“…Biological systems are dynamic and display heterogeneity at all levels. …”
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“…This article reviews the mechanism of action and indications for approved biologics and discusses what should be considered when choosing biologics.…”
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“…Thus, rational drug discovery and synthetic biological design is difficult. We suggest that a four-pronged interdisciplinary approach merging biology and electronics can help: (1) The mapping of biological circuits to electronic circuits via quantitatively exact schematics; (2) The use of existing electronic circuit software for hierarchical modeling, design, and analysis with such schematics; (3) The use of cytomorphic electronic hardware for rapid stochastic simulation of circuit schematics and associated parameter discovery to fit measured biological data; (4) The use of bio-electronic reporting circuits rather than bio-optical circuits for measurement. …”
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“…In the last decade, biological drugs have rapidly proliferated and have now become an important therapeutic modality. …”
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“…Furthermore, these proteins are easy to produce, form pores with defined sizes, and can be easily manipulated with standard molecular biology techniques. The range of possible analytes can be extended by using externally added adapter molecules. …”
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“…In the absence of face-to-face meetings, FDA and industry implemented regulatory workarounds to maintain drug and biologics approvals. These could be here to stay.…”
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“…Biologics are drugs that are derived or synthesized from biological sources. …”
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“…Although our understanding of the molecular biological mechanisms of ameloblastoma is still insufficient, there have been many recent reports of new molecular biological findings on ameloblastoma. …”
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“…Recently, there has been a soaring interest in the biological basis of anxiety disorders, which is reflected in an increasing number of articles related to the topic. …”
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“…We introduced conflicts between biological features of the walker (i.e., facing and articulation) and the direction of scene-relative motion. …”
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“…Moreover, with many developments in biotechnology relying on organosilicon materials, it becomes important to scrutinize the potential effect that silicone leaching may have on biological systems.…”
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