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4621por Hertler, StevenEnlace del recurso
Publicado 2016
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4622por Sarma, Gopal P., Jacobs, Travis W., Watts, Mark D., Ghayoomie, S. Vahid, Larson, Stephen D., Gerkin, Richard C.“…As computational models and methods have become increasingly common in the biological sciences, it is important to examine how these practices can accelerate biological software development and improve research quality. …”
Publicado 2016
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4623“…Due to its extraordinary heterogeneity and complexity, cancer is often proposed as a model case of a systems biology disease or network disease. There is a critical need of effective biomarkers for cancer diagnosis and/or outcome prediction from system level analyses. …”
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4624“…Decades of research have established that the m7G cap serves as a unique molecular module that recruits cellular proteins and mediates cap-related biological functions such as pre-mRNA processing, nuclear export and cap-dependent protein synthesis. …”
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4625por Benedict, Adriana LeeEnlace del recurso
Publicado 2014
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4626por Spakowitz, Andrew J.Enlace del recurso
Publicado 2016
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4627“…The computational design of dynamical systems is an important emerging task in synthetic biology. Given desired properties of the behaviour of a dynamical system, the task of design is to build an in-silico model of a system whose simulated be- haviour meets these properties. …”
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4628por Dennis, Kristine K., Auerbach, Scott S., Balshaw, David M., Cui, Yuxia, Fallin, Margaret Daniele, Smith, Martyn T., Spira, Avrum, Sumner, Susan, Miller, Gary W.“…The exposome and biology are interactive—changes in biology due to the environment change one’s vulnerability to subsequent exposures. …”
Publicado 2016
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4629“…We evaluate prominent LNA and GNA methods on synthetic and real-world biological networks. We study the effect on alignment quality of using different interaction types and confidence levels. …”
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4630“…BACKGROUND: Biological networks provide great potential to understand how cells function. …”
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4631“…LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors. …”
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4632por Epand, Richard M., So, Vincent, Jennings, William, Khadka, Bijendra, Gupta, Radhey S., Lemaire, MathieuMaterias: “…Cell and Developmental Biology…”
Publicado 2016
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4633por Arivarasan, K, Bhardwaj, Vaishali, Sud, Sukrit, Sachdeva, Sanjeev, Puri, Amarender Singh“…Despite limited published literature, biologics have caused a paradigm shift in the management of this difficult-to-treat skin condition. …”
Publicado 2016
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4635por Vasiev, Bakhtier“…Developmental processes in biology are underlined by proliferation, differentiation and migration of cells. …”
Publicado 2016
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4636“…[Image: see text] Heparin is a naturally occurring, highly sulfated polysaccharide that plays a critical role in a range of different biological processes. Therapeutically, it is mostly commonly used as an injectable solution as an anticoagulant for a variety of indications, although it has also been employed in other forms such as coatings on various biomedical devices. …”
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4637por Batzli, Janet M., Knight, Jennifer K., Hartley, Laurel M., Maskiewicz, April Cordero, Desy, Elizabeth A.“…Threshold concepts have been referred to as “jewels in the curriculum”: concepts that are key to competency in a discipline but not taught explicitly. In biology, researchers have proposed the idea of threshold concepts that include such topics as variation, randomness, uncertainty, and scale. …”
Publicado 2016
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4638“…Recent advancements have shown their biological properties in conferring protection against cancer, cardiovascular diseases, neurodegeneration, oxidative stress and immune regulation. …”
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4639“…Recent studies in animal models indicate that the lineage of the tumour-initiating cell may contribute to the biological and genomic phenotype of glioblastoma. These results suggest that the cell of origin may not only serve as a source of diversity for these tumours, but may also provide new avenues for improved diagnostics and therapeutic targeting that may prolong the lives of patients.…”
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