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  1. 4681
    por Li, Yi, Wang, Feihu, Cui, Honggang
    Publicado 2016
    “…The demand for therapeutic biologics has rapidly grown over recent decades, creating a dramatic shift in the pharmaceutical industry from small molecule drugs to biological macromolecular therapeutics. …”
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    Peptide‐based supramolecular hydrogels for delivery of biologics
  2. 4682
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    Medicinal, biological and phytochemical properties of Gentiana species
  3. 4683
    “…A central question in biological water splitting concerns the oxidation states of the manganese ions that comprise the oxygen-evolving complex of photosystem II. …”
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    Metal oxidation states in biological water splitting
  4. 4684
    “…OBJECTIVE: The present study aims to address emerging biological approaches to GBS while considering their efficiency and safety in treating the disease. …”
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    Biological Drugs in Guillain-Barré Syndrome: An Update
  5. 4685
    por Bromfield, W. Drew, Gold, Jason M.
    Publicado 2017
    “…We relate our findings to previous proposals of a distinction between form-based and motion-based mechanisms in biological-motion perception.…”
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    Efficiencies for parts and wholes in biological-motion perception
  6. 4686
    “…The hCG molecule is produced by a variety of organs, exists in various forms, exerts vital biological functions, and has various clinical roles ranging from diagnosis and monitoring of pregnancy and pregnancy-related disorders to cancer surveillance. …”
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    hCG: Biological Functions and Clinical Applications
  7. 4687
    por Hughes, Michael E., Abruzzi, Katherine C., Allada, Ravi, Anafi, Ron, Arpat, Alaaddin Bulak, Asher, Gad, Baldi, Pierre, de Bekker, Charissa, Bell-Pedersen, Deborah, Blau, Justin, Brown, Steve, Ceriani, M. Fernanda, Chen, Zheng, Chiu, Joanna C., Cox, Juergen, Crowell, Alexander M., DeBruyne, Jason P., Dijk, Derk-Jan, DiTacchio, Luciano, Doyle, Francis J., Duffield, Giles E., Dunlap, Jay C., Eckel-Mahan, Kristin, Esser, Karyn A., FitzGerald, Garret A., Forger, Daniel B., Francey, Lauren J., Fu, Ying-Hui, Gachon, Frédéric, Gatfield, David, de Goede, Paul, Golden, Susan S., Green, Carla, Harer, John, Harmer, Stacey, Haspel, Jeff, Hastings, Michael H., Herzel, Hanspeter, Herzog, Erik D., Hoffmann, Christy, Hong, Christian, Hughey, Jacob J., Hurley, Jennifer M., de la Iglesia, Horacio O., Johnson, Carl, Kay, Steve A., Koike, Nobuya, Kornacker, Karl, Kramer, Achim, Lamia, Katja, Leise, Tanya, Lewis, Scott A., Li, Jiajia, Li, Xiaodong, Liu, Andrew C., Loros, Jennifer J., Martino, Tami A., Menet, Jerome S., Merrow, Martha, Millar, Andrew J., Mockler, Todd, Naef, Felix, Nagoshi, Emi, Nitabach, Michael N., Olmedo, Maria, Nusinow, Dmitri A., Ptáček, Louis J., Rand, David, Reddy, Akhilesh B., Robles, Maria S., Roenneberg, Till, Rosbash, Michael, Ruben, Marc D., Rund, Samuel S.C., Sancar, Aziz, Sassone-Corsi, Paolo, Sehgal, Amita, Sherrill-Mix, Scott, Skene, Debra J., Storch, Kai-Florian, Takahashi, Joseph S., Ueda, Hiroki R., Wang, Han, Weitz, Charles, Westermark, Pål O., Wijnen, Herman, Xu, Ying, Wu, Gang, Yoo, Seung-Hee, Young, Michael, Zhang, Eric Erquan, Zielinski, Tomasz, Hogenesch, John B.
    Publicado 2017
    “…Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. …”
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    Guidelines for Genome-Scale Analysis of Biological Rhythms
  8. 4688
    “…The study of newly evolved genes has long fascinated biologists, but large-scale studies of their expression dynamics and molecular function have provided conflicting interpretations of their biological impact. In this issue of Genes & Development, Kondo and colleagues (pp. 1841–1846) use extensive transcriptomic resources and current CRISPR/Cas9 technology to re-examine the functional impact of newly evolved genes in Drosophila and find evidence of their biological impact on male reproduction.…”
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    Out of the testis: biological impacts of new genes
  9. 4689
    “…Measurement uncertainties are inherent to assessment of biological indices of water bodies. The effect of these uncertainties on the probability of misclassification of ecological status is the subject of this paper. …”
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    Probability of misclassifying biological elements in surface waters
  10. 4690
    “…Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. …”
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    Biological potential of thiazolidinedione derivatives of synthetic origin
  11. 4691
    “…Herein, we discuss the biological and clinical implications of comorbidities in the pathogenesis, progression, and clinical management, with an emphasis on personalized medicine applications for PD.…”
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    Biological and Clinical Implications of Comorbidities in Parkinson’s Disease
  12. 4692
    por Pisetsky, David S.
    Publicado 2017
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    The biological functions of DNA: from the sublime to the slime
  13. 4693
    “…It is predicted that ethyl acetate, chloroform, and n-butanol extracts of H. rosea contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities. …”
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    In Vitro Biological Screening of Hartmannia rosea Extracts
  14. 4694
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    Discovery and Biological Evaluation of Natural Phenolic Antioxidants
  15. 4695
    “…Current biological treatments for non-healing wounds aim to address the common deviations in healing mechanisms, mainly inflammation, inadequate angiogenesis and reduced synthesis of extracellular matrix. …”
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    Adjuvant Biological Therapies in Chronic Leg Ulcers
  16. 4696
    por He, Jing, Li, Zhanguo
    Publicado 2017
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    An era of biological treatment in systemic lupus erythematosus
  17. 4697
    “…We demonstrate proof-of-concept for three biologics co-production strategies: (i) inducible expression of multiple biologics and control over the ratio between biologic drugs produced together; (ii) consolidated bioprocessing; and (iii) co-expression and co-purification of a mixture of two monoclonal antibodies. …”
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    Versatile and on-demand biologics co-production in yeast
  18. 4698
    “…Though relatively stable in water and phosphate buffered saline, silica nanoparticles are eroded by biological media, leading to the exposure of AgNDs from AgND@SiO(2) nanoparticles and the quenching of nanodot luminescence. …”
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    Silica nanoparticle stability in biological media revisited
  19. 4699
    “…Finally, the field of chronopharmacology uses these concepts for delivering drugs in synchrony with biological rhythms.…”
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    Biological clocks: their relevance to immune-allergic diseases
  20. 4700
    “…[Image: see text] Whereas 400 million distinct compounds are now purchasable within the span of a few weeks, the biological activities of most are unknown. To facilitate access to new chemistry for biology, we have combined the Similarity Ensemble Approach (SEA) with the maximum Tanimoto similarity to the nearest bioactive to predict activity for every commercially available molecule in ZINC. …”
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    Predicted Biological Activity of Purchasable Chemical Space
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