam application as potential focal therapeutic modality for prostatic diseases in a large animal translational model: A feasibility follow-up study
  2. 1142
    por Ando, Kentaro, Wada, Takeshi, Cao, Xin
    Publicado 2020
    “…We intravenously administered lapatinib to chronic atrioventricular block beagle dogs to assess its proarrhythmic potential. …”
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    Precise safety pharmacology studies of lapatinib for onco-cardiology assessed using in vivo canine models
  3. 1143
    “…ANIMALS: Eleven dogs with CIE and 6 healthy beagle controls (CO). METHODS: Retrospective case‐control study. …”
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    Ki‐67/CD3 ratio in the diagnosis of chronic inflammatory enteropathy in dogs
  4. 1144
    “…METHODS: We conducted chronic AF animal models with 18 beagle dogs and divided them into SR (pacemaker implanted without pacing), AF (pacemaker implanted with sustained pacing at a frequency of 400 beats/min for 6 weeks), and metformin+AF group (daily oral administration of metformin was initiated 1 week before surgery and continued throughout the study period). …”
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    Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation
  5. 1145
    “…A preclinical study using beagle models is frequently performed prior to clinical application in dentistry. …”
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    Comparison of experimental peri-implantitis models after application of ex vivo BMP2 gene therapy using periodontal ligament stem cells
  6. 1146
    “…Safety, immunogenicity and efficacy of the developed vaccine were evaluated in vivo. Five 10-week-old beagle pups were administered (three weeks apart) two vaccine doses, whereas two animals served as unvaccinated controls. …”
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    Immunogenicity and protective efficacy in dogs of an MF59™-adjuvanted vaccine against recombinant canine/porcine coronavirus
  7. 1147
    “…Normal mammary gland tissue samples were obtained from five female beagle dogs. RT-PCR and sequencing of the amplified PCR products demonstrated the presence of TRPM7 mRNA in normal mammary glands, and the presence of TRPM7 protein was confirmed by Western blotting. …”
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    The Presence and Distribution of TRPM7 in the Canine Mammary Glands
  8. 1148
    “…We demonstrate the efficacy of toolkit for evaluation of imputations made with both fastPHASE and BEAGLE software for HapMap and 1000 Genomes data. …”
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    imputeqc: an R package for assessing imputation quality of genotypes and optimizing imputation parameters
  9. 1149
    “…ANIMALS: Six healthy adult colony beagle dogs. METHODS: Gastrointestinal permeability and inflammation were assessed by serum lipopolysaccharide (LPS) concentration, plasma iohexol concentration, fecal DI, and fecal calprotectin concentration in a prospective, 3‐period design. …”
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    The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs
  10. 1150
    “…We use the genotype likelihood input mode in Beagle and filter for confident genotypes as the input to impute missing genotypes. …”
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    Evaluating genotype imputation pipeline for ultra-low coverage ancient genomes
  11. 1151
    “…To this end, we extrapolated eight previously established rabbit models for several drugs to six additional mammalian species (human, beagle, rat, monkey, mouse, and minipig). We used established PBTK models for these species to account for the species-specific physiology. …”
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    A workflow to build PBTK models for novel species
  12. 1152
    por Sebbag, Lionel, Mochel, Jonathan P.
    Publicado 2020
    “…This pilot study aimed to determine the plasma pharmacokinetics of prednisone and its active metabolite prednisolone following oral prednisone administration in dogs—using dosing regimens that cover anti-inflammatory to immuno-suppressive biological effects. Six healthy Beagle dogs were given 0.5, 1, 2, and 4 mg/kg prednisone orally once daily for 5 days, each successive course separated by a washout period of 9 days. …”
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    Pharmacokinetics of Oral Prednisone at Various Doses in Dogs: Preliminary Findings Using a Naïve Pooled-Data Approach
  13. 1153
    “…To shed some light on these shortcomings the specific IgG subclass response was followed in 20 Beagle dogs experimentally infected with L. infantum using monoclonal antibodies (MAb) specific for canine IgG(1), IgG(2), IgG(3) and IgG(4), along with ELISA and flow cytometry. …”
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    Infection of dogs by Leishmania infantum elicits a general response of IgG subclasses
  14. 1154
    “…ANIMALS: Ten laboratory‐bred Beagle dogs. METHODS: Prospective, experimental study. …”
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    Three‐dimensional bladder ultrasound for estimation of urine volume in dogs compared with traditional 2‐dimensional ultrasound methods
  15. 1155
    “…The highest heart rate has been reported in Doberman and the lowest in Beagle. The heart rate was lowest at the age group of 6 months-2.5 years and highest around 10.5-12.5 years irrespective of breed and sex. …”
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    A study on the electrocardiography in dogs: Reference values and their comparison among breeds, sex, and age groups
  16. 1156
    “…To further understand the mechanism of virus infection and host-virus interactions, we characterized the complete phosphoproteome of dogs infected with H3N2 CIV. Nine-week-old Beagle dogs were inoculated intranasally with 10(6) EID(50) of A/canine/Guangdong/04/2014 (H3N2) virus. …”
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    Phosphoproteomics to Characterize Host Response During H3N2 Canine Influenza Virus Infection of Dog Lung
  17. 1157
    “…Forty maxillary fourth premolar teeth with surrounding alveolar bone were harvested from beagle cadavers. Inclusion criteria included maxillary fourth premolars with no evidence of disease and similar distal root canal volumes on radiographic evaluation. …”
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    Effect of Alternative Palatal Root Access Technique on Fracture Resistance of Root Canal Treated Maxillary Fourth Premolar Teeth in Dogs
  18. 1158
    “…To investigate blood glucose (BG) lowering potency, Gla‐300 and Gla‐100 were compared after intravenous (IV, for 4 h) and SC (for 24 h) injection in healthy Beagle dogs. MATERIALS AND METHODS: The dose of 0.15 U/kg Gla‐300 and Gla‐100 was injected IV in 12 dogs. …”
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    Equipotency of insulin glargine 300 and 100 U/mL with intravenous dosing but differential bioavailability with subcutaneous dosing in dogs
  19. 1159
    “…OBJECTIVE: The purpose is to observe the effects and neural mechanism of cutting upper thoracic sympathetic trunk (TST) on the ventricular rate (VR) during persistent atrial fibrillation (AF). METHODS: Twelve beagle dogs were halving to the control group and experimental group, 6 dogs for each group. …”
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    Effects and Mechanisms of Cutting Upper Thoracic Sympathetic Trunk on Ventricular Rate in Ambulatory Canines with Persistent Atrial Fibrillation
  20. 1160
    “…Next, we created an experimental model of periodontitis in furcation of premolars of beagle dogs. Then, S-PRG nanofiller coating was applied onto exposed tooth root surfaces. …”
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    Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers
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