Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

por Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J., Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo–Benito, Francisco Javier, Gnädig, Nina F., Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J., Ng, Caroline L., Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W., Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N., Weller, Thomas, Fischli, Walter, Fidock, David A., Clozel, Martine, Wittlin, Sergio
Publicado 2016

Factors related to the development of health-promoting community activities in Spanish primary healthcare: two case–control studies

por March, Sebastià, Ripoll, Joana, Jordan Martin, Matilde, Zabaleta-del-Olmo, Edurne, Benedé Azagra, Carmen Belén, Elizalde Soto, Lázaro, Vidal, Mª Clara, Bauzà Amengual, María de Lluc, Planas Juan, Trinidad, Pérez Mariano, Damiana Maria, Llull Sarralde, Micaela, Ruiz-Giménez, Juan Luís, Bajo Viñas, Rosa, Solano Villarubia, Carmen, Rodriguez Bajo, Maria, Cordoba Victoria, Manuela, Badia Capdevila, Marta, Serrano Ferrandez, Elena, Bosom Diumenjo, Maria, Montaner-Gomis, Isabel, Bolibar-Ribas, Buenaventura, Antoñanzas Lombarte, Angel, Bregel Cotaina, Samantha, Calvo Tocado, Ana, Olivan Blázquez, Barbara, Magallon Botaya, Rosa, Marín Palacios, Pilar, Echauri Ozcoidi, Margarita, Perez - arauta, María Jose, Llobera, Joan, Ramos, Maria
Publicado 2017

Limitation of life support techniques at admission to the intensive care unit: a multicenter prospective cohort study

por Rubio, Olga, Arnau, Anna, Cano, Sílvia, Subirà, Carles, Balerdi, Begoña, Perea, María Eugenía, Fernández-Vivas, Miguel, Barber, María, Llamas, Noemí, Altaba, Susana, Prieto, Ana, Gómez, Vicente, Martin, Mar, Paz, Marta, Quesada, Belen, Español, Valentí, Montejo, Juan Carlos, Gomez, José Manuel, Miro, Gloria, Xirgú, Judith, Ortega, Ana, Rascado, Pedro, Sánchez, Juan María, Marcos, Alfredo, Tizon, Ana, Monedero, Pablo, Zabala, Elisabeth, Murcia, Cristina, Torrejon, Ines, Planas, Kenneth, Añon, José Manuel, Hernandez, Gonzalo, Fernandez, María-del-Mar, Guía, Consuelo, Arauzo, Vanesa, Perez, José Miguel, Catalan, Rosa, Gonzalez, Javier, Poyo, Rosa, Tomas, Roser, Saralegui, Iñaki, Mancebo, Jordi, Sprung, Charles, Fernández, Rafael
Publicado 2018

The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders

por Alcolea, Daniel, Clarimón, Jordi, Carmona-Iragui, María, Illán-Gala, Ignacio, Morenas-Rodríguez, Estrella, Barroeta, Isabel, Ribosa-Nogué, Roser, Sala, Isabel, Sánchez-Saudinós, M. Belén, Videla, Laura, Subirana, Andrea, Benejam, Bessy, Valldeneu, Sílvia, Fernández, Susana, Estellés, Teresa, Altuna, Miren, Santos-Santos, Miguel, García-Losada, Lídia, Bejanin, Alexandre, Pegueroles, Jordi, Montal, Víctor, Vilaplana, Eduard, Belbin, Olivia, Dols-Icardo, Oriol, Sirisi, Sònia, Querol-Vilaseca, Marta, Cervera-Carles, Laura, Muñoz, Laia, Núñez, Raúl, Torres, Soraya, Camacho, M. Valle, Carrió, Ignasi, Giménez, Sandra, Delaby, Constance, Rojas-Garcia, Ricard, Turon-Sans, Janina, Pagonabarraga, Javier, Jiménez, Amanda, Blesa, Rafael, Fortea, Juan, Lleó, Alberto
Publicado 2019

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

por Reinhardt, Annekathrin, Stichel, Damian, Schrimpf, Daniel, Koelsche, Christian, Wefers, Annika K., Ebrahimi, Azadeh, Sievers, Philipp, Huang, Kristin, Casalini, M. Belén, Fernández-Klett, Francisco, Suwala, Abigail, Weller, Michael, Gramatzki, Dorothee, Felsberg, Joerg, Reifenberger, Guido, Becker, Albert, Hans, Volkmar H., Prinz, Marco, Staszewski, Ori, Acker, Till, Dohmen, Hildegard, Hartmann, Christian, Paulus, Werner, Heß, Katharina, Brokinkel, Benjamin, Schittenhelm, Jens, Buslei, Rolf, Deckert, Martina, Mawrin, Christian, Hewer, Ekkehard, Pohl, Ute, Jaunmuktane, Zane, Brandner, Sebastian, Unterberg, Andreas, Hänggi, Daniel, Platten, Michael, Pfister, Stefan M., Wick, Wolfgang, Herold-Mende, Christel, Korshunov, Andrey, Reuss, David E., Sahm, Felix, Jones, David T. W., Capper, David, von Deimling, Andreas
Publicado 2019

Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain

por Fernández Colomer, Belén, Sánchez-Luna, Manuel, de Alba Romero, Concepción, Alarcón, Ana, Baña Souto, Ana, Camba Longueira, Fátima, Cernada, María, Galve Pradell, Zenaida, González López, María, López Herrera, M. Cruz, Ribes Bautista, Carmen, Sánchez García, Laura, Zamora Flores, Elena, Pellicer, Adelina, Alonso Díaz, Clara, Herraiz Perea, Cristina, Romero Ramírez, Dolores Sabina, de las Cuevas Terán, Isabel, Pescador Chamorro, Isabel, Fernández Trisac, José Luis, Arruza Gómez, Luis, Cardo Fernández, Luis Miguel, García García, Mª Jesús, Nicolás López, Marta, Hortelano López, Miryam, Riaza Gómez, Mónica, Hernández González, Natalio, González Sánchez, Raquel, Zambudio Sert, Sílvia, Larrosa Capacés, Susana, Matías del Pozo, Vanesa
Publicado 2020

Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure

por Trejo-Velasco, Blanca, Estevez-Loureiro, Rodrigo, Carrasco-Chinchilla, Fernando, Fernández-Vázquez, Felipe, Arzamendi, Dabit, Pan, Manuel, Pascual, Isaac, Nombela-Franco, Luis, Amat-Santos, Ignacio J., Freixa, Xavier, Hernández-Antolín, Rosa Ana, Trillo-Nouche, Ramiro, Andraka Ikazuriaga, Leire, López-Mínguez, José R., Sanmiguel Cervera, Dario, Sanchis, Juan, Diez-Gil, José Luis, Ruiz-Quevedo, Valeriano, Urbano-Carrillo, Cristóbal, Becerra-Muñoz, Víctor Manuel, Benito-González, Tomás, Li, Chi Hion, Mesa, Dolores, Avanzas, Pablo, Armijo, Germán, Serrador-Frutos, Ana María, Sanchis, Laura, Lobán, Covadonga Fernández-Golfín, Cid-Álvarez, Belén, Hernández-García, José María, Garrote-Coloma, Carmen, Fernández-Peregrina, Estefanía, Romero, Miguel, León Arguero, Víctor, Cruz-González, Ignacio
Publicado 2021

Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador

por Gutierrez, Bernardo, Márquez, Sully, Prado-Vivar, Belén, Becerra-Wong, Mónica, Guadalupe, Juan José, da Silva Candido, Darlan, Fernandez-Cadena, Juan Carlos, Morey-Leon, Gabriel, Armas-Gonzalez, Rubén, Andrade-Molina, Derly Madeleiny, Bruno, Alfredo, de Mora, Domenica, Olmedo, Maritza, Portugal, Denisse, Gonzalez, Manuel, Orlando, Alberto, Drexler, Jan Felix, Moreira-Soto, Andres, Sander, Anna-Lena, Brünink, Sebastian, Kühne, Arne, Patiño, Leandro, Carrazco-Montalvo, Andrés, Mestanza, Orson, Zurita, Jeannete, Sevillano, Gabriela, du Plessis, Louis, McCrone, John T., Coloma, Josefina, Trueba, Gabriel, Barragán, Verónica, Rojas-Silva, Patricio, Grunauer, Michelle, Kraemer, Moritz U.G., Faria, Nuno R., Escalera-Zamudio, Marina, Pybus, Oliver G., Cárdenas, Paúl
Publicado 2021

Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador

por Gutierrez, Bernardo, Márquez, Sully, Prado-Vivar, Belén, Becerra-Wong, Mónica, Guadalupe, Juan José, Candido, Darlan Da Silva, Fernandez-Cadena, Juan Carlos, Morey-Leon, Gabriel, Armas-Gonzalez, Rubén, Andrade-Molina, Derly Madeleiny, Bruno, Alfredo, De Mora, Domenica, Olmedo, Maritza, Portugal, Denisse, Gonzalez, Manuel, Orlando, Alberto, Drexler, Jan Felix, Moreira-Soto, Andres, Sander, Anna-Lena, Brünink, Sebastian, Kühne, Arne, Patiño, Leandro, Carrazco-Montalvo, Andrés, Mestanza, Orson, Zurita, Jeannete, Sevillano, Gabriela, Du Plessis, Louis, McCrone, John T, Coloma, Josefina, Trueba, Gabriel, Barragán, Verónica, Rojas-Silva, Patricio, Grunauer, Michelle, Kraemer, Moritz U G, Faria, Nuno R, Escalera-Zamudio, Marina, Pybus, Oliver G, Cárdenas, Paúl
Publicado 2021

Multicentre, randomised, open-label, phase IV–III study to evaluate the efficacy of cloxacillin plus fosfomycin versus cloxacillin alone in adult patients with methicillin-suscepti...

por Grillo, Sara, Cuervo, Guillermo, Carratala, Jordi, San-Juan, Rafael, Aguado, Jose M, Morata, Laura, Gomez-Zorrilla, Silvia, López-Contreras, Joaquín, Gasch, Oriol, Gomila-Grange, Aina, Iftimie, Simona, Garcia-Pardo, Graciano, Calbo, Esther, Boix-Palop, Lucía, Oriol, Isabel, Jover-Sáenz, Alfredo, López-Cortés, Luis Eduardo, Euba, Gorane, Aguirregabiria, Malen, Garcia-Pais, Maria Jose, Gioia, Francesca, Paño, Jose Ramón, Pedro-Botet, Maria Luisa, Benítez, Rosa Maria, Pérez-Rodríguez, Maria Teresa, Meije, Yolanda, Loeches-Yagüe, Maria Belén, Horna, Gertrudis, Berbel, Damaris, Domínguez, Maria Ángeles, Padullés, Ariadna, Cobo, Sara, Hereu, Pilar, Videla, Sebastian, Tebe, Cristian, Pallarés, Natàlia, Miro, Josep M, Pujol, Miquel
Publicado 2021

Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov...

por García de Guadiana-Romualdo, Luis, Rodríguez Rojas, Carlos, Morell-García, Daniel, Andaluz-Ojeda, David, Rodríguez Mulero, María Dolores, Rodríguez-Borja, Enrique, Ballesteros-Vizoso, Antonieta, Calvo, María Dolores, Albert-Botella, Lourdes, Pozo Giráldez, Adela, Llompart-Alabern, Isabel, Bolado Jiménez, Cristina, Hernández Olivo, Marta, Fernández Presa, Lucía, Ortega-Pérez, Juan, Fora Romero, María José, Campos-Rodríguez, Valerio, Ballester Férriz, Andrea, Guiu-Martí, Alexandra M., Pinilla Arribas, Leyre, Galindo Martínez, María, Puerto-Lara, Edwin R., López Tarazaga, Ana Belen, Ros Braquehais, María Salomé, Nogales Martín, Leonor, Juez Santamaría, Celia, Trapiello Fernández, Wysalli, Espinilla Fernández, Virginia, Havelka, Aleksandra, Albaladejo-Otón, María Dolores
Publicado 2021

KCNV2-Associated Retinopathy: Detailed Retinal Phenotype and Structural Endpoints—KCNV2 Study Group Report 2

por Georgiou, Michalis, Fujinami, Kaoru, Vincent, Ajoy, Nasser, Fadi, Khateb, Samer, Vargas, Mauricio E., Thiadens, Alberta A.H.J., de Carvalho, Emanuel R., Nguyen, Xuan-Thanh-An, De Guimarães, Thales Antônio Cabral, Robson, Anthony G., Mahroo, Omar A., Pontikos, Nikolas, Arno, Gavin, Fujinami-Yokokawa, Yu, Leo, Shaun Michael, Liu, Xiao, Tsunoda, Kazushige, Hayashi, Takaaki, Jimenez-Rolando, Belen, Martin-Merida, Maria Inmaculada, Avila-Fernandez, Almudena, Carreño, Ester, Garcia-Sandoval, Blanca, Ayuso, Carmen, Sharon, Dror, Kohl, Susanne, Huckfeldt, Rachel M., Boon, Camiel J.F., Banin, Eyal, Pennesi, Mark E., Wissinger, Bernd, Webster, Andrew R., Héon, Elise, Khan, Arif O., Zrenner, Eberhart, Michaelides, Michel
Publicado 2021

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

por Gendron, Tania F., Heckman, Michael G., White, Launia J., Veire, Austin M., Pedraza, Otto, Burch, Alexander R., Bozoki, Andrea C., Dickerson, Bradford C., Domoto-Reilly, Kimiko, Foroud, Tatiana, Forsberg, Leah K., Galasko, Douglas R., Ghoshal, Nupur, Graff-Radford, Neill R., Grossman, Murray, Heuer, Hilary W., Huey, Edward D., Hsiung, Ging-Yuek R., Irwin, David J., Kaufer, Daniel I., Leger, Gabriel C., Litvan, Irene, Masdeu, Joseph C., Mendez, Mario F., Onyike, Chiadi U., Pascual, Belen, Ritter, Aaron, Roberson, Erik D., Rojas, Julio C., Tartaglia, Maria Carmela, Wszolek, Zbigniew K., Rosen, Howard, Boeve, Bradley F., Boxer, Adam L., Petrucelli, Leonard
Publicado 2022

MD2202: compensating long-range beam-beam effectin the LHC using DC wires

por Sterbini, Guido, Amorim, David, Arduini, Gianluigi, Bartosik, Hannes, Bruce, Roderik, Buffat, Xavier, Carver, Lee Robert, Cattenoz, Gregory, Effinger, Ewald, Fartoukh, Stephane, Fitterer, Miriam, Fuster Martinez, Nuria, Gasior, Marek, Gonzalez Berges, Manuel, Gorzawski, Arkadiusz, Hemelsoet, Georges-Henry, Hostettler, Michi, Iadarola, Giovanni, Jones, Rhodri, Kaltchev, Dobrin, Karastathis, Nikos, Kostoglou, Sofia, Lamas Garcia, Inigo, Levens, Tom, Levichev, Alexey, Medina Medrano, Luis Eduardo, Mirarchi, Daniele, Olexa, Jakub, Papadopoulou, Parthena Stefania, Papaphilippou, Yannis, Pellegrini, Dario, Pojer, Mirko, Ponce, Laurette, Poyet, Axel, Redaelli, Stefano, Rossi, Adriana, Salvachua Ferrando, Belen Maria, Schmickler, Hermann, Schmidt, Frank, Skoufaris, Kyriacos, Solfaroli Camillocci, Matteo, Tomas Garcia, Rogelio, Trad, Georges, Valishev, Alexander, Valuch, Daniel, Xu, Chen, Zamantzas, Christos, Zisopoulos, Panagiotis
Publicado 2019

A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress

por Morató, Xavier, Marquié, Marta, Tartari, Juan Pablo, Lafuente, Asunción, Abdelnour, Carla, Alegret, Montserrat, Jofresa, Sara, Buendía, Mar, Pancho, Ana, Aguilera, Núria, Ibarria, Marta, Diego, Susana, Cuevas, Rosario, Cañada, Laia, Calvet, Anna, Antonio, Ester Esteban-De, Pérez-Cordón, Alba, Sanabria, Ángela, de Rojas, Itziar, Nuñez-Llaves, Raúl, Cano, Amanda, Orellana, Adelina, Montrreal, Laura, Cañabate, Pilar, Rosende-Roca, Maitée, Vargas, Liliana, Bojaryn, Urszula, Ricciardi, Mario, Ariton, Diana M., Espinosa, Ana, Ortega, Gemma, Muñoz, Nathalia, Lleonart, Núria, Alarcón-Martín, Emilio, Moreno, Mariola, Preckler, Silvia, Tantinya, Natalia, Ramis, Maribel, Nogales, Ana Belen, Seguer, Susanna, Martín, Elvira, Pytel, Vanesa, Valero, Sergi, Gurruchaga, Miren, Tárraga, Lluís, Ruiz, Agustín, Boada, Mercè
Publicado 2023

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

por Taylor, Jack Carson, Heuer, Hilary W., Clark, Annie L., Wise, Amy B., Manoochehri, Masood, Forsberg, Leah, Mester, Carly, Rao, Meghana, Brushaber, Daniell, Kramer, Joel, Welch, Ariane E., Kornak, John, Kremers, Walter, Appleby, Brian, Dickerson, Bradford C., Domoto‐Reilly, Kimiko, Fields, Julie A., Ghoshal, Nupur, Graff‐Radford, Neill, Grossman, Murray, Hall, Matthew GH, Huey, Edward D., Irwin, David, Lapid, Maria I., Litvan, Irene, Mackenzie, Ian R., Masdeu, Joseph C., Mendez, Mario F., Nevler, Naomi, Onyike, Chiadi U., Pascual, Belen, Pressman, Peter, Rankin, Katherine P., Ratnasiri, Buddhika, Rojas, Julio C., Tartaglia, Maria Carmela, Wong, Bonnie, Gorno‐Tempini, Maria Luisa, Boeve, Bradley F., Rosen, Howard J., Boxer, Adam L., Staffaroni, Adam M.
Publicado 2023

Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study

por Lainez, Nuria, García-Donas, Jesús, Esteban, Emilio, Puente, Javier, Sáez, M. Isabel, Gallardo, Enrique, Pinto-Marín, Álvaro, Vázquez-Estévez, Sergio, León, Luis, García-Carbonero, Icíar, Suárez-Rodríguez, Cristina, Molins, Carmen, Climent-Duran, Miguel A., Lázaro-Quintela, Martín, González del Alba, Aranzazu, Méndez-Vidal, María José, Chirivella, Isabel, Afonso, Francisco J., López-Brea, Marta, Sala-González, Nuria, Domenech, Montserrat, Basterretxea, Laura, Santander-Lobera, Carmen, Gil-Arnáiz, Irene, Fernández, Ovidio, Caballero-Díaz, Cristina, Mellado, Begoña, Marrupe, David, García-Sánchez, José, Sánchez-Escribano, Ricardo, Fernández Parra, Eva, Villa Guzmán, José C., Martínez-Ortega, Esther, Belén González, María, Morán, Marina, Suarez-Paniagua, Beatriz, Lecumberri, María J., Castellano, Daniel
Publicado 2016

Human Immunodeficiency Virus/Hepatits C Virus Coinfection in Spain: Elimination Is Feasible, but the Burden of Residual Cirrhosis Will Be Significant

por Berenguer, Juan, Jarrín, Inmaculada, Pérez-Latorre, Leire, Hontañón, Víctor, Vivancos, María J, Navarro, Jordi, Téllez, María J, Guardiola, Josep M, Iribarren, José A, Rivero-Juárez, Antonio, Márquez, Manuel, Artero, Arturo, Morano, Luis, Santos, Ignacio, Moreno, Javier, Fariñas, María C, Galindo, María J, Hernando, María A, Montero, Marta, Cifuentes, Carmen, Domingo, Pere, Sanz, José, Domíngez, Lourdes, Ferrero, Oscar L, De la Fuente, Belén, Rodríguez, Carmen, Reus, Sergio, Hernández-Quero, José, Gaspar, Gabriel, Pérez-Martínez, Laura, García, Coral, Force, Lluis, Veloso, Sergio, Losa, Juan E, Vilaró, Josep, Bernal, Enrique, Arponen, Sari, Ortí, Amat J, Chocarro, Ángel, Teira, Ramón, Alonso, Gerardo, Silvariño, Rafael, Vegas, Ana, Geijo, Paloma, Bisbe, Josep, Esteban, Herminia, González-García, Juan
Publicado 2018

Standardization and Chemical Characterization of Intravenous Therapy in Adult Patients: A Step Further in Medication Safety

por Manrique-Rodríguez, Silvia, Heras-Hidalgo, Irene, Pernia-López, M. Sagrario, Herranz-Alonso, Ana, del Río Pisabarro, M. Camino, Suárez-Mier, M. Belén, Cubero-Pérez, M. Antonia, Viera-Rodríguez, Verónica, Cortés-Rey, Noemí, Lafuente-Cabrero, Elizabeth, Martínez-Ortega, M. Carmen, Bermejo-López, Esther, Díez-Sáenz, Cristina, López-Sánchez, Piedad, Gaspar-Carreño, M. Luisa, Achau-Muñoz, Rubén, Márquez-Peiró, Juan F., Valera-Rubio, Marta, Domingo-Chiva, Esther, Aquerreta-González, Irene, Ariño, Ignacio Pellín, Martín-Delgado, M. Cruz, Herrera-Gutiérrez, Manuel, Gordo-Vidal, Federico, Rascado-Sedes, Pedro, García-Prieto, Emilio, Fernández-Sánchez, Lucas J., Fox-Carpentieri, Sara, Lamela-Piteira, Carlos, Guerra-Sánchez, Luis, Jiménez-Aguado, Miguel, Sanjurjo-Sáez, María
Publicado 2020

Red List assessment of amphibian species of Ecuador: A multidimensional approach for their conservation

por Ortega-Andrade, H. Mauricio, Rodes Blanco, Marina, Cisneros-Heredia, Diego F., Guerra Arévalo, Nereida, López de Vargas-Machuca, Karima Gabriela, Sánchez-Nivicela, Juan C., Armijos-Ojeda, Diego, Cáceres Andrade, José Francisco, Reyes-Puig, Carolina, Quezada Riera, Amanda Belén, Székely, Paul, Rojas Soto, Octavio R., Székely, Diana, Guayasamin, Juan M., Siavichay Pesántez, Fausto Rodrigo, Amador, Luis, Betancourt, Raquel, Ramírez-Jaramillo, Salomón M., Timbe-Borja, Bruno, Gómez Laporta, Miguel, Webster Bernal, Juan Fernando, Oyagata Cachimuel, Luis Alfredo, Chávez Jácome, Daniel, Posse, Valentina, Valle-Piñuela, Carlos, Padilla Jiménez, Daniel, Reyes-Puig, Juan Pablo, Terán-Valdez, Andrea, Coloma, Luis A., Pérez Lara, Ma. Beatriz, Carvajal-Endara, Sofía, Urgilés, Miguel, Yánez Muñoz, Mario H.
Publicado 2021