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4681“…The demand for therapeutic biologics has rapidly grown over recent decades, creating a dramatic shift in the pharmaceutical industry from small molecule drugs to biological macromolecular therapeutics. …”
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4683por Krewald, Vera, Retegan, Marius, Cox, Nicholas, Messinger, Johannes, Lubitz, Wolfgang, DeBeer, Serena, Neese, Frank, Pantazis, Dimitrios A.“…A central question in biological water splitting concerns the oxidation states of the manganese ions that comprise the oxygen-evolving complex of photosystem II. …”
Publicado 2015
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4684por Motamed-Gorji, Nazgol, Matin, Nassim, Tabatabaie, Omidreza, Pavone, Piero, Romano, Catia, Falsaperla, Raffaele, Vitaliti, Giovanna“…OBJECTIVE: The present study aims to address emerging biological approaches to GBS while considering their efficiency and safety in treating the disease. …”
Publicado 2017
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4685“…We relate our findings to previous proposals of a distinction between form-based and motion-based mechanisms in biological-motion perception.…”
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4686por Nwabuobi, Chinedu, Arlier, Sefa, Schatz, Frederick, Guzeloglu-Kayisli, Ozlem, Lockwood, Charles Joseph, Kayisli, Umit Ali“…The hCG molecule is produced by a variety of organs, exists in various forms, exerts vital biological functions, and has various clinical roles ranging from diagnosis and monitoring of pregnancy and pregnancy-related disorders to cancer surveillance. …”
Publicado 2017
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4687por Hughes, Michael E., Abruzzi, Katherine C., Allada, Ravi, Anafi, Ron, Arpat, Alaaddin Bulak, Asher, Gad, Baldi, Pierre, de Bekker, Charissa, Bell-Pedersen, Deborah, Blau, Justin, Brown, Steve, Ceriani, M. Fernanda, Chen, Zheng, Chiu, Joanna C., Cox, Juergen, Crowell, Alexander M., DeBruyne, Jason P., Dijk, Derk-Jan, DiTacchio, Luciano, Doyle, Francis J., Duffield, Giles E., Dunlap, Jay C., Eckel-Mahan, Kristin, Esser, Karyn A., FitzGerald, Garret A., Forger, Daniel B., Francey, Lauren J., Fu, Ying-Hui, Gachon, Frédéric, Gatfield, David, de Goede, Paul, Golden, Susan S., Green, Carla, Harer, John, Harmer, Stacey, Haspel, Jeff, Hastings, Michael H., Herzel, Hanspeter, Herzog, Erik D., Hoffmann, Christy, Hong, Christian, Hughey, Jacob J., Hurley, Jennifer M., de la Iglesia, Horacio O., Johnson, Carl, Kay, Steve A., Koike, Nobuya, Kornacker, Karl, Kramer, Achim, Lamia, Katja, Leise, Tanya, Lewis, Scott A., Li, Jiajia, Li, Xiaodong, Liu, Andrew C., Loros, Jennifer J., Martino, Tami A., Menet, Jerome S., Merrow, Martha, Millar, Andrew J., Mockler, Todd, Naef, Felix, Nagoshi, Emi, Nitabach, Michael N., Olmedo, Maria, Nusinow, Dmitri A., Ptáček, Louis J., Rand, David, Reddy, Akhilesh B., Robles, Maria S., Roenneberg, Till, Rosbash, Michael, Ruben, Marc D., Rund, Samuel S.C., Sancar, Aziz, Sassone-Corsi, Paolo, Sehgal, Amita, Sherrill-Mix, Scott, Skene, Debra J., Storch, Kai-Florian, Takahashi, Joseph S., Ueda, Hiroki R., Wang, Han, Weitz, Charles, Westermark, Pål O., Wijnen, Herman, Xu, Ying, Wu, Gang, Yoo, Seung-Hee, Young, Michael, Zhang, Eric Erquan, Zielinski, Tomasz, Hogenesch, John B.“…Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. …”
Publicado 2017
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4688“…The study of newly evolved genes has long fascinated biologists, but large-scale studies of their expression dynamics and molecular function have provided conflicting interpretations of their biological impact. In this issue of Genes & Development, Kondo and colleagues (pp. 1841–1846) use extensive transcriptomic resources and current CRISPR/Cas9 technology to re-examine the functional impact of newly evolved genes in Drosophila and find evidence of their biological impact on male reproduction.…”
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4689“…Measurement uncertainties are inherent to assessment of biological indices of water bodies. The effect of these uncertainties on the probability of misclassification of ecological status is the subject of this paper. …”
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4690“…Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. …”
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4691“…Herein, we discuss the biological and clinical implications of comorbidities in the pathogenesis, progression, and clinical management, with an emphasis on personalized medicine applications for PD.…”
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4692por Pisetsky, David S.Enlace del recurso
Publicado 2017
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4693por Rashid, Rehana, Kalsoom Khan, Abida, Ul Haq, Ihsan, Mir, Sadullah, Mehmood, Sadaf, Lu, Yi, Murtaza, Ghulam“…It is predicted that ethyl acetate, chloroform, and n-butanol extracts of H. rosea contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities. …”
Publicado 2017
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4695por Burgos-Alonso, Natalia, Lobato, Igone, Hernández, Igone, Sebastian, Kepa San, Rodríguez, Begoña, Grandes, Gontzal, Andia, Isabel“…Current biological treatments for non-healing wounds aim to address the common deviations in healing mechanisms, mainly inflammation, inadequate angiogenesis and reduced synthesis of extracellular matrix. …”
Publicado 2017
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4697por Cao, Jicong, Perez-Pinera, Pablo, Lowenhaupt, Ky, Wu, Ming-Ru, Purcell, Oliver, de la Fuente-Nunez, Cesar, Lu, Timothy K.“…We demonstrate proof-of-concept for three biologics co-production strategies: (i) inducible expression of multiple biologics and control over the ratio between biologic drugs produced together; (ii) consolidated bioprocessing; and (iii) co-expression and co-purification of a mixture of two monoclonal antibodies. …”
Publicado 2018
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4698“…Though relatively stable in water and phosphate buffered saline, silica nanoparticles are eroded by biological media, leading to the exposure of AgNDs from AgND@SiO(2) nanoparticles and the quenching of nanodot luminescence. …”
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4699“…Finally, the field of chronopharmacology uses these concepts for delivering drugs in synchrony with biological rhythms.…”
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4700por Irwin, John J., Gaskins, Garrett, Sterling, Teague, Mysinger, Michael M., Keiser, Michael J.“…[Image: see text] Whereas 400 million distinct compounds are now purchasable within the span of a few weeks, the biological activities of most are unknown. To facilitate access to new chemistry for biology, we have combined the Similarity Ensemble Approach (SEA) with the maximum Tanimoto similarity to the nearest bioactive to predict activity for every commercially available molecule in ZINC. …”
Publicado 2017
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