“…BACKGROUND: Ibalizumab (IBA) is a long-acting humanized monoclonal antibody that binds domain 2 of the CD4 receptor and blocks HIV-1 infection of host cells. TMB-301 was a 24-week, Phase 3 clinical trial conducted in 40 heavily treatment-experienced patients with multidrug-resistant (MDR) HIV-1 investigating the safety, efficacy and tolerability of IBA. …”
Enlace del recurso
Enlace del recurso

“…BACKGROUND: JS001, a humanized IgG(4) monoclonal antibody against the programmed death-1 (PD-1) receptor, blocks the interaction of PD-1 with its ligands and promotes T cell activation in preclinical studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PET imaging and biodistribution studies were performed in male immunocompromised mice bearing PC-3 prostate cancer xenografts. Blocking experiments were performed with coinjection of [d-Phe(6),Leu-NHEt(13),des-Met(14)]bombesin(6-14). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We propose transitional pathways from the cosmic building blocks of life to the complex prebiotic organic chemistry that led to the origin of information systems. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pep45-65-NH2 suppressed MSTN activity with a potency similar to that of MBP-Pro45-65 but did not suppress GDF11, or activin A. Pep45-65-NH2 blocked MSTN-induced Smad2 phosphorylation in HepG2 cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The collagen binding activity directs PTH analogs to the bone matrix where it blocks PTHrP action. PTH(7-33)-CBD is an amino truncated PTHrP antagonist fused to the CBD that we previously showed reduced metastatic tumor burden in bone and prevented bone destruction. …”
Enlace del recurso
Enlace del recurso

“…These 10 clinics are randomly assigned to 5 blocks to receive the TMI implementation intervention (workshop and trigger-based coaching guided by local implementation teams) utilizing the dynamic wait-listed controlled design. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The randomization sequence will be stratified by city and use random permuted blocks of sizes 2 and 4. Participants randomized to the control condition will view a weekly email newsletter on topics related to HIV, with the exception of ART adherence, for 5 months. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Specifically, ITCH silencing or CI blocked 9F7-F11-induced caspase-8-mediated apoptosis of tumor cells, and restored c-FLIP expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Alcohol and placebo conditions were counter-balanced across participants as were the presentation the blocks of evocative and neutral partner stimuli and emotion-regulation condition (watch vs. do not react). …”
Enlace del recurso
Enlace del recurso

“…LARGE SCALE DATA: N/A LIMITATIONS, REASONS FOR CAUTION: Tissue stiffness was derived by ex vivo measurements on blocks of fresh tissue in the absence of blood flow. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The MAGPIE (Magnesium sulphate for Prevention of Eclampsia) trial stated that the risk of developing convulsions was lowered significantly (58%) in severe pre-eclampsia patients who received magnesium sulfate in comparison to the placebo group.(1) The exact mechanism of action of magnesium sulfate (MgSO4) is not completely understood, blocking calcium channels and decreasing availability of calcium for smooth muscle contractions has been suggested. …”
Enlace del recurso
Enlace del recurso

“…ASPH fosters primary tumor development and pulmonary metastasis in PDX models of PDAC, which is blocked by a leading compound specifically against ASPH enzymatic activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Objective: To establish baseline ratings of body satisfaction among gender-diverse youth prior to puberty blocking medication. Methods: Subjects were recruited from the gender health clinic at Riley Hospital for Children beginning in January 2018. …”
Enlace del recurso
Enlace del recurso

“…Aromatase inhibitor (AI) is a drug that blocks the conversion of androgens to estrogens, originally approved by FDA as a treatment of breast cancer in postmenopausal women. …”
Enlace del recurso
Enlace del recurso

“…A total of 976 pigs (PIC 327 × Camborough; PIC, Hendersonville, TN; initially 22.0 ± 1.53 kg body weight [BW]) were used in a 160-d growth study to evaluate the effects of increasing space allowance and varying marketing strategies on growth performance of pigs raised to market weights of ~165 kg. Pens of pigs were blocked by location within the barn and allotted to one of six treatments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On d 21 post-weaning, pens were blocked by BW and randomly allotted to 1 of 8 (experiment 1) or 7 (experiment 2) dietary treatments with five pigs per pen and eight pens per treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recommendations for epidemic prevention and control strategies are: 1) Large droplets are the main conflict in disease transmission; thus, even if they are blocked by a homemade mask initially, it significantly contains the epidemic. 2) The early phase of contact, such as close-contact and short-range transmission, has the highest infection risk; therefore, social distancing can effectively keep the susceptible population from inhaling active viruses. 3) The risk of the fomite route depends on the time in contact with infectious viruses; thus, it is important to promote good health habits (including frequent hand washing, no-eye rubbing, coughing etiquette, normalization of surface cleaning), although blind and excessive disinfection measures are not advisable. 4) Compared with the large droplets, the small droplets have larger numbers but carry fewer viruses and are more prone to die through evaporation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, VIIRS’ constant ~ 700 m resolution can provide a more detailed representation of population distribution in peri-urban and rural areas where aggregated census blocks lack comparable spatial detail. By varying the low luminance threshold of VIIRS-derived night light, we depict spatial networks of lighted development of varying degrees of connectivity within which populations are distributed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, TNF-α neutralization blocked CS-associated leukocyte activation (P < .05); IL-1β neutralization also diminished leukocyte adhesion (P < .05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso