Materias dentro de su búsqueda.
Mostrando 1,501 - 1,520 Resultados de 1,554 Para Buscar '"CBE"', tiempo de consulta: 0.31s Limitar resultados
  1. 1501
    “…Importantly, de novo L1 insertions are rare during genome editing by prime editors (PE), cytidine or adenine base editors (CBE or ABE), consistent with their reduced DSB formation. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
  2. 1502
    “…Furthermore, the experiments of co-administration of β-glucosidase and pre-administered β-glucosidase inhibitor (Conduritol B epoxide, CBE) were used to clarify the mechanism of Z14G toxicity release. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells
  3. 1503
    “…Moreover, manual inspection revealed several TA systems that were not yet reported in P. aeruginosa including the hok-sok, cptA-cptB, cbeA-cbtA, tomB-hha, and ryeA-sdsR. Additional annotation revealed that a large number of MGEs were closely distributed with TA. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Characterization of toxin-antitoxin systems from public sequencing data: A case study in Pseudomonas aeruginosa
  4. 1504
    “…The effectiveness of Genie to teach key genetic drift concepts and misconceptions was assessed with the Genetic Drift Inventory developed by Price et al. (CBE Life Sci Educ 13(1):65–75, 2014). Overall, Genie performed comparably to that of traditional static methods across all evaluated classes. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Genie: an interactive real-time simulation for teaching genetic drift
  5. 1505
    “…To identify functional phosphorylation sites involved in 5‐fluorouracil (5‐FU) resistance during its treatment of colorectal cancer cells, CRISPR‐mediated cytosine base editor (CBE) and adenine base editor (ABE) are utilized for functional screens by mutating phosphorylated amino acids with two libraries specifically targeting 7779 and 10 149 phosphorylation sites. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR‐Mediated Base Editors
  6. 1506
    por Xue, Charlie Q L
    Publicado 2016
    “…Endorsement: “MTR’s Kowloon Station project offered my firm the unique opportunity to contribute to a new type of fully integrated three dimensional transport mega-structure, conceived as a well-connected place for people to live, work and play.Through Charlie Xue’s book, one can see how a compact city works and high density integrated development indicates a sustainable path for modern city making.” Sir Terry Farrell<, CBE, Principal, Farrells "Well researched and refreshingly well structured, Charlie Xue's latest book comprehensively shows how Hong Kong's post-war urban architecture both tracks and symbolizes the former British colony's rise to success - a must read for architecture and culture buffs alike." …”
    Enlace del recurso
    Enlace del recurso
    Hong Kong architecture 1945-2015: from colonial to global
  7. 1507
    “…Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base editors (ABEs). To develop a CBE that retains the small size, low off-target activity and high on-target activity of current ABEs, we evolved the highly active deoxyadenosine deaminase TadA-8e to perform cytidine deamination using phage-assisted continuous evolution. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
  8. 1508
    por Shaffer, Christopher D., Alvarez, Consuelo, Bailey, Cheryl, Barnard, Daron, Bhalla, Satish, Chandrasekaran, Chitra, Chandrasekaran, Vidya, Chung, Hui-Min, Dorer, Douglas R., Du, Chunguang, Eckdahl, Todd T., Poet, Jeff L., Frohlich, Donald, Goodman, Anya L., Gosser, Yuying, Hauser, Charles, Hoopes, Laura L.M., Johnson, Diana, Jones, Christopher J., Kaehler, Marian, Kokan, Nighat, Kopp, Olga R., Kuleck, Gary A., McNeil, Gerard, Moss, Robert, Myka, Jennifer L., Nagengast, Alexis, Morris, Robert, Overvoorde, Paul J., Shoop, Elizabeth, Parrish, Susan, Reed, Kelynne, Regisford, E. Gloria, Revie, Dennis, Rosenwald, Anne G., Saville, Ken, Schroeder, Stephanie, Shaw, Mary, Skuse, Gary, Smith, Christopher, Smith, Mary, Spana, Eric P., Spratt, Mary, Stamm, Joyce, Thompson, Jeff S., Wawersik, Matthew, Wilson, Barbara A., Youngblom, Jim, Leung, Wilson, Buhler, Jeremy, Mardis, Elaine R., Lopatto, David, Elgin, Sarah C.R.
    Publicado 2010
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions
  9. 1509
    “…Chemically-induced Gaucher macrophages were developed by differentiateing THP-1 monocytes to macrophages by treatment with phorbol 12-myristate 13-acetate (PMA) and then inhibiting intracellular GCase with conduritol B-epoxide (CBE), a specific irreversible inhibitor of GCase activity, and supplementing the medium with exogenous GlcCer. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Coenzyme Q(10) partially restores pathological alterations in a macrophage model of Gaucher disease
  10. 1510
    por Huang, Steve, Li, Hua, Ge, Junbo
    Publicado 2015
    “…H(2)S is produced endogenously through several key enzymes, including cystathionine β-lyase (CBE), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST)/cysteine aminotransferase (CAT). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway
  11. 1511
    “…The overall knowledge score was determined with sections on general knowledge, curability, symptoms, and screening; the overall attitude score concerned attitudes towards breast cancer, screening, and barriers; and the overall practices score was for breast self examination (BSE), clinical breast examination (CBE) and mammography. Bivariate and multivariate analyses of socioeconomic determinants were performed for each score. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Knowledge, Attitudes and Practices Regarding Breast Cancer amongst Lebanese Females in Beirut
  12. 1512
    “…Despite a trend in nursing education to adopt competency-based education (CBE) models, there is little in the nursing literature about programs based on a mastery model. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mastery learning in a bachelor’s of nursing program: the Roseman University of Health Sciences experience
  13. 1513
    “…Remarkably, while CTCF degradation suppressed most CBE-based chromatin interactions, it promoted robust RC interactions with, and robust V(H)-to-DJ(H) joining of, distal V(H)s, with patterns similar to those of “locus-contracted” primary pro-B cells. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
  14. 1514
    “…Thus, breast self-examination (BSE), followed by clinical breast examination (CBE), is the affordable method to downstage BC. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Impact of Educational Level and Family income on Breast Cancer Awareness among College-Going Girls in Shillong (Meghalaya), India
  15. 1515
    “…Among the targeted genes, we find that targeting splice-donors is the most reliable disruption method, followed by targeting splice-acceptors, and introducing pmSTOPs. Further, the CBE BE4 is more effective for disruption than the ABE ABE7.10, however this disparity is eliminated by employing ABE8e. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells
  16. 1516
    “…However, an important new tool for mtDNA mutagenesis has emerged recently, namely double-stranded DNA deaminase (DddA)-derived cytosine base editor (DdCBE). Here, we test this emerging tool for in vivo use, by delivering DdCBEs into mouse heart using adeno-associated virus (AAV) vectors and show that it can install desired mtDNA edits in adult and neonatal mice. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
  17. 1517
    “…If only acetic anhydride is used, the 15 CBE species (n=3) is obtained in high yield. Interesting intermolecular bonding is found in (Ph(4)P)(2)[Nb(6)Cl(i) (12)I(a) (6)] ⋅ 4CH(2)Cl(2) with I⋅⋅⋅I halogen bonding and π‐π bonding interactions between the phenyl rings of the cations in (PPN)(3)[Nb(6)Cl(i) (12)I(a) (5.047(9))Cl(a) (0.953)]. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Cluster Compounds with Oxidised, Hexanuclear [Nb(6)Cl(i) (12)I(a) (6)]( n−) Anions (n=2 or 3)
  18. 1518
    “…We also show that transfection of mDdCBE-encoding mRNA, rather than plasmid, can reduce off-target editing in human mitochondrial DNA.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Base editing in human cells with monomeric DddA-TALE fusion deaminases
  19. 1519
    “…Due to the low thermal stability of crystallographic boundaries, the grain boundary engineering (GBE) manifests some limits to the fineness and types of microstructures achievable, while unique chemical boundary engineering (CBE) enables us to create a metallic material with an ultrafine hierarchically heterogeneous microstructure for enhancing the mechanical properties of materials. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Hierarchical nano-martensite-engineered a low-cost ultra-strong and ductile titanium alloy
  20. 1520
    “…First, we fused DdCBEs to a nuclear export signal (DdCBE-NES) to avoid off-target C-to-T conversions in the nuclear genome and improve editing efficiency in mtDNA. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Enhanced mitochondrial DNA editing in mice using nuclear-exported TALE-linked deaminases and nucleases
Herramientas de búsqueda: RSS