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  1. 120821
    “…Abatacept is a monocolonal antibody which binds to CD80 and CD86 on antigen presenting cells (APCs) blocking T-cell activity. Since starting Abatacept treatment the patient's hypercalcemia has improved. …”
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    ODP095 HYPERCALCEMIA FROM SILICONE BUTTOCK INJECTION INDUCED GRANULOMA.
  2. 120822
    “…By competitively binding to the IgG binding site on FcRn, batoclimab blocks FcRn-mediated recycling of IgG, resulting in increased elimination and decreased levels of IgG. …”
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    ODP509 Proof-of-concept, Multicenter, Open-Label Phase 2a Study of Batoclimab in Active and Moderate-to-Severe Thyroid Eye Disease
  3. 120823
    “…Notably, concomitant isoproterenol or salbutamol treatment blocks propionic acid-induced signaling via the FFAR3 in H9c2 cardiomyocytes, indicating negative regulation of FFAR3 by catecholamines via the β(2)AR. …”
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    PMON181 RGS4 Is Essential For The Sympathetic Regulation of The Short-chain Fatty Acid Receptor FFAR3 In The Heart
  4. 120824
    “…INTRODUCTION: Nivolumab is a human immunoglobulin G4 (IgG4) antibody which binds to programmed cell death receptor-1 (PD-1) and blocks the binding of PD-1 to either the PD-ligand 1 (PD-L1) or PD-L2 expressed on the surface of cancer cells. …”
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    ODP068 A Case Report of Nivolumab Associated Hypercalcemia
  5. 120825
    “…We hypothesize that blocking PTH/PTHrP action via a PTHR1 antagonist may provide an improved therapeutic mechanism to treat PHPT and HHM, and potentially other diseases of hypercalcemia. …”
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    LBSAT142 Discovery And Characterization Of A Potent And Orally Bioavailable Parathyroid Hormone Receptor Type-1 (PTHR1) Antagonist For The Treatment Of Hypercalcemia
  6. 120826
    “…Taken together, these data might pave the way for new therapeutical approaches by blocking IL-22 or its downstream signaling in HCC. …”
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    A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma
  7. 120827
    “…Host innate and adaptive immune responses can be subverted by C. gattii, that blocks the differentiation of T helper (Th) 1 and Th17 cells, which are involved in the protection against cryptococcosis. …”
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    Adjuvant Pam3CSk4 does not improve the immunization against Cryptococcus gattii infection in C57BL/6 mice
  8. 120828
    “…PET imaging experiments with CD1 mice revealed a higher brain uptake and retention for (R)-[(18)F]OF-NB1, as assessed by visual inspection and volumes of distribution from Logan graphical analyses. In vivo blocking experiments with sigma2 ligand, FA10, did not result in a significant reduction of the brain signal for both enantiomers, thus corroborating the selectivity over sigma2 receptors. …”
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    Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[(18)F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors
  9. 120829
    “…Our data confirmed that the national stewardship intervention seems to be successful in blocking antibiotic resistance determinants and that continued surveillance of colistin resistance in clinical settings, farm animals, and related products is necessary.…”
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    Carriage and Transmission of mcr-1 in Salmonella Typhimurium and Its Monophasic 1,4,[5],12:i:- Variants from Diarrheal Outpatients: a 10-Year Genomic Epidemiology in Guangdong, Southern China
  10. 120830
    “…BACKGROUND: Antiangiogenic drug (AAD)-triggered oxygen and nutrient depletion through suppression of angiogenesis switches glucose-dependent to lipid-dependent metabolism. Blocking fatty acid oxidation can enhance AAD-mediated anti-tumor effects in colorectal cancer (CRC). …”
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    Impact of genetic variants involved in the lipid metabolism pathway on progression free survival in patients receiving bevacizumab-based chemotherapy in metastatic colorectal cancer: a retrospective analysis of FIRE-3 and MAVERICC trials
  11. 120831
    “…Immunohistochemical analysis was performed at the Pathology Division, University Hospital of Cagliari on 3 μm thick sections obtained from paraffin blocks. The intensity of immunohistochemical staining was subclassified into four groups: score 0 if negative or weak membrane staining in less than 10% of tumor cells; score 1+ if weak membrane staining in at least 10% of tumor cells or moderate membrane staining in less than 10% of tumor cells; score 2+ if moderate membrane staining in at least 10% of tumor cells or intensive membrane staining in less than 10% of tumor cells; score 3+ if intense membrane staining in at least 10% of tumor cells. …”
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    New Horizons in Metastatic Colorectal Cancer: Prognostic Role of CD44 Expression
  12. 120832
    por Lucena Perico, L, MacNaughton, W K
    Publicado 2023
    “…When we investigated the mechanisms of action, the Src tyrosine kinase inhibitor, PP2, blocked PAR2-induced wound healing (p<0.0001). PAR2 activation increased Src phosphorylation (Y416, p<0.05) and the immunofluorescence showed a rise in actin cable formation at the wound edge and a reduction in lamellipodia/filopodia formation in the group treated with PP2 when compared to 2fLI (p<0.001). …”
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    A6 PROTEASE-ACTIVATED RECEPTOR (PAR)-2 ACTIVATION ENHANCES EPITHELIAL WOUND HEALING MIGRATION THROUGH SRC AND RAC1 PATHWAYS
  13. 120833
    “…In this study, to construct a stable and high-yield 9-OHAD producer, we investigated a combined strategy of blocking Δ(1)‑dehydrogenation and regulating metabolic flux. …”
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    Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ(1)-dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum
  14. 120834
    por Orlow, Irene, Sadeghi, Keimya D., Edmiston, Sharon N., Kenney, Jessica M., Lezcano, Cecilia, Wilmott, James S., Cust, Anne E., Scolyer, Richard A., Mann, Graham J., Lee, Tim K., Burke, Hazel, Jakrot, Valerie, Shang, Ping, Ferguson, Peter M., Boyce, Tawny W., Ko, Jennifer S., Ngo, Peter, Funchain, Pauline, Rees, Judy R., O’Connell, Kelli, Hao, Honglin, Parrish, Eloise, Conway, Kathleen, Googe, Paul B., Ollila, David W., Moschos, Stergios J., Hernando, Eva, Hanniford, Douglas, Argibay, Diana, Amos, Christopher I., Lee, Jeffrey E., Osman, Iman, Luo, Li, Kuan, Pei-Fen, Aurora, Arshi, Gould Rothberg, Bonnie E., Bosenberg, Marcus W., Gerstenblith, Meg R., Thompson, Cheryl, Bogner, Paul N., Gorlov, Ivan P., Holmen, Sheri L., Brunsgaard, Elise K., Saenger, Yvonne M., Shen, Ronglai, Seshan, Venkatraman, Nagore, Eduardo, Ernstoff, Marc S., Busam, Klaus J., Begg, Colin B., Thomas, Nancy E., Berwick, Marianne
    Publicado 2023
    “…Age of the FFPE tissue blocks (p<0.001) and time elapsed from sectioning to co-extraction (p = 0.002) were associated with methylation screening failures. …”
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    InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma
  15. 120835
    “…HSP60-siRNA transfection blocked the effect of ATF5 on HK-2 cells exposed to continuous HG treatment. …”
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    ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response
  16. 120836
    “…PD-L1 (programmed death-ligand-1) expression was increased in CR cells; therefore, we assessed dual inhibition + PD1 (programmed cell death protein-1) blocking and report profound anti-tumor growth and improved immunity in CR tumors which in turn extended overall survival in mice. …”
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    Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer
  17. 120837
    “…METHODS: Formalin-fixed, paraffin-embedded (FFPE) tissue blocks of NG, HT, and FA were included in the study. …”
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    A study to evaluate association of nuclear grooving in benign thyroid lesions with RET/PTC1 and RET/PTC3 gene translocation
  18. 120838
    “…Maintenance of glucose tolerance required Rela but was independent of classical NF-κB inflammatory cascades, as blocking NF-κB signalling in vivo by beta cell knockout of Ikbkg (NEMO), or beta cell overexpression of Tnfaip3 (A20), did not cause severe glucose intolerance. …”
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    RELA governs a network of islet-specific metabolic genes necessary for beta cell function
  19. 120839
    “…RESULTS: CD73/NT5E is induced by the EGF/EGFR-EMT-axis and blocked by Cetuximab and MEK inhibitor. Inhibition of CD73 with the novel antagonizing antibody 22E6 specifically repressed EGFR-dependent migration and invasion of HNSCC cells in 2D. …”
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    5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
  20. 120840
    “…CONCLUSION: Inclined angles of the quadrilateral plate could be used to assess the quality of fracture reduction and provide a basis for evaluating the rotational displacement of fracture blocks in the quadrilateral plate, which compensates the shortage of classic Matta criteria.…”
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    Inclined angles of acetabular quadrilateral plate: digital measurement and clinical application of the new anatomical concept
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