“…This suggested that the additional bioactivity was likely in tissues not related to endochondral bone formation. In the phase III study, following subcutaneous administration at the recommended dose of 15 μg/kg to patients with achondroplasia aged 5–18 years, vosoritide was rapidly absorbed with a median time to maximal plasma concentration (C(max)) of 15 minutes, and cleared with a mean half-life of 27.9 minutes after 52 weeks of treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: During revision total knee arthroplasty (TKA), knee joint line restoration may be difficult due to bone loss or structural changes. Although bony landmarks are consistent and can be used as references, there are limited data in Asian patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mechanistically, we found a reduced RNA expression of CC chemokine ligand 2 (CCL-2), C-X-C motif chemokine-1 (CXCL-1), C-X-C motif chemokine-2 (CXCL-2), Interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) as well as a decreased nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)-inflammasome priming in atherosclerotic plaques from P2X(4)-deficient mice. Moreover, bone marrow derived macrophages isolated from P2X(4)-deficient mice revealed a reduced ATP-mediated release of CCL-2, CC chemokine ligand 5 (CCL-5), Interleukin-1β (IL-1β) and IL-6. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After DFSCs-sEVs transplantation, new periodontal ligament-like structures and bone formation were observed in the damaged periodontal area in rats. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TAb2 tumor cells drastically expanded F4/80(+) TAMs from bone marrow precursors, requiring CSF1 and VEGF. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Patients with pulmonary arterial hypertension (PAH) carrying bone morphogenetic protein receptor type 2 (Bmpr2) mutations present earlier with severe hemodynamic compromise and have poorer survival outcomes than those without mutation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among them, a paradoxical coexistence of a favorable predictive effect coupled with an unfavorable prognostic effect was observed in metastases to adrenal glands, brain, and liver (category I organs), whereas metastases to bone, pleura, pleural effusion, and mediastinum yielded consistent unfavorable predictive and prognostic effects (category II organs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on the percentage of CD34(+)VEGFR2 (CD309)(+) endothelial cells (ECs) in bone marrow (BM) detected by flow cytometry at 14 days before conditioning, patients aged 15 to 60 years with acute leukemia undergoing haploidentical HSCT were categorized as low-risk (EC ≥ 0.1%) or high-risk (EC < 0.1%); patients at high risk were randomly assigned (2:1) to receive NAC prophylaxis or nonprophylaxis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is the first time to design a novel mesh-like electrospun fiber loaded with atorvastatin (ATV) and investigated its effects on paracrine secretion by bone marrow-derived mesenchymal stem cells (BMSCs) and wound healing in vivo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We evaluated each participant’s height and body weight measurements, calf circumference, bone mass density, and results on the grip strength, single-leg standing, chair sit-and-reach, 8-ft up-and-go, 30-second chair stand, 2-minute step, 30-second arm curl, 6-m walk, and back scratch tests to determine their overall physical fitness, which consisted of their body composition, muscular strength and endurance, flexibility, and cardiopulmonary fitness. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our previous study showed that transplanted bone marrow-derived mesenchymal stem cells (BMSCs) play a “glia-like cells” role in initiating ENS regeneration in denervated mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Our software can effectively help medical students master first aid skills including hemostasis, cricothyroid membrane and bone marrow puncture, and its anatomy. This may also be used for soldiers and national first aid training. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the total operation time, preparation time of bone flap from the donor site, osteotomy time, and reconstruction time in the DS group were significantly lower than those in the traditional operation group (P < 0.05), but the shaping time and vascular anastomosis time of recipient area could not be shortened (P > 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…General data were collected from patients who met the criteria. The resected bone and soft tissues were collected and weighed precisely during TKA, and multivariate regression analysis was used to determine the factors affecting the weight of the removed knee tissues. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: MM cells were purified from bone marrow aspirates using CD138 microbeads and subjected to sequencing with a 387-gene Panel. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We collected mucosa, granulation, bone dust with mucosa or fluid from the middle ear or mastoid for the SARS-CoV-2 PCR tests during each otologic surgery. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Stem cell transduction and transplantation in syngeneic mice was used to assess the transforming ability of tnFGFR1 in bone marrow stem cells, and RPPA and RNA-Seq was used to examine the related signaling pathways and regulated target genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: A total of 5864 temporal bone computed tomography(CT) reports are labeled by two experienced radiologists as follows: (1) normal findings without notable lesions; (2) notable lesions but uncorrelated to tinnitus; and (3) at least one lesion considered as potential cause of tinnitus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Three phantoms were used: a soft-tissue tumour phantom, a bone-lung tumour phantom, and a resolution phantom. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso