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  1. 120861
    “…Additional studies showed that depletion of macrophages blocked the therapeutic effects of hUC-EVs-ATO on aGVHD. …”
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    hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
  2. 120862
    “…CONCLUSIONS: Results from this birth cohort study proved that the pregnant women with the following SNPs such as Fads3 rs174455 T, Fads3 rs174464 A and Fads1 rs174448 G alleles should pay more attention on their exogenous DHA supplementation from the early and middle pregnancy for the blocked endogenous synthesis. Trial registration: This study was approved by the Ethics Committee of Beijing Pediatric Research Institution, Beijing Children’s Hospital affiliated to Capital Medical University (2016–08), which was also registered at the website of http://www.chictr.org.cn/showproj.aspx?…”
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    Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study
  3. 120863
    “…The study might expand new ideas for blocking the secondary infection of E. granulosus PSCs via EVs miRNAs. …”
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    Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation
  4. 120864
    “…The uptake of α-Syn PFFs was also inhibited in LRP1-KO iPSNs, albeit to a much lesser extent compared to α-Syn monomers and oligomers. The blocking of lysine residues on α-Syn effectively decreased the uptake of α-Syn in iPSNs and the N-terminus of α-Syn was critical for LRP1-mediated α-Syn uptake. …”
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    LRP1 is a neuronal receptor for α-synuclein uptake and spread
  5. 120865
    “…Randomisation was stratified by site and age (65 years or ≥65 years), and within each stratum, blocks were of random sizes of two, four, or six patients. …”
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    Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
  6. 120866
    “…On the other hand, FHL2 overexpression in MIN6 cells blocked GSIS, increased the formation of reactive oxygen species and increased c-Jun activity. …”
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    Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes
  7. 120867
    “…BACKGROUND AND OBJECTIVE: Brensocatib is an investigational, first-in-class, selective, and reversible dipeptidyl peptidase 1 inhibitor that blocks activation of neutrophil serine proteases (NSPs). …”
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    Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis
  8. 120868
    por Kawabe, Yoshinori, Schaap, Pauline
    Publicado 2022
    “…However, deletion of cAMP receptors (cARs) or extracellular phosphodiesterase (PdsA) in Polyspondylium pallidum (Ppal, group 2) blocks fruiting body formation, suggesting that cAMP oscillations ancestrally control post-aggregative morphogenesis. …”
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    Adenylate cyclase A amplification and functional diversification during Polyspondylium pallidum development
  9. 120869
    “…Activity of the SCD1 promoter that was induced by T09 was blocked when the SRE mutation was introduced. CONCLUSION: The current study provides evidence of a physiological link between the LXRB and SREBP1 in the ruminant mammary cell. …”
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    The LXRB-SREBP1 network regulates lipogenic homeostasis by controlling the synthesis of polyunsaturated fatty acids in goat mammary epithelial cells
  10. 120870
    “…RESULTS: EMD 281014 (0.001–0.05 mg/kg) or MA (0.1–5 mg/kg) blocked d-fenfluramine-induced HTR dose-dependently during ageing. …”
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    Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex
  11. 120871
    por Bremer, Richard
    Publicado 2008
    “…Containing about 20 silicon modu les and related readout electronics, petals are the basic building blocks of the end cap system. Th e reception test mainly confirmed the very good quality of petals delivered by external intitu tes and found a small number of defects which could be repaired before integration of the petals int o the end cap. …”
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    Integration of the End Cap TEC+ of the CMS Silicon Strip Tracker
  12. 120872
    por Stoerig, Kathrin
    Publicado 2013
    “…Some of the most interesting questions mankind might ask are closely related to the field of astro- and particle physics: What are the fundamental building blocks of our universe and how do they interact? Will there eventually be a theory that can describe everything? …”
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    QCD background estimation for Supersymmetry searches with jets and missing transverse momentum with the ATLAS experiment at the Large Hadron Collider
  13. 120873
    por Betz, Michael
    Publicado 2014
    “…This provides photons, which can convert into hypothetical Axion Like Particles or other WISPs. The photons are blocked by a wall but the WISPs practically do not interact with matter and can hence propagate to the ``detection region''. …”
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    The CERN Resonant Weakly Interacting Sub-eV Particle Search (CROWS)
  14. 120874
    por Jebramcik, Marc Andre
    Publicado 2020
    “…This thesis discusses important questions of the beam dynamics in the proton-lead operation in the Large Hadron Collider (LHC) at CERN in Geneva. In two time blocks of several weeks in the years 2013 and 2016, proton-lead collisions have so far been successfully generated in the LHC and used by the experiments at the LHC. …”
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    Beam Dynamics of Proton-Nucleus Collisions in the Large Hadron Collider
  15. 120875
    “…Thus, we hypothesize that GIP blocks the formation of the GllA1/GllA2 complex by interacting with GllA1 or GllA2. …”
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    Gallocin A, an Atypical Two-Peptide Bacteriocin with Intramolecular Disulfide Bonds Required for Activity
  16. 120876
    por Hernández-Bernal, Francisco, Ricardo-Cobas, Maria C., Martín-Bauta, Yenima, Rodríguez-Martínez, Ernesto, Urrutia-Pérez, Klaudia, Urrutia-Pérez, Karen, Quintana-Guerra, Joel, Navarro-Rodríguez, Zadis, Piñera-Martínez, Marjoris, Rodríguez-Reinoso, José L., Chávez-Chong, Cristina O., Baladrón-Castrillo, Idania, Melo-Suárez, Grettel, Batista-Izquierdo, Alejandro, Pupo-Micó, Alexis, Mora-Betancourt, Ricardo, Bizet-Almeida, Jacqueline, Martínez-Rodríguez, Maria C., Lobaina-Lambert, Leonardo, Velázquez-Pérez, Vivian M., Soler-Díaz, Jalimy, Laurencio-Vallina, Sandra, Meriño-Hechavarría, Tamara, Carmenaty-Campos, Norberto, Rodríguez-Montero, Enri, Limonta-Fernández, Miladys, Alonso-Valdés, Marel, Hernández-Rodríguez, Reinier, Pimentel-Vázquez, Eulogio, Catasús-Álvarez, Karem M., Cabrera-Núñez, Maria V., Ayala-Ávila, Marta, Muzio-González, Verena L.
    Publicado 2023
    “…Subjects were randomly assigned (1:1, in blocks) to two groups: placebo, and 50 μg RBD vaccine (Abdala). …”
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    A phase 3, randomised, double-blind, placebo-controlled clinical trial evaluation of the efficacy and safety of a SARS-CoV-2 recombinant spike RBD protein vaccine in adults (ABDALA-3 study)
  17. 120877
    “…Treatment of nucleus pulposus cells with VDR reduction using 1,25(OH)(2)D(3) or resveratrol partially rescued the degeneration phenotypes, by up-regulating Sirt1 expression and inhibiting NF-κB inflammatory pathway; these effects in nucleus pulposus cells were blocked by inhibition of Sirt1. CONCLUSION: Results from this study indicate that the 1,25(OH)(2)D/VDR pathway can prevent the degeneration of nucleus pulposus cells by inhibiting the NF-κB inflammatory pathway mediated by Sirt1. …”
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    Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway
  18. 120878
    “…First, vinyl covalent organic framework (Vinyl COF) was synthesized at room temperature using 1,4-diradical-2,5-divinylbenzene (Dva) and 1,3,5-tris(4-aminophenyl)benzene (Tab) as building blocks. Then, thioether-bridged aromatic amine-functionalized spherical COF-NH(2) was synthesized through a thiol-alkenyl click reaction using 4-aminothiophenol as the functional monomer. …”
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    球形氨基功能化共价有机骨架化合物的制备及对全氟化合物的吸附性能考察
  19. 120879
    “…BACKGROUND: Vedolizumab blocks inflammatory activity within the gastrointestinal tract. …”
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    Vedolizumab for induction and maintenance of remission in Crohn's disease
  20. 120880
    “…A novel extended EQ-VT design was created that included 18 blocks of 10 health states, comprising 150 unique health states and 135 observations per health state. …”
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    Evaluation of EuroQol Valuation Technology (EQ-VT) Designs to Generate National Value Sets: Learnings from the Development of an EQ-5D Value Set for India Using an Extended Design (DEVINE) Study
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