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“…Bone substitutes have been applied to treat osseous defects for a long time. …”
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“…Vanishing bone disease is a rare clinical entity with unknown etiology. …”
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“…Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. …”
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“…In all studies there was a benefit both in terms of bone mineral density and fracture risk.…”
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“…SIMPLE SUMMARY: Although rare, malignant bone sarcomas have devastating clinical implications for the health and survival of young adults and children. …”
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“…Bone apatite is not hydroxyapatite (HAp), it is carbonate apatite (CO(3)Ap), which contains 6–9 mass% carbonate in an apatitic structure. …”
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“…Recent data demonstrate the anabolic effect of oxytocin on bone. Bone cells express oxytocin receptors. Oxytocin promotes osteoblasts differentiation and function, leading to an increased bone formation with no effect on bone resorption and an improvement of bone microarchitecture. …”
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“…The following characteristics contribute to the OA scenario: penetrating resorption canals and local loss of ACC; cracking of ACC and SCB; sealing of cracks with High-Density Mineral Infill (HDMI); extrusion of HDMI into HAC to form High-Density Mineral Protrusions (HDMP) in HAC which may fragment and contribute to its destruction; SCB marrow space infilling and densification with (at first) woven bone; disruption, fibrillation and loss of HAC; eburnation; repair with abnormal tissues including fibrocartilage and woven bone; attachment of Sharpey fibres to SCB trabeculae and adipocyte-moulded extensions to trabeculae (excrescences). …”
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“…This will lead to the accumulation of sphingolipids in various organs, such as liver, spleen, bone marrow. Bone involvement is frequent in Gaucher patients, leading to bone pain, necrosis and even fractures or growth deficiency in children, with painful surgeries and progressively decreasing quality of life. …”
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“…Worldwide, there are millions of patients each year suffering from bone-related illness due to trauma, degenerative diseases, infections or oncology that require orthopaedic intervention involving bone grafts. …”
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“…PURPOSE OF REVIEW: For solid tumours such as breast and prostate cancer, and haematological malignancies such as myeloma, bone represents a supportive home, where the cellular crosstalk is known to underlie both tumour growth and survival, and the development of the associated bone disease. …”
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“…Emerging knowledge suggests an increasing importance of gut microbiota in health and disease. Allergy and bone metabolism are closely interconnected, and the possible negative effects of common therapies are not the only aspects of this relationship. …”
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“…Bone mineral mass, geometry and microstructure, hence determinants of fracture risk, result bone accrual during growth and bone loss later in life. …”
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