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801Publicado 1984“…We isolated cells from both calvaria and the outer cortices of long bones from 3- to 5-mo bovine fetuses. The cells were identified as functional osteoblasts by indirect immunofluorescence using antibodies against three bone-specific, noncollagenous matrix proteins (osteonectin, the bone proteoglycan, and the bone sialoprotein) and against type 1 collagen. …”
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802por Malaval, Luc, Wade-Guéye, Ndéyé Marième, Boudiffa, Maya, Fei, Jia, Zirngibl, Ralph, Chen, Frieda, Laroche, Norbert, Roux, Jean-Paul, Burt-Pichat, Brigitte, Duboeuf, François, Boivin, Georges, Jurdic, Pierre, Lafage-Proust, Marie-Hélène, Amédée, Joëlle, Vico, Laurence, Rossant, Janet, Aubin, Jane E.“…Bone sialoprotein (BSP) and osteopontin (OPN) are both highly expressed in bone, but their functional specificities are unknown. …”
Publicado 2008
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803“…As a result, it has become clinically desirable to augment mechanical fixation with biologic strategies in order to accelerate osteogenesis and promote successful arthrodesis. The discovery of bone morphogenic protein (BMP) has been pivotal in understanding the biology of fracture healing and has been a source of intense clinical research as an adjunct to fracture treatment. …”
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804
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805“…Immunohistochemically, the tumor expressed bone morphogenic protein 4, indicating a possible role of this protein in the new bone formation in schwannomas.…”
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806“…In addition, bisphosphonates maintain bone health during adjuvant therapy; this may be especially important for women who are at high risk for fracture.…”
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807por Thobe, Megan N., Clark, Robert J., Bainer, Russell O., Prasad, Sandip M., Rinker-Schaeffer, Carrie W.“…Bone is the most common site for metastasis in human prostate cancer patients. …”
Publicado 2011
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808“…Receptor activator of nuclear factor-κB ligand (RANKL) plays a pivotal role in regulating bone homeostasis. Osteoporosis and malignant bone disease secondary to breast cancer are characterized by enhanced RANKL production and increased bone turnover. …”
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809“…We therefore initiated this study of bone mass, bone turnover and prevalence of fractures in a large cohort of adult patients. …”
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810“…Non-enzymatic glycation (NEG) and enzymatic biochemical processes create crosslinks that modify the extracellular matrix (ECM) and affect the turnover of bone tissue. Because NEG affects turnover and turnover at the local level affects microarchitecture and formation and removal of microdamage, we hypothesized that NEG in cancellous bone is heterogeneous and accounts partly for the contribution of microarchitecture and microdamage on bone fragility. …”
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811por Gessmann, Jan, Köller, Manfred, Godry, Holger, Schildhauer, Thomas Armin, Seybold, Dominik“…Distraction osteogenesis after post-traumatic segmental bone loss of the tibia is a complex and time-consuming procedure that is often complicated due to prolonged consolidation or complete insufficiency of the regenerate. …”
Publicado 2012
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812por He, Qiang, Chen, Huiling, Huang, Li, Dong, Jingjing, Guo, Dagang, Mao, Mengmeng, Kong, Liang, Li, Yang, Wu, Zixiang, Lei, Wei“…BACKGROUND: Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. …”
Publicado 2012
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813“…PURPOSE: Bisphosphonates (BPs) are antiresorptive drugs that provide important effects on bone turnover. The key to the high efficiency of BPs is their affinity for bone tissue, and their chemical structure provides their molecular mechanism of action. …”
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814“…Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. …”
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815por Klein, Karina, Zamparo, Enrico, Kronen, Peter W, Kämpf, Katharina, Makara, Mariano, Steffen, Thomas, von Rechenberg, Brigitte“…BACKGROUND: Reproducible and suitable animal models are required for in vivo experiments to investigate new biodegradable and osteoinductive biomaterials for augmentation of bones at risk for osteoporotic fractures. Sheep have especially been used as a model for the human spine due to their size and similar bone metabolism. …”
Publicado 2013
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816“…Bone marrow is a highly heterogeneous and vascularized tissue. …”
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817“…A few studies in animals and a study in humans showed a positive effect of probiotic on bone metabolism and bone mass density. Most of the investigated bacteria were Lactobacillus and Bifidobacterium . …”
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818por Martin, T. John“…Bone is continuously remodelled at many sites asynchronously throughout the skeleton, with bone formation and resorption balanced at these sites to retain bone structure. …”
Publicado 2014
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819por Barbosa, Danillo, Villaverde, Antonio Guillermo Jose Balbin, LoschiavoArisawa, Emilia Ângela, de Souza, Renato Aparecido“…OBJECTIVE: To investigate, by digital radiology, the bone regeneration process in rats submitted to femoral osteotomy and treated with low power laser therapy. …”
Publicado 2014
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820por Hakimi, Mohssen, Grassmann, Jan-Peter, Betsch, Marcel, Schneppendahl, Johannes, Gehrmann, Sebastian, Hakimi, Ahmad-Reza, Kröpil, Patric, Sager, Martin, Herten, Monika, Wild, Michael, Windolf, Joachim, Jungbluth, Pascal“…One possible alternative to the application of autologous bone grafts represents the use of autologous bone marrow concentrate (BMC). …”
Publicado 2014
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