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  1. 149921
    por Chitre, Mona M., Hayes, William
    Publicado 2008
    “…BACKGROUND: Accelerated bone loss is a well-known outcome of chronic treatment with glucocorticoids, making glucocorticoid-induced osteoporosis a significant cause of morbidity and a burden on health care resources. …”
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    3-Year Results of a Member and Physician Intervention to Reduce Risk Associated With Glucocorticoid-Induced Osteoporosis in a Health Plan
  2. 149922
    “…Recent data also suggest that TZDs may reduce bone density. Conversely, pioglitazone may have some vasculoprotective effect related to elevation of high-density lipoprotein and lessened progression of carotid intima-media thickness; however, anyeffect on macrovascular clinical outcomes is unknown. …”
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    Managing Type 2 Diabetes: Going Beyond Glycemic Control
  3. 149923
    “…The most common locations for the CT-guided biopsy were lung (18.2%), soft tissue (13.6%), kidney (9.1%), and bone (9.1%). The most common alterations were seen in PBRM1 (50%), VHL (43.9%), and SETD2 (35.7%) genes. …”
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    CT-based radiomics model for the prediction of genomic alterations in renal cell carcinoma (RCC)
  4. 149924
    “…SUMMARY BACKGROUND DATA: Metabolic and bariatric surgery has been implicated in significant bone loss and may increase fracture risk. Preoperative patient characteristics that might impact fracture risk and the time to fractures have not been established. …”
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    Rates, Risks, and Time to Fracture in Patients Undergoing Laparoscopic Vertical Sleeve Gastrectomy versus Roux-en-Y Gastric Bypass
  5. 149925
    Publicado 2023
    “…FUNDING: Bill & Melinda Gates Foundation, Institute of Bone and Joint Research, and Global Alliance for Musculoskeletal Health.…”
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    Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
  6. 149926
    “…No association was found with CS invasion, tumor size, bone erosion or dura invasion. We could not find any association between PD-L1 expression and recurrence. …”
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    PD-L1 Expression in Pituitary Neuroendocrine Tumors/Pituitary Adenomas
  7. 149927
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    SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
  8. 149928
    “…The expression of orexin receptors and the effects of orexins on adrenocortical steroidogenesis have been shown in experiments using adrenocortical cells. Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor (TGF)-β superfamily, also play functional roles in various endocrine tissues. …”
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    SAT269 Orexin Activates Adrenocortical Steroidogenesis With Upregulation Of BMP Signaling By Human H295R Cells
  9. 149929
    “…Stretched penile length was 7 cm (90(th) percentile), width was 3.2 cm. Results: Bone age was advanced to 10 year 0 months with height age of 7 year 3 months. …”
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    THU227 Isosexual Peudo-precocious Puberty Due To Leydig Cell Tumor In A Prepubertal Child
  10. 149930
    “…Mice without the Hsd11b1 gene (which encodes HSD-1) or given a HSD-1 inhibitor were protected from glucose intolerance, hyperinsulinemia, hepatic steatosis, adiposity, hypertension, myopathy, dermal atrophy, and trabecular bone loss associated with GC administration. The HSD-1 inhibitor AZD4017 prevented detrimental prednisolone effects on glycemic control and osteocalcin in a Phase 1 clinical trial. …”
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    SAT277 Intracellular Cortisol Control: An Approach To Reduce Cushing’s Syndrome Morbidity With Minimal Adrenal Insufficiency Risk?
  11. 149931
    “…Introduction: Heterozygous inactivating mutations in the maternal allele of the GNAS gene typically result in pseudohypoparathyroidism (PHP) characterized by developmental delay, short stature, obesity, hormone resistance and bone abnormalities. Recently, GNAS variants were also described in 1% of patients in the UK Genetics of Obesity cohort, resulting in reduced MC4R signalling. …”
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    THU143 A Novel Maternally Inherited GNAS Variant In A Family With Hyperphagia And Obesity
  12. 149932
    “…We found Blt2 gene expression in bone marrow derived macrophages and peritoneal macrophages, however we found little to no expression in pancreatic islets. …”
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    SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells
  13. 149933
    “…In recent years several authors have tried to investigate the markers that can predict the risk of bone fragility in this endocrine disorder. Two different isoforms of the GH receptor (GHR) have been described so far, which differ in the presence or absence of a transcript of exon 3 of the GHR gene. …”
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    THU050 The Role Of The GH Receptor Polymorphism As Prognostic Factor Of Vertebral Fractures In Acromegaly Patients Resistant To First Generation SSAs And Treated With GH Receptor Antagonist Or Second Generation Somatostatin Ligand
  14. 149934
    “…Laboratory investigations: HbA1c 11.9%, WBC 18-24x10(9)/L, Platelets 850-1,350x10(9)/L. Bone marrow examination was refused by the patient so the exact underlying hematological disorder could not be accurately diagnosed. …”
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    THU614 Neurofibromatosis Type 1 Presenting With Pheochromocytoma And Severe Vascular And Hematological Manifestations Due To A Novel NF1 Mutation
  15. 149935
    “…IGF-1 was low at 49 ng/mL (230 – 769 ng/mL) and low IGF-BP3 at 2.6 mg/L (3.1 – 8.9 mg/L). Bone age per the standards of Greulich and Pyle was delayed at 14 years with a predicted adult height of 68 inches. …”
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    THU131 Functional Hypogonadotropic Hypogonadism And Failure To Thrive In A Poorly Controlled Type 1 Diabetes Patient
  16. 149936
    “…Overall, 62 of the 159 children (67%) had evidence of pseudo-precocious puberty at time of diagnosis which was the most frequent group of symptoms in genotype group B: 8.2%, C: 23.3% and D: 3.8%. Bone age advancement was significantly more advanced at the time of diagnosis in males compared to females (p=0.0009). …”
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    THU187 Genotype-Phenotype Correlation, Clinical Presentation And Feminizing Surgery In Children With Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency: A Nationwide Multi-Center Study
  17. 149937
    “…Surveillance imaging shows mediastinal adenopathy, left pleural thickening, and bone and liver metastases. DISCUSSION: Anaplastic transformation is not uncommon (1). …”
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    SAT576 Change Is Not Always For The Best! A Transformation of Papillary Into Metastatic Anaplastic Thyroid Carcinoma
  18. 149938
    “…Common clinical features include mild-to-moderate intellectual impairment, low basal metabolic rate (BMR), mild skeletal dysplasia, normocytic anemia, bradycardia, consistent with high expression of THRA in brain, heart, gastrointestinal tract, skeletal muscle, and bone. TSH is normal to slightly increased, free T4 is low to low normal, and free T3 is normal to modestly elevated. …”
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    FRI479 Resistance To Thyroid Hormone Due To Thyroid Hormone Receptor Alpha (THRA) Gene Mutation
  19. 149939
    “…Hand X-ray: decrease joint space and bone erosion. Thyroid US: normal size, vascularity, no nodule. …”
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    SAT580 Incidental Diagnosis Of Genetic Variant PTPN11 Noonan Syndrome With Multiple Lentigines, Sensorineural Hearing Loss And Rheumatoid Arthritis In Adult Female With Hashimoto’s Thyroiditis. Case Report
  20. 149940
    “…Sonogram revealed a heterogeneous, hypervascular thyroid. Bone densitometry, echocardiogram, and Holter monitor studies were normal. …”
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    FRI476 Asymptomatic Thyrotropin-secreting Pituitary Microadenoma With Biochemical Secondary Hyperthyroidism: A Diagnostic Conundrum
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