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  1. 641
    “…Although brown adipose tissue is important with regard to energy balance, the molecular mechanism of brown adipocyte differentiation has not been extensively studied. …”
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    Methyltransferase and demethylase profiling studies during brown adipocyte differentiation
  2. 642
    “…OBJECTIVE: Genetic background largely contributes to the complexity of metabolic responses and dysfunctions. Induction of brown adipose features in white fat, known as brown remodeling, has been appreciated as a promising strategy to offset the positive energy balance in obesity and further to improve metabolism. …”
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    Genetic backgrounds determine brown remodeling of white fat in rodents
  3. 643
    por Brown-Séquard, E.
    Publicado 1858
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    Dr. E. Brown-Séquard on the Physiology and Pathology of the Nervous System
  4. 644
    “…Recent studies revealed that acquisition of brown characteristics by white adipocytes, termed “browning,” may positively contribute to cellular bioenergetics and metabolism homeostasis. …”
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    Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization
  5. 645
    “…Not surprisingly, considerable attention has been placed on the discovery of methods to activate brown adipose tissue. A variety of plant-derived, natural compounds have shown promise to regulate brown adipose tissue activity and enhance the lipolytic and catabolic potential of white adipose tissue. …”
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    Phytochemicals as novel agents for the induction of browning in white adipose tissue
  6. 646
    “…In the present study MØ from Brown Swiss (BS) cattle produce significantly more RNS and less IL-1β when compared to cells from Holstein Friesian (HF) cattle in response to bacterial or fungal stimuli. …”
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    Differential macrophage function in Brown Swiss and Holstein Friesian cattle
  7. 647
    “…When we tested whether browning induced by clozapine can be explained by its known pharmacological effect of antagonizing serotonin (5HT) receptors, it was found that browning cells expressed 5HT receptors 2A, 1D, 7 and the upregulation of browning markers was diminished in the presence of exogenous 5HT. …”
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    Clozapine modifies the differentiation program of human adipocytes inducing browning
  8. 648
    “…Brown adipocytes regulate energy expenditure via mitochondrial uncoupling, which makes them attractive therapeutic targets to tackle obesity. …”
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    Dissecting the brown adipogenic regulatory network using integrative genomics
  9. 649
    “…Its brown colour is mainly attributed to densely packed capillaries, which facilitate its high heat-exchanging efficiency. …”
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    Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat
  10. 650
    por Baron, J. H.
    Publicado 1991
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    The Paterson-Brown Kelly Syndrome of Sideropenic Dysphagia Does Not Exist
  11. 651
    “…The phylogeny results show that there are four main clades of Chinese brown frogs. Excepting the three commonly known Chinese brown frog species groups, R. maoershanensis forms an independent clade nearest to the R. japonica group. …”
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    Phylogeny and biogeography of South Chinese brown frogs (Ranidae, Anura)
  12. 652
    “…INTRODUCTION: Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. …”
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    Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo
  13. 653
    “…The rediscovery of brown adipose tissue (BAT) in humans and its capacity to oxidize fat and dissipate energy as heat has put the spotlight on its potential as a therapeutic target in the treatment of several metabolic conditions including obesity and diabetes. …”
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    Brown Adipose Tissue Bioenergetics: A New Methodological Approach
  14. 654
    por Scheele, Camilla, Nielsen, Søren
    Publicado 2017
    “…This observation raise the possibility for feedback mechanisms in adult humans in terms of a brown fat-brain crosstalk, possibly mediated by batokines, factors produced by and secreted from brown fat. …”
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    Metabolic regulation and the anti-obesity perspectives of human brown fat
  15. 655
    por Wang, Jiexin, Tontonoz, Peter
    Publicado 2017
    “…In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. …”
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    Pioneering EBF2 remodels the brown fat chromatin landscape
  16. 656
    “…Here, we investigate the existence of pedal glands in brown bears and their role in chemical communication from a histological, biochemical and behavioural perspective. …”
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    Histological, chemical and behavioural evidence of pedal communication in brown bears
  17. 657
    “…The identification of brown adipose deposits in adults has led to significant interest in targeting this metabolically active tissue for treatment of obesity and diabetes. …”
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    Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes
  18. 658
    “…Interestingly, Mfn2 is highly expressed in brown adipose tissue (BAT), yet its role remains unexplored. …”
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    Mfn2 is critical for brown adipose tissue thermogenic function
  19. 659
    “…Obesity results from excess accumulation of white fat, while brown and its related beige fat function to dissipate energy as heat, thus counteracting obesity and its related metabolic disorders. …”
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    MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure
  20. 660
    “…Here we quantify, with unprecedented detail, the contribution of humans and climate change to the Holocene decline of the largest living terrestrial carnivore, the brown bear (Ursus arctos), on a continental scale. …”
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    Humans and climate change drove the Holocene decline of the brown bear
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