“…BACKGROUND: Soluble suppression of tumorigenicity 2 (sST2), a member of the interleukin-1 receptor family, binds IL-33, preventing its interaction with membrane-bound form ST2 (ST2L), thereby blocking its protection against atherosclerosis. High-density lipoprotein cholesterol (HDL-C), a variety of lipoproteins with mean size of 8–10 nm and density of 1.063–1.21 g/mL, not only acts as lipid transporters that transport cholesterol reversely, but also carries a variety of proteins and microRNAs endowing it with the ability to prevent cardiovascular disease. …”
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“…CONCLUSIONS: For members newly initiating single-agent angiotensin system blocking medication, the amount of prescription cost-sharing was associated with a negative impact on refill persistence.…”
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“…Adenosine has immune suppressive effects on the TME through the A2 adenosine receptor (A2AR) including decreased T cell activation and proliferation (Ohta et al., 2009). Blocking A2AR on tumor associated myeloid cells such as macrophages, dendritic cells, and myeloid derived suppressor cells in preclinical mouse models have shown enhanced tumor killing (Cekic et al 2014). …”
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“…To explore treatments, we tested a drug called SPIKENET (SPK), a 15-amino acid synthetic peptide, that blocks the virus from attaching and entering cells. …”
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“…In Exp II, 200 sows were randomly blocked, factorial 2 × 2 (without or with Vit 1,25-(OH)(2)D(3) and without or with CAP): T1—control (without Vit 1,25-(OH)(2)D(3) and CAP); T2—3.5 µg Vit 1,25-(OH)(2)D(3)/Gest/day and 7.0 µg Vit 1,25-(OH)(2)D(3)/Lact/day; T3—7.0 µg CAP/Gest/day and 14.0 µg CAP/Lact/day; T4—3.5 µg Vit 1,25-(OH)(2)D(3) + 7 µg CAP/Gest/day; and 7.0 µg Vit 1,25-(OH)(2)D(3) + 14.0 µg CAP/Lact/day. …”
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“…Use of Spironolactone unmasked natriuresis by blocking aldosterone activity on the intercalated cells of the renal nephron. …”
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“…Presence of a neutralizing or blocking antibody against the TSH receptor(1) or a false positive TSI have been implicated in such rare cases. …”
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“…The ligand-activated androgen receptor (AR) is a transcription factor that drives prostate cancer (CaP). Blocking androgen-activation of AR via androgen deprivation therapy (ADT) is the default treatment for metastatic CaP. …”
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“…In addition, none of the current treatments for Graves’ hyperthyroidism are effective in treating TED and, in some cases, such as with RAI, worsen the condition. Blocking TSHR activation directly via a TSHR antagonist may provide an important new therapeutic mechanism to treat patients with Graves’ disease that would effectively treat both the hyperthyroidism and TED. …”
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“…Furthermore, treating ovariectomized mice with FSH-blocking polyclonal antibodies results in increased bone mineral density. …”
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“…Whereas ghrelin activates GHSR, LEAP2 blocks ghrelin from activating GHSR and also inhibits GHSR constitutive activity. …”
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“…Both SNPs are in the first intron of SLC7A2 but appear to exert opposite effect on HbA1c and associated with distinct haplotype blocks. ATAC-Seq analyses of human islets show that these SNPs are within 1 kb of binding sites for MAFB and FOXA2 transcription factors, both critical for α cell gene expression. …”
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“…Checkpoint inhibitors increase immune activation by blocking natural regulatory molecules on T cells, including programmed death protein (PD1) and cytotoxic T lymphocyte antigen (CTLA4). …”
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“…CONCLUSIONS: This is the first study to determine the prevalence of gametocytes among patients with symptomatic P. falciparum malaria, identify the risk factors for gametocyte carriage, and potential gametocyte carriers in Thailand. Blocking transmission is one of the key strategies for eliminating malaria in these areas. …”
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“…For example, targeting the UPR pathway by blocking excessive autophagy or inducing moderate UPR could potentially reduce tissue injury and promote cell survival after ischemic stroke. …”
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“…Speaking quantitatively, one unit of the syphilitic antibodies plus antigen will fix 0.1 cubic centimeter of guinea pig complement, but this unit can also be saturated and blocked by nearly the same amount of the seemingly indifferent serum component of the serum to be tested. …”
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“…METHODS: We chose the three most-used classes of cardiovascular drugs for this investigation: beta blocking agents, calcium channel blockers mainly with vascular effects, and plain ACE inhibitors. …”
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“…Finally, several recent small molecules of interest as potential drugs have been shown to act by blocking protein-protein interactions based on intrinsic disorder of one of the partners. …”
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“…MiR-199b-5p over-expression blocks expression of several cancer stem-cell genes, impairs the engrafting potential of MB cells in the cerebellum of athymic/nude mice, and of particular interest, decreases the MB stem-cell-like (CD133+) subpopulation of cells. …”
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“…Treatments were randomised in equal numbers within blocks of 50 and allocation was in sealed envelopes. …”
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