“…Upon MTD201 injection, a low initial burst of octreotide (<1ng/mL) was followed by a sustained period of release that extended beyond the final sampling point at Day 63. C(max) values of 5.42ng/mL (SC) and 3.68ng/mL (IM) were within the plasma exposure range reported for marketed octreotide products. …”
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“…DISCUSSION: These results indicate that multiple potential mechanisms underlie motivational deficits in schizophrenia spectrum disorders, including processes related to the ability to flexibly modulate learning and decision making according to one’s level of certainty about contingencies in the environment. That is, beyond deficits in reward-seeking behavior, a reduced ability to use uncertainty to modulate learning rates and a reduced tendency to engage in information-seeking behavior may make substantial contributions to negative symptoms in people with psychotic illness and people at risk for psychotic illness. …”
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“…Patients treated with Atrovastatin had significantly lower number of patients with hs-CRP (high-sensitivity C-reactive protein)/C-reactive protein (CRP) level beyond comparable safe limit and relatively better tolerated as opposed to Rosuvastatin-40mg.Thus given the lower price, Atorvastatin 80mg/day appeared to be more cost-effective. …”
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“…Assessment of patient-reported outcomes following concussion may provide valuable insights to direct management plans beyond typical assessments of concussion symptoms or neurocognitive function.…”
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“…Dye contamination was noted on the gauze placed over the smoke evacuator (two cases of skull base surgery); no fluid droplets were identified beyond the nares or the smoke evacuator (two cases of sinus surgery). …”
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“…First, unlike lower frequency fields, MMW do not penetrate beyond the outer skin layers and thus do not expose inner tissues to MMW. …”
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“…In addition, this analysis shows precisely where population groups are located that are particularly likely to under-report COVID-19 symptoms because of low physical access to healthcare facilities. Beyond the COVID-19 response, this study can inform countries’ efforts to improve care for conditions that are common among older adults, such as chronic non-communicable diseases.…”
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“…Biochar supplementation promoted CH(4) production regardless of the source and inclusion level, suggesting that there may be other effects beyond biomass and temperature of production of biochar, highlighting the need to consider other characteristics to better identify the mechanism by which biochar may influence CH(4) production.…”
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“…However, the de-identified nature of the data limits HRSA HAB’s ability to expand beyond year-to-year analyses and conduct additional analyses to evaluate outcomes for clients who are seen in multiple years. …”
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“…For the total trial population, incremental cost-effectiveness ratios were $662/QALY and $13 877/QALY based on the DAWN and DEFUSE 3 trials, respectively. MT with SMC beyond 6 hours had a probability greater than 99.9% of being cost-effective vs SMC alone at a willingness-to-pay threshold of $100 000/QALY. …”
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“…The findings also show that the benefits of improving access to family planning are likely to extend beyond the fertility and health domain by improving other measures of women’s well-being. …”
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“…PD‐L1+ CTCs remained an independent predictor of OS (HR = 3.22, P = 0.010) even after controlling for Model for End‐Stage Liver Disease score (HR = 1.14, P < 0.001), alpha‐fetoprotein (HR = 1.55, P < 0.001), and overall stage/tumor burden (beyond University of California, San Francisco, HR = 7.19, P < 0.001). …”
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“…The characteristics of the multifaceted trust model go beyond being personalized, context-dependent, and transitive. …”
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“…In women who have had GDM, an elevated body mass index (BMI) may have a substantial impact for persistent hyperglycemia in their lives after gestation. Beyond hyperglycemia, increased local oxidative stress directly promotes the formation of Advanced Glycation End-products (AGEs). …”
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“…CONCLUSIONS: Our simple model captures the dynamics of the initial stages of the pandemic, from its exponential beginning to the first peak and beyond, with remarkable precision. As with all epidemiological analyses, unanticipated behavioral changes will result in deviations between projection and observation. …”
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“…However, prenylation inhibitors have pleiotropic effects beyond Ras and non-tolerable side-effects that disfavor further clinical validation. …”
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“…We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. …”
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“…This study determines the real-world and long-term clinical outcomes beyond transition to psychosis in a large cohort of CHR-P individuals. …”
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“…Peer networking provided emotional support beyond that of patient-provider relationships, improving quality of life and care satisfaction. …”
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“…BACKGROUND: The COVID-19 pandemic led to unprecedented mitigation efforts that disrupted the daily lives of millions. Beyond the general health repercussions of the pandemic itself, these measures also present a challenge to the world’s mental health and health care systems. …”
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