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2101
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2102“…The mechanisms that connect the underlying genetic defects to disease pathogenesis are poorly understood, but their exploration is shedding new light on interesting cell biological processes and suggesting novel therapeutic targets.…”
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2103“…An aspect of their complex biology is the paradox that, depending on context, type I interferons can be anti-inflammatory and tissue protective or can be proinflammatory and promote autoimmunity. …”
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2104“…See research article: http://www.biomedcentral.com/1471-2105/11/582/abstract/ Ever since the rise of systems biology at the end of the last century, mathematical representations of biological systems and their activities have flourished. …”
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2105“…Systems biology is an approach to the science that views biology as an information science, studies biological systems as a whole and their interactions with the environment. …”
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2106“…The inevitable role bioinformatics plays in modern systems biology puts mathematical and computational sciences as an equal partner to analytical and experimental biology. …”
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2107por Sander, P Martin, Christian, Andreas, Clauss, Marcus, Fechner, Regina, Gee, Carole T, Griebeler, Eva-Maria, Gunga, Hanns-Christian, Hummel, Jürgen, Mallison, Heinrich, Perry, Steven F, Preuschoft, Holger, Rauhut, Oliver W M, Remes, Kristian, Tütken, Thomas, Wings, Oliver, Witzel, Ulrich“…We review the biology of sauropod dinosaurs in detail and posit that sauropod gigantism was made possible by a specific combination of plesiomorphic characters (phylogenetic heritage) and evolutionary innovations at different levels which triggered a remarkable evolutionary cascade. …”
Publicado 2011
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2108
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2109
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2110por Chen, Jieming“…The Yale Systems Biology Institute (YSBI) sponsored its first symposium at the university’s West Campus in October 2010. …”
Publicado 2011
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2111por Silveira e Souza, Adriana Maria Mariano, Mazucato, Vivian Marino, Jamur, Maria Célia, Oliver, Constance“…Despite their growing significance in physiological and pathological conditions, much still remains to be learned about mast cell biology. This paper presents evidence that lipid rafts or raft components modulate many of the biological processes in mast cells, such as degranulation and endocytosis, play a role in mast cell development and recruitment, and contribute to the overall preservation of mast cell structure and organization.…”
Publicado 2011
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2112
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2113“…Not surprisingly, the biological properties of APP have also been the subject of great interest and intense investigations. …”
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2114
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2115por Sedwick, CaitlinEnlace del recurso
Publicado 2011
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2116“…In the past ten years we have made exceptional progresses in the understanding of RCC biology, particularly by recognizing the crucial pathogenetic role of activation of the HIF/VEGF and mTOR pathways. …”
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2117“…Here we discuss these challenges, and show how integrative computational biology can help diminish them by creating new software tools, analytical methods, and data standards. …”
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2118por Steimer, Thierry“…Our current knowledge of the biological bases of fear and anxiety is already impressive, and further progress toward models or theories integrating contributions from the medical, biological, and psychological sciences can be expected.…”
Publicado 2002
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2119“…This review summarizes research pertaining to JSRV-induced pathogenesis, Env transformation, and other aspects of JSRV biology.…”
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2120“…Here we will review—starting with a deeper look into retroviral biology—how Murine Leukemia Virus (MLV), a simple gammaretrovirus, can be converted into an efficient vehicle of genetic therapeutics. …”
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