“…Data was divided into three subpopulations based on phenotype distribution (bottom 5%, middle 90%, top 5%). Marker data were simulated to mimic a 770 K and 1.5 million SNP marker panel. …”
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“…A conceptual framework that structures existing insights and provides concrete directions for policymaking is also missing. METHODS: To gain a bottom-up perspective, we gather qualitative data through semi-structured interviews with different levels of health workers and users of health services in rural and urban Rwanda. …”
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“…For 33 and 66 ft. dives, we consistently found significant decreases in heart rates (HR) and concomitant increases in parasympathetic activities as estimated via the PDM and root mean square of successive differences (RMSSD) for all time intervals (from the first 5 min to the last 30 min) at the bottom depth when compared to the baseline depth at sea level. …”
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“…At the mouth of the Amazon River, a widespread carbonate ecosystem exists below the river plume, generating a hard-bottom reef (∼9500 km(2)) that includes mainly large sponges but also rhodolith beds. …”
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“…A possible explanation might come from the distinction between bottom-up (i.e., sensory input) and top-down (i.e., cognitive representation of body schema) mechanisms that influence multisensory integration, that is, altered cognitive representations may influence embodiment but not proprioceptive drift.…”
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“…Approximately 4 ml of bovine blood was placed on the bottom surfaces of inverted Styrofoam cups and then the PTFE membranes were thinly stretched over the surfaces. …”
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“…The sister species Cottus hangiongensis and C. koreanus are small bottom-dwelling freshwater sculpin fishes from South Korea that display marked life history divergence but are morphologically nearly indistinguishable. …”
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“…Pearson’s correlation coefficients indicated the variables most strongly correlated with soil drainage were topographic wetness index (−0.34), mid-slope position (−0.29), multi-resolution valley bottom flatness index (−0.29) and vertical distance to channel network (VDCN) (0.26). …”
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“…RESULTS: Overall mortality was significantly increased in patients in the top quartile of CRP (HR = 2.52, 95% CI: 1.82–3.49), IL-6 (HR = 2.78, 95% CI: 2.03–3.81), sTNF-RII (HR = 2.00, 95% CI: 1.46–2.72), and MIC-1 (HR = 2.53, 95% CI: 1.83–3.50), compared to those in the bottom quartile (P-trend <0.0001 for all four comparisons). …”
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“…The aim of this study is to verify whether this is an adequate model for funding stroke hospital admissions, and to explore which risk factors and complications may influence the amount of funding. METHODS: A bottom-up analysis of 2496 ischaemic stroke admissions in Belgium compares detailed in-hospital resource use (including length of stay, imaging, lab tests, visits and drugs) per SOI category and calculates total hospitalisation costs. …”
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“…There was a significant increase in hypertension risk with LAP levels in the fourth quartile as compared with the bottom quartile (OR: 3.31, 95%CI: 1.76–6.25). The AUC of LAP was significantly different than that of BMI in males (Z = 2.158, p = 0.0309) and females (Z = 3.570, p = 0.0004), while only performed better in females as compared with that of WHtR (Z = 2.166, p = 0.0303). …”
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“…After adjustment for major lifestyle and dietary risk factors of CHD, weak but significantly positive associations were observed for glucosinolates with CHD risk when comparing the top with bottom quintiles (hazard ratio [HR]:1.09; 95% CI: 1.01, 1.17; P(trend)<0.001). …”
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“…Mothers who score in the top and bottom 20th percentile of change scores will be invited to participate in a semi-structured telephone interview exploring maternal experiences with infant feeding in the NICU. …”
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“…Comparing top versus bottom thirds of baseline levels, pooled relative risks for arsenic and lead were 1.30 (95% confidence interval 1.04 to 1.63) and 1.43 (1.16 to 1.76) for cardiovascular disease, 1.23 (1.04 to 1.45) and 1.85 (1.27 to 2.69) for coronary heart disease, and 1.15 (0.92 to 1.43) and 1.63 (1.14 to 2.34) for stroke. …”
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“…The role of temporary carbon storage in forest products has been analysed and debated in the scientific literature, but detailed bottom-up studies mapping the fate of harvested materials and quantifying the associated emission profiles at national scales are rare. …”
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“…While previously identified anaerobic members of the microbial community disappear from the water column during drought and bloom, sediment samples suggest that these microorganisms survive at the lake bottom or in the subsurface. Thus, the sediments may represent a type of seed bank that could restore the microbial community as a bloom subsides. …”
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“…Ten fractions (F1-10) were collected from top to bottom. Fractions with the highest EV content were further purified by ultracentrifugation, size exclusion, or bind-elute chromatography. …”
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“…Here, we report the identification of Glycine max (soybean) endocytosis dynamin-like protein 5A (GmSDL5A) associated with purified soybean mosaic virus (SMV) virions from soybean using a bottom-up proteomics approach. Knockdown of GmSDL5A and its homologous gene GmSDL12A inhibits SMV infection in soybean. …”
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“…Conclusion: These findings suggest that a bottom–up effect induced by the EIMS reduced the analgesic use, improved pain, and disability due to chronic MPS. …”
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“…Because it receives water with high and low salinities, salinity stratification is producing in the Lake Timsah, with values of 14–40‰ for the surface water and over 40‰ for the bottom water. The temperature of the lake water decreased to below 19 °C in the winter and rose to above 29 °C in the summer; the concentration of dissolved oxygen ranged between 6.5 and 12.2 l(−1) and the pH fluctuated between 7.9 in its lower value and 8.2 in its higher value. …”
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