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  1. 120961
    “…Late samples were bundled into 7 d blocks (POD 7-13, 14-20, etc.) and treated as single time points. …”
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    Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases
  2. 120962
    “…A total of 16 scenarios were generated by using D-Efficient design and were randomly divided into 2 blocks. Eligible patients were recruited and interviewed from outpatient and inpatient settings of 2 public hospitals in Beijing and Shenzhen, respectively. …”
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    Importance of attributes and willingness to pay for oral anticoagulant therapy in patients with atrial fibrillation in China: A discrete choice experiment
  3. 120963
    “…ERK inhibitors also significantly blocked the effects of hypoxic/reoxygenation on the protein expression of M1-related pro-inflammatory factors TNF-α, CD80 and M2-related anti-inflammatory factors ARG-1 and CD206. …”
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    C-X3-C motif chemokine ligand 1/receptor 1 regulates the M1 polarization and chemotaxis of macrophages after hypoxia/reoxygenation injury
  4. 120964
    “…Maraviroc induced Aβ transendothelial transport, which was blocked by LRP1 antagonist but not RAGE antagonist. …”
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    CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice
  5. 120965
    “…INTERPRETATION: These data support the use of single low-dose primaquine as an effective supplement to dihydroartemisinin–piperaquine and pyronaridine–artesunate for blocking P falciparum transmission. The new pyronaridine–artesunate plus single low-dose primaquine combination is of immediate relevance to regions in which the containment of partial artemisinin and partner-drug resistance is a growing concern and in regions aiming to eliminate malaria. …”
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    Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial
  6. 120966
    “…In vivo embryo quantity and quality (total structures, morulae, blastocysts, viable, degenerated and blocked embryos) were recorded in each SOV protocol. …”
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    Effects of Extra-Long-Acting Recombinant Bovine FSH (bscrFSH) on Cattle Superovulation
  7. 120967
    “…Patients were randomly allocated (1:1 in blocks of eight to 12) to either artemether–lumefantrine alone (dosed according to WHO guidelines) or artemether–lumefantrine plus amodiaquine (10 mg base per kg/day), both given orally as six doses over 3 days. …”
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    Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial
  8. 120968
    “…AIMS/HYPOTHESIS: Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have improved the treatment of a broad spectrum of cancers. …”
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    Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade
  9. 120969
    por Soulsby, William Daniel
    Publicado 2022
    “…The ADVOCATE trial was a phase III randomized double‐blind placebo‐controlled clinical trial to investigate whether avacopan, a C5a receptor inhibitor involved in blocking complement activation, could replace steroids in induction therapy for AAV in addition to standard‐of‐care therapy via a noninferiority trial design. …”
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    Journal Club Review of “Avacopan for the Treatment of ANCA‐Associated Vasculitis”
  10. 120970
    “…Methods: A prospective, observational, multicenter study was undertaken in nine EDs, between July 2016 and August 2017. Blocks of ten consecutive adult patients presenting at pre-specified times were identified. …”
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    Development of Screening Tools to Predict Medication-Related Problems Across the Continuum of Emergency Department Care: A Prospective, Multicenter Study
  11. 120971
    “…After the intervention of hsa-miR-28-5p mimic + doxorubicin on DLBCL cells, the cell cycle was arrested in the S-phase and DNA synthesis was blocked. hsa-miR-28-5p mimic + doxorubicin could regulate the cycle of DLBCL cells. …”
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    Effects of hsa-miR-28-5p on Adriamycin Sensitivity in Diffuse Large B-Cell Lymphoma
  12. 120972
    “…We therefore hypothesize that neutrophil count and neutrophil-to-lymphocyte ratio could serve as markers of therapeutic efficiency for IL-17A-blocking antibodies in the context of active inflammation.…”
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    Tocilizumab, netakimab, and baricitinib in patients with mild-to-moderate COVID-19: An observational study
  13. 120973
    “…Background: The occurrence and development of solid tumors depend on the blood supply in the tumor microenvironment (TME). Blocking angiogenesis is a new therapeutic strategy to inhibit tumor growth. …”
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    Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells
  14. 120974
    “…Conclusion: The processing of Cornus officinalis may improve the renal injury of DN rats by blocking the activation of Wnt/β-catenin signaling pathway, regulating the structural composition of intestinal microorganisms, and ultimately playing a role in renal protection.…”
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    Cornus officinalis prior and post-processing: Regulatory effects on intestinal flora of diabetic nephropathy rats
  15. 120975
    por Ho, Cheuk Wah
    Publicado 2022
    “…It is related to the concentration and the affinity of anti-thyroid stimulating antibodies and blocking antibodies. The outcome depends on which antibodies predominate. …”
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    ODP453 A Lady Changes from Hypothyroid to Hyperthyroid State during Pregnancy
  16. 120976
    “…JTV519, which stabilizes ryanodine receptors and blocks calcium uptake via SERCA [4], has been reported to have a strong cardioprotective effect via stabilization of ryanodine receptor 2. …”
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    PSUN311 JTV-519 Alleviates the Impairment of FGF21 Axis Signaling after Spinal Cord Contusion in Mice
  17. 120977
    “…The conversion of 11K-4AD to 11K-T was AKR1C3 dependent since a panel of AKR1C3 inhibitors blocked 11K-T formation. We found that 11K-T is deactivated to 11β-hydroxy-testosterone (11β-OH-T) and 11K-4AD can be back converted to 11β-OH-4AD by 11β-hydroxy steroid dehydrogenase type 1 (HSD11B1). …”
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    RF03 | PMON296 Insulin-induced AKR1C3 Metabolizes Classical and 11-oxygenated Androgens in a Model of PCOS Adipocytes
  18. 120978
    “…CONCLUSION: Within pituitary adenomas, the SSTR is a transcriptional target of Gli1, and this response is blocked by the activation of the GR. These data form the basis of combination therapy for CD with mifepristone and pasireotide. …”
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    RF01 | PMON168 Hedgehog-Induced Somatostatin Receptor Expression is Inhibited by the Activation of the Glucocorticoid Receptor Signaling Pathway in Human Pituitary Adenoma Organoids
  19. 120979
    “…We previously reported that OR-449, dosed orally at 30 mg/kg for 28 days, completely blocked the growth of SJ-ACC3, a pediatric ACC patient-derived tumor xenograft (PDX), in immunocompromised mice. …”
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    RF07 | PSUN355 Downstream Targets of the Steroidogenic Factor-1 (SF-1) Antagonist OR-449 in PDX Models of ACC
  20. 120980
    “…These results confirm the cephalosporins resistance urgency in the central Chinese poultry sector and suggest the continuous monitoring and timely detection of ESBL-producing isolates is vitally important in establishing appropriate antimicrobial therapies and blocking their transmission. ABSTRACT: The emergence and dissemination of Escherichia coli (E. coli) strains that produce extended-spectrum beta-lactamases (ESBLs) represents a major public health threat. …”
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    Prevalence of Extended-Spectrum β-Lactamase-Resistant Genes in Escherichia coli Isolates from Central China during 2016–2019
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