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  1. 15501
    “…METHODS: In the study populations of the CANVAS Program and CREDENCE trials, weight change was evaluated between randomization and week 52–78, defining subjects in the top 10% of the entire distribution of weight changes as gainers, subjects in the bottom 10% as losers and the remainder as stable. …”
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    Extremes of both weight gain and weight loss are associated with increased incidence of heart failure and cardiovascular death: evidence from the CANVAS Program and CREDENCE
  2. 15502
    “…Among the top 20% of patients for predicted treatment benefit, exacerbations were reduced by 2.23/year (95% CI, 2.03‒2.43) and ACQ5 score were reduced by 0.59 (95% CI, 0.19‒0.98). Among the bottom 20% of patients for predicted treatment benefit, exacerbations were reduced by 0.25/year (95% CI, 0.16‒0.34) and ACQ5 by -0.20 (95% CI, -0.51 to 0.11). …”
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    Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials
  3. 15503
    “…The method’s ability to detect PCT was confirmed by comparing the results with LC–MS bottom-up workflow. The new method detects intact PCT by its m/z and uncovers its alternations in septic serum. …”
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    The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips
  4. 15504
    “…The mean equivalent BVE cut-off over all patients for every catheter was calculated for the reference cut-offs of 0.1 mV, 0.2 mV, 0.5 mV, 1.0 mV, and 1.5 mV (Figure, bottom left). RESULTS: Correlation between the four different BVE maps for the 25 patients showed a slight individual variation between the patients. …”
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    Association between different catheter designs for the characterization of the left atrial substrate
  5. 15505
    “…Bacterial and fungal phyllosphere microbiome richness was lowest in samples from the top of the canopy, subsequently increasing in the middle and then bottom canopy samples. These differences maybe driven by either by (1) exchange of microbiomes with the forest floor and soil with the lower foliage, (2) strong ecological filtering in the upper canopy via environmental exposure (e.g., UV), (3) canopy density, (4) or combinations of factors. …”
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    What matters most? Assessment of within-canopy factors influencing the needle microbiome of the model conifer, Pinus radiata
  6. 15506
    “…Cases with TCR clones in the top tertile in the pretreatment tissue or in circulation had significantly better survival than the bottom two tertiles (p<0.04). Furthermore, a high number of shared TCR clones between pretreatment tissue and in circulation was associated with improved survival (p=0.01). …”
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    Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy
  7. 15507
    “…We examined the myofibrillar (MyoF) and non-myofibrillar (non-MyoF) proteomic profiles of the vastus lateralis (VL) muscle of younger (Y, 22±2 years old; n=5) and middle-aged participants (MA, 56±8 years old; n=6), and MA following eight weeks of knee extensor resistance training (RT, 2d/week). Shotgun/bottom-up proteomics in skeletal muscle typically yields wide protein abundance ranges that mask lowly expressed proteins. …”
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    A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training
  8. 15508
    “…These included environmental and occupational risk factors, which are more likely to use bottom-up approaches for health outcomes where disease envelopes may not be available. …”
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    Burden of disease attributable to risk factors in European countries: a scoping literature review
  9. 15509
    “…Most beekeepers (88.0%) treated against the Varroa mite, although only one method was reported, tau-fluvalinate as Apistan strips, and only 41.7% used a screened bottom board. The results establish a benchmark for future beekeeper surveys in Saudi Arabia and other environmentally similar countries where colony losses are of interest in all seasons of the year. …”
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    Seasonal Colony Loss Rates and Honey Bee Management in the Kingdom of Saudi Arabia: Results of a Survey of Beekeepers
  10. 15510
    “…METHODS: This study was conducted from the supplementary health system (SSS) perspective and followed the methodological guidelines related to cost-of-illness studies. A bottom-up (person-based) approach was used to assess the use of health resources to monitor and manage AEs during the use of PD-1 inhibitors, which made it possible to capture differences in the mean frequency of the use of health services with stratification results for different subgroups. …”
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    Does it fit in your pocket? economic burden of PD-1 inhibitors' toxicity in the supplementary health system: evidence from Brazil
  11. 15511
    “…The top (“High” Acceptability) and bottom (“Low” Acceptability) tertiles were invited to participate in a 30-minute semi-structured qualitative interview from 6/2021 to 10/2021 until thematic saturation was reached in each acceptability group. …”
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    An innovative sequential mixed-methods approach to evaluating clinician acceptability during implementation of a standardized labor induction protocol
  12. 15512
    “…Repeat pituitary MRI showed small hypo enhancement at the bottom of Sella suspicious for pituitary adenoma recurrence. …”
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    SAT627 Is Cyberknife Stereotactic Radiosurgery Effective For Treating Cushing’s Disease?
  13. 15513
    “…The EBV value and average NCOC, NGE, and PGE for the top 10% donors presented extreme differences to those for the bottom 10% donors for NCOC (24.02 versus 2.60), NGE (3.42 versus 0.36), and PGE (30.54% versus 3.46%). …”
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    Phenotypic and Genetic Analyses of In Vitro Embryo Production Traits in Chinese Holstein Cattle
  14. 15514
    “…[Figure: see text] Two bar charts with the top bar chart demonstrating the frequency of each infectious organism and the bottom bar chart demonstrating the frequency of each infection site. …”
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    2718. Prevalence of Infections Following Anti-CD30 Targeted Chimeric Antigen Receptor T-cell Therapy for Relapsed and Refractory Lymphoma
  15. 15515
    “…There was a disproportionate emphasis on the bottom-up approach across the documents, which presents the risk of diminishing government interest in place-based approaches, potentially burdening communities experiencing disadvantage beyond their capacities. …”
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    Government, governance, and place-based approaches: lessons from and for public policy
  16. 15516
    “…BACKGROUND: Commercial poultry production systems follow a pyramidal structure with a nucleus of purebred animals under controlled conditions at the top and crossbred animals under commercial production conditions at the bottom. Genetic correlations between the same phenotypes on nucleus and production animals can therefore be influenced by differences both in purebred-crossbred genotypes and in genotype-by-environment interactions across the two environments, known as macro-genetic environmental sensitivity (GES). …”
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    Micro-genetic environmental sensitivity across macro-environments of chickens reared in Burkina Faso and France
  17. 15517
    “…Its effect was continuous, substantial throughout the UK normal range [relative risk, top vs. bottom decile of this ratio, 7.3 (95% CI 5.8–9.2)] and varied little with age. …”
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    The joint effects of apolipoprotein B, apolipoprotein A(1), LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls†
  18. 15518
    “…RESULTS: Neither circulating levels of IGF-I (OR=1.21, 95% CI 0.75–1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR=1.00, 95% CI 0.66–1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR=1.22, 95% CI 0.75–1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. …”
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    Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
  19. 15519
    “…PHT (64%) was the most common drug to cause ADR, CBZ was at the bottom of the list to cause adverse effect (11.6%). …”
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    Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital
  20. 15520
    “…Women in the top PD quintile (or BI-RADS 4) had 8.26 (4.28 to 15.96), 3.94 (2.26 to 6.86), 3.38 (2.00 to 5.72), 2.99 (1.76 to 5.09), 2.55 (1.46 to 4.43) and 2.96 (0.50 to 17.5) times the risk of those in the bottom one (or BI-RADS 1), respectively, for Volpara, Quantra, Cumulus, SXA, ImageJ-based method, and BI-RADS (P for trend <0.0001 for all). …”
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    Digital mammographic density and breast cancer risk: a case–control study of six alternative density assessment methods
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