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149841por Wang, Chao, Dong, Keqin, Wang, Yuning, Peng, Guang, Song, Xu, Yu, Yongwei, Shen, Pei, Cui, Xingang“…Moreover, lower HECW1 expression was found in ccRCC patients with a higher tumor node metastasis (TNM) stage, bone metastasis, or first-line targeted drug resistance (p < 0.001). …”
Publicado 2021
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149842por Kowalski, Emily S., Khairnar, Rahul, Gryaznov, Anton A., Kesari, Vivek, Koroulakis, Antony, Raghavan, Prashant, Chen, Wengen, Woodworth, Graeme, Mishra, Mark“…BACKGROUND AND PURPOSE: Meningiomas express the somatostatin receptor (SSTR), which normal bone and brain lack. PET imaging with SSTR ligands such as (68) Ga-DOTATATE have been recently shown to aid in the imaging and identification of menginiomas. …”
Publicado 2021
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149843“…However, histopathological UIP or probable UIP patterns were found in 63.6% of patients. Age at bone marrow failure (BMF) and the frequency of normal to mild thrombocytopenia in later-onset patients was significantly higher than in early-onset patients (p = 0.017 and p = 0.021, respectively). …”
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149844por Drozdz, Maciej, Frazão, João, Silva, Fatima, Das, Partha, Kleophas, Werner, Al Badr, Wisam, Brzosko, Szymon, Jacobson, Stefan H.“…This study focuses on improvements in six aspects of quality of dialysis care (adequacy, anemia, nutrition, chronic kidney disease-mineral bone disorder (CKD-MBD), blood pressure and vascular access) aligning with KDIGO guidelines, during the first 6 months of hemodialysis. …”
Publicado 2021
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149845por Suryawanshi, Gajendra W., Arokium, Hubert, Kim, Sanggu, Khamaikawin, Wannisa, Lin, Samantha, Shimizu, Saki, Chupradit, Koollawat, Lee, YooJin, Xie, Yiming, Guan, Xin, Suryawanshi, Vasantika, Presson, Angela P., An, Dong-Sung, Chen, Irvin S. Y.“…Using a new clonal tracking methodology designed for small sample volumes, we aim to reveal the underlying clonal dynamics of human cell repopulation in a mouse environment. METHODS: Humanized bone marrow-liver-thymus (hu-BLT) mice were generated by transplanting lentiviral vector-transduced human fetal liver HSPC (FL-HSPC) in NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ (NSG) mice implanted with a piece of human fetal thymus. …”
Publicado 2021
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149846por Zhan, Fangbiao, He, Tao, Chen, Zhiyu, Zuo, Qiang, Wang, Yang, Li, Qiaochu, Zhong, Shenxi, Ou, Yunsheng“…BACKGROUND: Osteosarcoma (OS) is the most prevalent primary bone malignancy affecting adolescents, yet the emergence of chemoradiotherapeutic resistance has limited efforts to cure affected patients to date. …”
Publicado 2021
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149847por Aleahmad, Mehdi, Bozorgmehr, Mahmood, Nikoo, Shohreh, Ghanavatinejad, Alireza, Shokri, Mohammad-Reza, Montazeri, Samaneh, Shokri, Fazel, Zarnani, Amir-Hassan“…METHODS: MenSCs were collected from 18 apparently healthy women and characterized. Bone marrow mesenchymal stem cells (BMSCs) served as a control. …”
Publicado 2021
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149848“…The rate of AYUSH practitioner utilization was determined by older age (≥60 years) (Adjusted Odds Ratio-AOR: 1.20, 95% Confidence Interval-CI: 1.07–1.34), having pain (AOR: 1.48, 95% CI: 1.29–1.69), any bone or joint diseases (AOR: 1.57, 95% CI: 1.35–1.82), current tobacco use (AOR: 1.30, 95% CI: 1.12–1.50), male sex (AOR: 0.76, 95% CI: 0.68–0.85), high subjective socioeconomic status (AOR: 0.72, 95% CI: 0.60–0.87), urban residence (AOR: 0.71, 95% CI: 0.57–0.88), diabetes (AOR: 0.66, 95% CI: 0.55–0.81), chronic heart disease (AOR: 0.52, 95% CI: 0.37–0.73), and having a health insurance cover (AOR: 0.36, 95% CI: 0.30–0.44). …”
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149849por Niparuck, Pimjai, Police, Pornnapa, Noikongdee, Phichchapha, Siriputtanapong, Kanchana, Limsuwanachot, Nittaya, Rerkamnuaychoke, Budsaba, Chuncharunee, Suporn, Siriboonpiputtana, Teerapong“…METHODS: Patients with newly diagnosed AML and MDS-EB were recruited, extraction of deoxyribonucleic acid from bone marrow samples were done and then performing TP53 mutation analysis, using MassArray® System (Agena Bioscience, CA, USA). …”
Publicado 2021
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149850por van de Donk, Pim P., Wind, Thijs T., Hooiveld-Noeken, Jahlisa S., van der Veen, Elly L., Glaudemans, Andor W. J. M., Diepstra, Arjan, Jalving, Mathilde, de Vries, Elisabeth G. E., de Vries, Erik F. J., Hospers, Geke A. P.“…In lymphoid tissues, uptake was highest in spleen (10.9, IQR: 8.8–12.4) and bone marrow (2.5, IQR: 2.1–3.0). SUV(max) in tumor lesions (n = 41) at baseline was 1.9 (IQR: 1.7–2.3). …”
Publicado 2021
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149851por Zaremba, Anne, Kramer, Rafaela, De Temple, Viola, Bertram, Stefanie, Salzmann, Martin, Gesierich, Anja, Reinhardt, Lydia, Baroudjian, Barouyr, Sachse, Michael M., Mechtersheimer, Gunhild, Johnson, Douglas B., Weppler, Alison M., Spain, Lavinia, Loquai, Carmen, Dudda, Milena, Pföhler, Claudia, Hepner, Adriana, Long, Georgina V., Menzies, Alexander M., Carlino, Matteo S., Lebbé, Céleste, Enokida, Tomohiro, Tahara, Makoto, Bröckelmann, Paul J., Eigentler, Thomas, Kähler, Katharina C., Gutzmer, Ralf, Berking, Carola, Ugurel, Selma, Stadtler, Nadine, Sucker, Antje, Becker, Jürgen C., Livingstone, Elisabeth, Meier, Friedegund, Hassel, Jessica C., Schadendorf, Dirk, Hanoun, Maher, Heinzerling, Lucie, Zimmer, Lisa“…Some of these patients received metamizole in addition to ICI (ICI+/met+). Bone marrow biopsies (BMB) of these patients were compared to BMB from non-ICI treated patients with metamizole-induced grade 4 neutropenia (ICI-/met+). …”
Publicado 2021
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149852por Medrano-Trochez, Camila, Chatterjee, Paramita, Pradhan, Pallab, Stevens, Hazel Y., Ogle, Molly E., Botchwey, Edward A., Kurtzberg, Joanne, Yeago, Carolyn, Gibson, Greg, Roy, Krishnendu“…METHODS: 13 hMSC samples derived from 10 “healthy” donors were used to assess donor variability and tissue-of-origin differences in single-cell gene expression profiles. hMSCs derived and expanded from the bone marrow (BM) or cord tissue (CT) underwent controlled-rate freezing for 24 h. …”
Publicado 2021
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149853por Kamm, J. Lacy, Riley, Christopher B., Parlane, Natalie A., Gee, Erica K., McIlwraith, C. Wayne“…BACKGROUND: Mesenchymal stromal cells (MSCs) are believed to be hypoimmunogeneic with potential use for allogeneic administration. METHODS: Bone marrow was harvested from Connemara (n = 1), Standardbred (n = 6), and Thoroughbred (n = 3) horses. …”
Publicado 2021
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149854“…X-ray and micro-computerized tomography (μCT) scans were used to assess knee joint conditions and microstructure of subchondral bone. RESULTS: IRAK4 expression levels in synovial tissues of the OA model group exhibited a significant upward trend. …”
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149855por Kim, Jinsup, Kim, Min-Sun, Suh, Byung-Kyu, Ko, Cheol Woo, Lee, Kee-Hyoung, Yoo, Han-Wook, Shin, Choong Ho, Hwang, Jin Soon, Kim, Ho-Seong, Chung, Woo Yeong, Kim, Chan Jong, Han, Heon-Seok, Jin, Dong-Kyu“…The change of skeletal maturity defined as change in bone age/change in chronological age between the two groups was not significantly different (1.25 ± 0.58 for the DA-3002 group and 1.47 ± 0.45 for the comparator group, p = 0.134). …”
Publicado 2021
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149856Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunitypor Prado, Carolina, Osorio-Barrios, Francisco, Falcón, Paulina, Espinoza, Alexandra, Saez, Juan José, Yuseff, María Isabel, Pacheco, Rodrigo“…METHODS: Mice harbouring Drd3-deficient or Drd3-sufficient B cells were generated by bone marrow transplantation into recipient mice devoid of B cells. …”
Publicado 2021
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149857por Wang, Zhiming, He, Jin, Bach, Duc-hiep, Huang, Yung-hsing, Li, Zongwei, Liu, Huan, Lin, Pei, Yang, Jing“…METHODS: Adipocytes were either isolated from bone marrow aspirates of healthy donors or MM patients or derived from mesenchymal stem cells. …”
Publicado 2022
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149858VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathypor Cheng, Cheng, Weiss, Lan, Leinonen, Henri, Shmara, Alyaa, Yin, Hong Z., Ton, Timothy, Do, Annie, Lee, Jonathan, Ta, Lac, Mohanty, Eshanee, Vargas, Jesse, Weiss, John, Palczewski, Krzysztof, Kimonis, Virginia“…BACKGROUND: Pathogenic gain of function variants in Valosin-containing protein (VCP) cause a unique disease characterized by inclusion body myopathy with early-onset Paget disease of bone and frontotemporal dementia (also known as Multisystem proteinopathy (MSP)). …”
Publicado 2022
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149859por Ratter, Julia, Pellekooren, Sylvia, Wiertsema, Suzanne, van Dongen, Johanna M., Geleijn, Edwin, de Groot, Vincent, Bloemers, Frank W., Jansma, Elise, Ostelo, Raymond W. J. G.“…PLAIN ENGLISH SUMMARY: Bone fractures of the lower extremities are a common injury. …”
Publicado 2022
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149860por Oudaert, Inge, Satilmis, Hatice, Vlummens, Philip, De Brouwer, Wouter, Maes, Anke, Hose, Dirk, De Bruyne, Elke, Ghesquière, Bart, Vanderkerken, Karin, De Veirman, Kim, Menu, Eline“…Metabolic changes, induced by the hypoxic bone marrow, contribute to both MM cell survival and drug resistance. …”
Publicado 2022
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