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  1. 15661
    por Imamura, Fumiaki, Fretts, Amanda M., Marklund, Matti, Ardisson Korat, Andres V., Yang, Wei-Sin, Lankinen, Maria, Qureshi, Waqas, Helmer, Catherine, Chen, Tzu-An, Virtanen, Jyrki K., Wong, Kerry, Bassett, Julie K., Murphy, Rachel, Tintle, Nathan, Yu, Chaoyu Ian, Brouwer, Ingeborg A., Chien, Kuo-Liong, Chen, Yun-yu, Wood, Alexis C., del Gobbo, Liana C., Djousse, Luc, Geleijnse, Johanna M., Giles, Graham G., de Goede, Janette, Gudnason, Vilmundur, Harris, William S., Hodge, Allison, Hu, Frank, Koulman, Albert, Laakso, Markku, Lind, Lars, Lin, Hung-Ju, McKnight, Barbara, Rajaobelina, Kalina, Riserus, Ulf, Robinson, Jennifer G., Samieri, Cecilia, Senn, Mackenzie, Siscovick, David S., Soedamah-Muthu, Sabita S., Sotoodehnia, Nona, Sun, Qi, Tsai, Michael Y., Tuomainen, Tomi-Pekka, Uusitupa, Matti, Wagenknecht, Lynne E., Wareham, Nick J., Wu, Jason H. Y., Micha, Renata, Lemaitre, Rozenn N., Mozaffarian, Dariush, Forouhi, Nita G.
    Publicado 2020
    “…Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41–1.66; p < 0.001) for 16:0, 1.40 (1.33–1.48; p < 0.001) for 16:1n-7, 1.14 (1.05–1.22; p = 0.001) for 18:0, and 1.16 (1.07–1.25; p < 0.001) for 18:1n9. …”
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    Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies
  2. 15662
    “…There was heterogeneity in some of the reported methods used such cost allocation, amortisation and the use of top-down, bottom-up or mixed approaches to the costing. Uncertainty checking through sensitivity analysis was only reported on by half of the papers (54%), while purposive and convenience sampling was reported by 72% of papers. …”
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    A Systematic Review of Methodological Variation in Healthcare Provider Perspective Tuberculosis Costing Papers Conducted in Low- and Middle-Income Settings, Using An Intervention-Standardised Unit Cost Typology
  3. 15663
    “…There were four blocks of dependent measures: individual driving performance (accelerations, decelerations, crashes, distance to lead vehicle, speed and fuel consumption), emotional dimensions (measures of skin conductance and self-reports of affective states concerning valence, arousal, and dominance), and visual behavior (fixations count and average duration, dwell times, and revisits) concerning three regions of the driving scene (the Top Rear Car –TRC- or the Bottom Rear Car –BRC- of the leading vehicle and the surrounding White Space Area -WSA). …”
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    Distressed in the queue? Psychophysiological and behavioral evidence for two alternative car-following techniques
  4. 15664
    “…Multiple RD users were likely to be aged 26–30 years (vs. 18–25 and > 30 years), live in non-local cities (vs. local cities), never married (vs. married), have a high monthly income (vs. no income and 1–599 USD), use versatile positions during anal intercourse (vs. top or bottom), and have inadequate HIV-related prevention knowledge (vs. adequate). …”
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    Use of multiple recreational drugs is associated with new HIV infections among men who have sex with men in China: a multicenter cross-sectional survey
  5. 15665
    “…After adjustment, adolescents in the top quartile had greater odds of all outcomes in early adulthood: nicotine dependency (odds ratio, OR = 5.37, 95% confidence interval, CI = 3.64–7.93); daily smoking (OR = 5.10, 95% CI =3.19–8.17); obesity (OR = 4.84, 95% CI = 3.33–7.03); high waist circumference (OR = 2.48, 95% CI = 1.94–3.16); harmful drinking (OR = 2.04, 95% CI = 1.57–2.65); and high waist-hip ratio (OR = 1.88, 95% CI = 1.30–2.71), compared to the bottom quartile. In latent class analysis, adolescents characterised by consistently high-risk behaviours throughout adolescence were at higher risk of all cancer risk behaviours at age 24, except harmful drinking. …”
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    Young adult cancer risk behaviours originate in adolescence: a longitudinal analysis using ALSPAC, a UK birth cohort study
  6. 15666
    “…METHODS: AIF splicing induction in brain was determined by multiple approaches including 5′ RACE, Sanger sequencing, splicing-specific PCR assay and bottom-up proteomic analysis. The role of AIF splicing in mitochondria and neurodegeneration was determined by its biochemical properties, cell death analysis, morphological and functional alterations and animal behavior. …”
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    AIF3 splicing switch triggers neurodegeneration
  7. 15667
    “…The 5637 and T24 cells O-glycome was characterized by mass spectrometry (MS), and the obtained information was used to guide glycoproteomics experiments, combining sialidase, lectin affinity and bottom-up protein identification by nanoLC-ESI-MS/MS. …”
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    Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer
  8. 15668
    “…Costs were estimated retrospectively using the ‘ingredients approach’, combining ‘bottom-up’ and ‘top-down approaches’, from the societal perspective. …”
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    Cost of community-led larval source management and house improvement for malaria control: a cost analysis within a cluster-randomized trial in a rural district in Malawi
  9. 15669
    “…Eight studies used a bottom-up approach for costing, and six used a top-down approach. …”
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    Economic Burden of Multiple Sclerosis in Low- and Middle‐Income Countries: A Systematic Review
  10. 15670
    “…Greater mortality was recorded at the top and middle sections of sprayed wall compared to the bottom portion near the floor. CONCLUSION: KOPZ provided longer residual activity on all surfaces compared to ACS. …”
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    Variable residual activity of K-Othrine® PolyZone and Actellic® 300 CS in semi-field and natural conditions in the Democratic Republic of the Congo
  11. 15671
    “…Micro-costing technique and a bottom-up approach was used comprising all medical direct costs from the hospital perspective. …”
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    The addition of neoadjuvant pertuzumab for the treatment of HER2+ breast cancer: a cost estimate with real-world data
  12. 15672
    “…We will use a mixed costing methodology (ie, a combination of top–down and bottom–up approaches) considering 4 cost categories: intervention (CONEMO related) costs, health care costs, patient and family costs, and productivity costs. …”
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    A Mobile Health Intervention for Patients With Depressive Symptoms: Protocol for an Economic Evaluation Alongside Two Randomized Trials in Brazil and Peru
  13. 15673
    “…As part of this project, the FABIANA-checklist was developed, based on a multi-informant perspective and a multimodal bottom-up approach. The present study focusses on the process of item generation, item selection and psychometric validation of the checklist. …”
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    The development and psychometric evaluation of FABIANA-checklist: a scale to assess factors influencing treatment initiation in anorexia nervosa
  14. 15674
    por Souza, Gregory E, de Souza, Flávio Henrique Batista, Aguiar dos Reis, Marconi A, Dorim, Raoni A, Cristine Oliveira Gonçalves, Elisângela C, Floriano, Ana Luiza Silva, Tavares, Bruna de Souza, de Oliveira, André Magalhães, Ribeiro, Daniela Da Guarda, de Sá, Felipe Gonçalves, Lacerda, Júlia O, Caetano, Leandra Vieira, Augusto, Ludmila Rodrigues, Santos, Maria Luiza Costa, Viana, Otávio Reis, Soares, Alef Santos, de Medeiros, Felipe Ferreira, Figuereido, Amanda Luiza Alves, Calderón, Sergio Alfredo Hidalgo, Rojas Puell, María José, Quispe Chauca, Andrea del Carmen, Almeida, Maria Cristina, de Araújo, Arthur André Martins, Rodrigues, Artur Moreira, de Sá Rodrigues, Cátia Ribeiro, Morais, Jefferson Ricardo Rodrigues, Cardoso, Larissa Ludgero Soares, Colbert Câmara, Matheus Álvaro, Lopes, Pedro Alcântara Antunes, de Resende, Mateus Augusto Mendonça, de Oliveira, João Pedro Amaral, de Souza, Pedro Henrique Gonçalves, de Souza, Izadora Serdeira, Leal, Samara Soares, Aguiar, Mariana, de Faria, Maria Luiza Brandão, Ferreira, Paula G, Rocha, Leonora de Oliveira, Montes, Fernanda Luíza Pinheiro, Rocha, Luiz Felipe Oliveira
    Publicado 2021
    “…[Image: see text] Hospital scenario and dialogue window between doctor (player in black) and patient (non playable character) are displayer in the game engine software (Unity 2D). On the bottom half of the screen, the dialogue box allows the player to collect the patient’s medical history. …”
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    969. Gamification for Infectious Diseases Medical Education: Creating a Videogame to Teach COVID 19 Diagnosis and Treatment to Medical Students
  15. 15675
    “…As part of its 2020 Marine Protection Strategy, these deep-water reef systems are now protected by a full bottom-trawling ban throughout Tristan da Cunha and representative no take areas on its seamounts. …”
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    Climate Mitigation through Biological Conservation: Extensive and Valuable Blue Carbon Natural Capital in Tristan da Cunha’s Giant Marine Protected Zone
  16. 15676
    “…In this work, based on the upper line of water resources utilization and the bottom line of water environmental quality of “Three Lines, Single Project”, a fuzzy optimization method was introduced into the Tingjiang River water resources optimal allocation and eco-compensation mechanism model, which is based on the interval two-stage (ITS) stochastic programming method. …”
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    Optimal Allocation of Water Resources and Eco-Compensation Mechanism Model Based on the Interval-Fuzzy Two-Stage Stochastic Programming Method for Tingjiang River
  17. 15677
    por Qi, Baohua
    Publicado 2022
    “…There are two directions: one is the top-down impact, the other is the bottom-up impact; It is mainly manifested in two typical ways: social mobilization and emotional social struggle in microblog public opinion. …”
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    ON THE EXPRESSION AND GUIDANCE OF NETWORK EMOTION IN EMERGENCIES FROM THE CHANGE OF EMOTIONAL BEHAVIOR -- TAKING THE RAINSTORM IN ZHENGZHOU ON JULY 20 AS AN EXAMPLE
  18. 15678
    “…One gram of milk powder (accurate to 0.01 g) was weighed into a 50 mL tip and bottom plug centrifuge tube. Acetonitrile-water (84:16, v/v) was set as the extraction agent for the first two cycles, and acetonitrile-methanol-water (45:10:45, v/v/v) was set as the third extraction agent. …”
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    固相萃取-超高效液相色谱-串联质谱法检测婴幼儿奶粉中的7种链格孢霉毒素
  19. 15679
    por LIU, Luyao, QIN, Hongqiang, YE, Mingliang
    Publicado 2021
    “…Mass spectrometry (MS)-based proteomics provides an excellent approach for the comprehensive analysis of proteins and their modifications. In bottom-up proteomics, glycoproteomic analysis is more difficult than other PTMs because intact glycopeptides have diverse peptide backbones and glycan chains, relatively low abundance and ionization efficiency, and pronounced heterogeneity. …”
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    完整糖基化肽段的富集与质谱解析新技术研究进展
  20. 15680
    “…Third, Singapore’s management policies have been made not only in a top-down, centralized style during the initial response stage, but also with a greater proportion of bottom-up approaches, particularly as the pandemic trudges on. …”
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    Moving toward a common goal via cross-sector collaboration: lessons learned from SARS to COVID-19 in Singapore
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