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3421
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3422por Clermont, Gilles, Auffray, Charles, Moreau, Yves, Rocke, David M, Dalevi, Daniel, Dubhashi, Devdatt, Marshall, Dana R, Raasch, Peter, Dehne, Frank, Provero, Paolo, Tegner, Jesper, Aronow, Bruce J, Langston, Michael A, Benson, Mikael“…Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now becoming apparent. …”
Publicado 2009
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3423
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3424“…Significant technical advances in imaging, molecular biology and genomics have fueled a revolution in cell biology, in that the molecular and structural processes of the cell are now visualized and measured routinely. …”
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3425“…Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological “devices” that exhibit predictable behavior. …”
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3426por Cao, Hongqing, Romero-Campero, Francisco J., Heeb, Stephan, Cámara, Miguel, Krasnogor, Natalio“…This paper proposes a new methodology for the automated design of cell models for systems and synthetic biology. Our modelling framework is based on P systems, a discrete, stochastic and modular formal modelling language. …”
Publicado 2010
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3427
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3428
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3429“…A central challenge in computational modeling of biological systems is the determination of the model parameters. …”
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3430
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3431
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3432por Sabatini, David“…Philip Siekevitz, an Emeritus Professor at the Rockefeller University who madepioneering contributions to the development of modern cell biology, passed awayon December 5th, 2009. He was a creative and enthusiastic scientist, as well asa great experimentalist who throughout his lifetime transmitted the joy ofpracticing science and the happiness that comes with the acquisition of newknowledge. …”
Publicado 2010
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3433
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3434
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3435“…A recent article in BMC Biology illustrates the use of a systems-biology approach to integrate data across the transcriptome, proteome and metabolome of budding yeast in order to dissect the relationship between nutrient conditions and cell growth. …”
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3436
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3437por Bertelli, Claire, Collyn, François, Croxatto, Antony, Rückert, Christian, Polkinghorne, Adam, Kebbi-Beghdadi, Carole, Goesmann, Alexander, Vaughan, Lloyd, Greub, Gilbert“…As a whole, the availability of the W. chondrophila genome opens new possibilities in Chlamydiales research, providing new insights into the evolution of members of the order Chlamydiales and the biology of the Waddliaceae.…”
Publicado 2010
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3438“…During the past years, there was an increased interest in RVFV epidemiology, molecular biology, and virulence mechanisms. Here, we will try to provide an overview over the basic features of this significant pathogen, and review the latest developments in this highly active research field.…”
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3439
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3440por Mardis, Elaine R“…Unbiased sequencing and analysis of human tumors is revealing unsuspected somatic changes that, upon further study, are elucidating aspects of tumor biology and identifying new biomarkers.…”
Publicado 2010
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