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  1. 1541
    “…RESULTS: The splicing sites of PKM, a 5’ donor site of GT and a 3’ acceptor site of AG, were efficiently mutated by cytosine base editor (CBE; BE4max) and adenine base editor (ABE; ABEmax‐NG) with guide RNAs (gRNAs) targeting the splicing sites flanking exons 9 and 10 in HCT116 cells and/or zebrafish embryos. …”
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    Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo
  2. 1542
    “…To determine whether these compounds are broadly relevant for neuroprotection, we tested them on a conduritol-b-epoxide (CBE)-induced Gaucher disease (GD) model, in which the activity of glucocerebrosidase (GBA), a commonly known genetic risk factor for PD, was inhibited. …”
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    In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets
  3. 1543
    “…With base editors including adenine base editor (ABE), cytidine base editor (CBE), and glycosylase base editor (GBE), 76.3% of single nucleotide variations (SNVs) and 58% of all mutations in USH2A are correctable. …”
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    Global spectrum of USH2A mutation in inherited retinal dystrophies: Prompt message for development of base editing therapy
  4. 1544
    por Ellis, Jonathan R.
    Publicado 2022
    “…</span></span></span></p> <p><span><span><span>He was elected a Fellow of the Royal Society of London in 1985, was appointed a </span><span><span>Commander of the Order of the British Empire (CBE) in 2012 for his services to science and technology</span></span><span><span>,</span></span><span>&nbsp;was elected&nbsp;</span><span>in 2015 </span><span>a Foreign Fellow of the Indian National Science Academy and a Foreign Member of the Estonian Academy of Sciences, and has been awarded several honorary doctorates.…”
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    Theory: Historical perspective and what have we learned from the Higgs so far
  5. 1545
    “…The objective of this study is to investigate the relationship between spiritual care-giving competency (SCG) and nursing core competencies (NCC) among Chinese nursing interns, adopting a competency-based education (CBE) perspective, additionally, the study aims to examine how emotional intelligence (EI) serves as a mediator in this relationship. …”
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    Emotional intelligence as a mediator between spiritual care-giving competency and core competencies in Chinese nursing interns: a cross-sectional study
  6. 1546
    “…Results included ipsilateral (IBTR), contralateral (CBE), and distant metastasis-free (DMFS) breast progression-free survival, as well as overall survival (OS). …”
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    A single-institution retrospective analysis of intraoperative radiation boost during breast-conservation treatment for breast cancer
  7. 1547
    por Pengpid, Supa, Zhang, Chao, Peltzer, Karl
    Publicado 2021
    “…RESULTS: The prevalence of past 2 years mammography screening was 21.7% among women aged 50-74 years, past year CBE 15.9% among women aged 40 years and older, past 3 years Pap smear or VIA 32.6% among women 21-65 years, past year FOBT 21.8% among women and 22.3% among men aged 50-75 years, and past 10 years colonoscopy 9.1% among women and 7.3% among men aged 50-75 years. …”
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    The Prevalence and Associated Factors of Cancer Screening Uptake Among a National Population-Based Sample of Adults in Marshall Islands
  8. 1548
    “…Regarding breast examination, 42.6% performed BSE; 10.1% had Clinical Breast Examination (CBE), while 2.3% had undergone mammography in the three years preceding the study. …”
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    Breast cancer awareness, risk factors and screening practices among future health professionals in Ghana: A cross-sectional study
  9. 1549
    por Mwakigonja, Amos Rodger
    Publicado 2016
    “…However, this training was largely knowledge-based and thus the need to shift towards competency-based education (CBE) and full modularization necessitated this study. …”
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    The Doctor of Medicine curriculum review at the School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania: a tracer study report from 2009
  10. 1550
    “…Outcomes included ipsilateral (IBTR) and contralateral breast progression-free survival (CBE), distant metastasis-free survival (DMFS), and overall survival (OS). …”
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    Intraoperative radiotherapy boost as part of breast-conservation therapy for breast cancer: a single-institution retrospective analysis
  11. 1551
    “…We leverage these improvements to develop a highly mutagenic LbCas12a nuclease and a LbCas12a-CBE demonstrating that the optimizations can be broadly applied to the Cas12a toolbox. …”
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    Systematic optimization of Cas12a base editors in wheat and maize using the ITER platform
  12. 1552
    “…To improve meat production of Chinese indigenous pigs, we used cytosine base editor 3 (CBE3) to introduce IGF2-intron3-C3071T mutation into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer (SCNT) to generate the founder line of IGF2(T/T) pigs. …”
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    Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs
  13. 1553
    “…FUNDING: The Moulton Foundation, the Berkeley Foundation, the Multiple Sclerosis Trials Collaboration, the Rosetrees Trust, a personal contribution from A W Pidgley CBE, and the National Institute for Health Research University College London Hospitals Biomedical Research Centre and University College London.…”
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    Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial
  14. 1554
    “…CE and HAM were supported by Medical Research Council Doctoral Training Grants (C.B.E. 1644194, H.A.M MR/K501347/1). HMM and UB were employed by Eli Lilly & Co during the study; HMM is currently an employee of Boehringer Ingelheim Pharma GmbH & Co KG. …”
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    Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms
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