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3721“…The molecular function of HDACs have been extensively characterized by various approaches including chemical, molecular, and structural biology, which demonstrated that HDACs regulate cell proliferation, differentiation, and metabolic homeostasis, and that their alterations are deeply involved in various human disorders including cancer. …”
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3722“…Here, we briefly describe the biology of hypoxia in cervix tumors of relevance for imaging, and evaluate positron emission tomography (PET) and magnetic resonance imaging (MRI) techniques that have shown promise for assessing hypoxia in a clinical setting. …”
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3723
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3724“…As illustrated by the mitochondrion and the eukaryotic cell, little in biology makes sense except in light of mutualism. …”
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3725por Friedenreich, Christine M., Shaw, Eileen, Neilson, Heather K., Brenner, Darren R.“…However, there is considerably less evidence relating physical activity to cancer recurrence and the biologic mechanisms underlying this association remain unclear. …”
Publicado 2017
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3726“…Zebrafish are missing homologs of some human proteins and (of particular interest) several members of the matrix metalloproteinase (MMP) family of proteases, which are known for their importance in tumour biology. This review draws attention to the implicit evolutionary experiment taking place when the molecular ecology of the xenograft host is significantly different than that of the donor.…”
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3727“…Under the support of China National Basic Research 973 Project, we developed synthetic biology methods to diversify the PHA structures into homo-, random, block polymers with improved properties to better meet various application requirements. …”
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3728“…Synthetic biology is capable of delivering new solutions to key challenges spanning the bioeconomy, both nationally and internationally. …”
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3729por Darling, Sarah, Fielding, Andrew B., Sabat-Pośpiech, Dorota, Prior, Ian A., Coulson, Judy M.“…As potentially druggable enzymes, disease-associated DUBs are of increasing interest as pharmaceutical targets. The biology, structure and regulation of DUBs have been extensively reviewed elsewhere, so here we focus specifically on roles of DUBs in regulating cell cycle processes in mammalian cells. …”
Publicado 2017
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3730“…In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. …”
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3731“…In this review, we explore the clinical and pathological features of DCIS, fundamental elements of DCIS biology including gene expression and genetic events, the relationship of DCIS with recurrence and invasive breast cancer, and the interaction of DCIS with the microenvironment. …”
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3732por da Silva Dantas, Alessandra, Lee, Kathy K, Raziunaite, Ingrida, Schaefer, Katja, Wagener, Jeanette, Yadav, Bhawna, Gow, Neil AR“…In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. …”
Publicado 2016
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3733“…Understanding which mechanical properties can interfere with the cellular and molecular biology of Schwann cell during development, myelination and following injuries opens new insights in the regulation of PNS development and treatment approaches in peripheral neuropathies.…”
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3734“…Our review summarizes the recent results of PPV research and aims to give a comprehensive update on the present understanding of PPV biology.…”
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3735por Coffman, James A, Rieger, Sandra, Rogers, Aric N, Updike, Dustin L, Yin, Viravuth P“…The Symposium on the Comparative Biology of Tissue Repair, Regeneration and Aging, held 26 June to 28 June 2015 at the MDI Biological Laboratory in Salisbury Cove, Maine, brought together a diverse group of biologists with a common interest in understanding why regenerative capacity varies among animal species, why it is progressively lost in senescence, and how answers obtained from studies that address those questions might be applied in regenerative medicine.…”
Publicado 2016
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3736por Skrzypek, Marek S, Nash, Robert S, Wong, Edith D, MacPherson, Kevin A, Hellerstedt, Sage T, Engel, Stacia R, Karra, Kalpana, Weng, Shuai, Sheppard, Travis K, Binkley, Gail, Simison, Matt, Miyasato, Stuart R, Cherry, J Michael“…To build such a bridge between biological kingdoms, SGD is curating data regarding yeast-human complementation, in which a human gene can successfully replace the function of a yeast gene, and/or vice versa. …”
Publicado 2018
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3738“…Rapidly varying culture decreases the probability of biological adaptation. However, we show that this effect declines with population size and with stronger links between biology and culture: in realistically sized finite populations, stochastic effects can carry cognitive specialisations to fixation in the face of variable culture, especially if the effects of those specialisations are amplified through cultural evolution. …”
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3739“…The study of host–pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. …”
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3740“…In this context, we submit that telomere biology represents a process of particular interest in humans because, firstly, this system represents among the most salient antecedent cellular phenotypes for common age-related disorders; secondly, its initial (newborn) setting appears to be particularly important for its long-term effects; and thirdly, its initial setting appears to be plastic and under developmental regulation. …”
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