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  1. 14681
    “…Our insights allowed us to evaluate the magnitude of the interactions between vertebrates and an incipient domesticated tree, in a cultural landscape and highly threatened environment, under a basal foodweb approach with implications for bottom-up and top-down forces. The results contribute to understanding animal-plant relationships, including concepts that can be replicated for other sessile prey and mobile predators in any region or habitat under different gradients of management. …”
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    The ecological footprint of Acca sellowiana domestication maintains the residual vertebrate diversity in threatened highlands of Atlantic Forest
  2. 14682
    “…Costs were estimated for each activity using an ingredients-based, bottom-up costing tool designed by the authors. The health impact and cost-effectiveness of the Action Plan were assessed by simulating its four priority interventions (HBV birth dose vaccination, PMTCT, HBV treatment and HCV treatment) using previously developed models calibrated to South Africa’s demographic and epidemic profile. …”
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    The investment case for hepatitis B and C in South Africa: adaptation and innovation in policy analysis for disease program scale-up
  3. 14683
    “…Propensity score matching shows that PFHI contributes to a marginal reduction (1%) in ‘catastrophic health expenditure incidence at the 25% threshold’ (CHE-25) for the bottom three quintiles. The reported coverage of PFHIs was greater in the upper income quintiles. …”
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    Effectiveness of government strategies for financial protection against costs of hospitalization Care in India
  4. 14684
    “…Two Australian examples, one largely top-down, predicated on applying new standards across the country, and the other largely bottom-up, adopting medical emergency teams in over 200 hospitals, provide empirical support for a complexity-informed approach to implementation. …”
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    When complexity science meets implementation science: a theoretical and empirical analysis of systems change
  5. 14685
    “…For dyspnea, the LS mean (95% CI) was 8.86 (5.05-15.52) in the bottom quartile and 2.87 (1.62-5.08) in the top quartile (p for trend = 0.005). …”
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    Dietary pattern and health-related quality of life among breast cancer survivors
  6. 14686
    “…Rather, changes were spurred by a country-level initiative, and a set of strategically framed arguments that resonated with funders and country-level actors. This bottom-up approach, supported by normative agencies, was transformative. …”
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    UNICEF’s contribution to the adoption and implementation of option B+ for preventing mother-to-child transmission of HIV: a policy analysis
  7. 14687
    “…However, their potential contributions towards programme implementation tended to be unrecognized both at the top and bottom of the policy implementation chain. These actors constantly struggled for recognition and used different mechanisms to position themselves alongside other actors within the programme that further complicated the relationships between different actors. …”
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    Understanding the complex relationships among actors involved in the implementation of public-private mix (PPM) for TB control in India, using social theory
  8. 14688
    “…BACKGROUND: There is a compelling need for management training amongst hospital managers in Nigeria mostly because management was never a part of the curricula in medical schools and this has resulted in their deficiencies in effective policymaking, planning and bottom line management. There has been no study to the best of our knowledge on the need and likely factors that may influence the acquisition of such training by hospital managers and this in effect was the reason for this study. …”
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    Assessing the predictors for training in management amongst hospital managers and chief executive officers: a cross-sectional study of hospitals in Abuja, Nigeria
  9. 14689
    “…BACKGROUND: Severe underutilization of healthcare facilities and lack of timely, affordable and effective access to healthcare services in resource-constrained, bottom of pyramid (BoP) settings are well-known issues, which foster a negative cycle of poor health outcomes, catastrophic health expenditures and poverty. …”
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    Underlying determinants of health provider choice in urban slums: results from a discrete choice experiment in Ahmedabad, India
  10. 14690
    “…In 938 participants with baseline eGFR ≥60 mL/min/1.73 m(2), the incidence of eGFR <60 mL/min/1.73 m(2) at follow-up was 8.0% versus 4.1% in the top versus the bottom halve of baseline dp-ucMGP. For a 5-fold higher plasma dp-ucMGP at baseline, eGFR at follow-up decreased by 3.15 mL/min/1.73 m(2) [95% confidence interval (CI) 1.26–5.05; P = 0.001]. …”
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    Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population
  11. 14691
    por Gibbons, Elizabeth, Fitzpatrick, Ray
    Publicado 2018
    “…CONCLUSIONS: The current study supports the view that a bottom-up approach is a promising method to generate PROM-related insights that are relevant to patients and health professionals. …”
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    An alternative approach to implementing patient-reported outcome measures
  12. 14692
    “…Thus, the ability to rapidly and accurately identify putative sulfenylation sites in proteins will provide important insights into redox-dependent regulation of protein function in a variety of cellular contexts. Though bottom-up proteomic approaches, such as tandem mass spectrometry (MS/MS), provide a wealth of information about global changes in the sulfenylation state of proteins, MS/MS-based experiments are often labor-intensive, costly and technically challenging. …”
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    SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites
  13. 14693
    “…The physical position of the red locus in RZS should be in the 368.6 kb candidate interval at the bottom of LG4. CONCLUSIONS: The genetic locus responsible for the red tender shoots of RZS was located in the same interval of the red fruit skin gene of MRB, meaning that the bud mutation loci of RZS and MRB may be the same or adjacent to each other, and the red shoot trait and the red fruit skin trait in RZS may be controlled by the same, or a closely linked locus. …”
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    The genetic locus underlying red foliage and fruit skin traits is mapped to the same location in the two pear bud mutants ‘Red Zaosu’ and ‘Max Red Bartlett’
  14. 14694
    “…Athletes who injure either the top or bottom hand can return to play at the same elite level following this injury.…”
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    Return to Play After PRP and Rehabilitation of 3 Elite Ice Hockey Players With Ulnar Collateral Ligament Injuries of the Elbow
  15. 14695
    “…RESULTS—: SVD score was associated with increasing mean baseline systolic BP (SBP; odds ratio of top versus bottom BP quartile: 2.28; [95% CI, 1.62–3.21]; P<0.0001) and with prior hypertension (2.53; [95% CI, 2.01–3.20]; P<0.0001), but the association was much stronger with mean premorbid SBP (6.09; [95% CI, 4.34–8.55]; P<0.0001). …”
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    Long-Term Premorbid Blood Pressure and Cerebral Small Vessel Disease Burden on Imaging in Transient Ischemic Attack and Ischemic Stroke: Population-Based Study
  16. 14696
    “…The metaGRS stratified individuals into significantly different life course trajectories of CAD risk, with those in the top 20% of metaGRS distribution having an HR of 4.17 (95% CI: 3.97 to 4.38) compared with those in the bottom 20%. The corresponding HR was 2.83 (95% CI: 2.61 to 3.07) among individuals on lipid-lowering or antihypertensive medications. …”
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    Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention
  17. 14697
    “…CONCLUSIONS: The recommendations of the present study are to encourage hospital personnel to create their own solutions for various situations on the care continuum, and to disseminate them within their units to achieve a bottom up change, in lieu of investing in new or specific written guidelines. …”
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    Beyond the hospital infection control guidelines: a qualitative study using positive deviance to characterize gray areas and to achieve efficacy and clarity in the prevention of healthcare-associated infections
  18. 14698
    “…Three times as many students in the top EduYears GPS decile went to a selective school compared to the bottom decile. These results were mirrored in the exam differences between school types. …”
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    Differences in exam performance between pupils attending selective and non-selective schools mirror the genetic differences between them
  19. 14699
    “…The French Ministry of Health plans to extend the experimentation to other regions and probe the relevance of this type of ‘bottom–up’ territorial prevention policy at the national level. …”
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    Combining brief contact interventions (BCI) into a decision-making algorithm to reduce suicide reattempt: the VigilanS study protocol
  20. 14700
    “…However, these ratios are closely related to the shapes of the micro-columns and the incident positions of X-ray on the cross-sections of the micro-columns, especially for the circular micro-column. The sequence of bottom light outputs stimulated by a uniform flood field of X-ray from high to low corresponds to the circular, square and hexagonal CsI(Tl) micro-columns with the same cross-section areas. …”
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    Simulated performances of pixelated CsI(Tl) scintillation screens with different micro-column shapes and array structures in X-ray imaging
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