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401“…Chronic lung allograft dysfunction (CLAD) remains a significant challenge and the major determinant of morbidity and mortality post lung transplantation (LTx). …”
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402por Davidsen, Jesper Rømhild, Laursen, Christian B., Højlund, Mikkel, Lund, Thomas Kromann, Jeschke, Klaus Nielsen, Iversen, Martin, Kalhauge, Anna, Bendstrup, Elisabeth, Carlsen, Jørn, Perch, Michael, Henriksen, Daniel Pilsgaard, Schultz, Hans Henrik Lawaetz“…Conclusion: Apical pleural thickening detected by LUS and compatible with PPFE on HRCT separates RAS from BOS in patients with CLAD. We propose LUS as a supplementary tool for initial CLAD phenotyping.…”
Publicado 2021
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403“…Chronic lung allograft dysfunction (CLAD) following lung transplantation limits long-term survival considerably. …”
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404por Courtwright, Andrew M., Lamattina, Anthony M., Takahashi, Mai, Trindade, Anil J., Hunninghake, Gary M., Rosas, Ivan O., Agarwal, Suneet, Raby, Benjamin A., Goldberg, Hilary J., El-Chemaly, Souheil“…Patients with short telomeres and interstitial lung disease may have decreased chronic lung allograft dysfunction (CLAD)-free survival following lung transplantation. …”
Publicado 2020
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405por Sato, Masaaki“…However, recognition of another form of CLAD involving multiple tissue compartments in the lung, termed restrictive allograft syndrome (RAS), raised a fundamental question: why there are two phenotypes of CLAD? …”
Publicado 2020
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406“…Many experiments involving strong coupling make use of metal-clad microcavities, ones with metallic mirrors. Metal-clad microcavities are well-known to support coupled plasmon modes in addition to the standard microcavity mode. …”
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407por Tangaroonsanti, Anupong, Lee, Augustine S, Crowell, Michael D, Vela, Marcelo F, Jones, Daryl R, Erasmus, David, Keller, Cesar, Mallea, Jorge, Alvarez, Francisco, Almansa, Cristina, DeVault, Kenneth R, Houghton, Lesley A“…RESULTS: Esophagogastric junction outflow obstruction alone (EGJOOa) (P=0.01), incomplete bolus transit (IBT) (P=0.006) and proximal reflux (P=0.042) increased the risk for o-CLAD. Patients with EGJOOa were most likely to present with o-CLAD (77%); despite being less likely to exhibit abnormal numbers of reflux events (10%) compared with those with normal motility (o-CLAD: 29%, P<0.05; abnormal reflux events: 64%, P<0.05). …”
Publicado 2017
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408por Rodas, María Isabel Zuluaga, Negrotto, Laura, Deramo, Mariana, Inshasi, Jihad, Boshra, Amir, Youssef, Joseph, De Souza, Sabrina, Cantogno, Elisabetta Verdun Di, Boumenna, Tahani“…BACKGROUND: National Multiple Sclerosis Society and other international guidelines suggest that full COVID-19 vaccination status should be completed two to four weeks before starting Year 2 of treatment with cladribine tablets (CladT). CladT is administered twice over two years, Year 1 and Year 2. …”
Publicado 2023
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409por Sanders, Yan Y.“…More studies and better understanding of cfDNA are needed to develop an accessible and reliable biomarker to monitor the progress of CLAD to improve the long-term survival for lung transplant recipients.…”
Publicado 2020
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410por Young, Katherine A., Ali, Hakim A., Beermann, Kristi J., Reynolds, John M., Snyder, Laurie D.“…Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. …”
Publicado 2021
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411por Ramendra, Rayoun, Fernández-Castillo, Juan C., Huszti, Ella, Ghany, Rasheed, Aversa, Meghan, Havlin, Jan, Riddell, Peter, Chaparro, Cecilia M., Singer, Lianne G., Liu, Louis, Keshavjee, Shaf, Yeung, Jonathan C., Martinu, Tereza“…Associations between oesophageal motility disorders with the development of CLAD and allograft failure (defined as death or re-transplantation) were assessed. …”
Publicado 2023
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412por Brochet, Bruno, Solari, Alessandra, Lechner-Scott, Jeannette, Piehl, Fredrik, Langdon, Dawn, Hupperts, Raymond, Selmaj, Krzysztof, Patti, Francesco, Brieva, Luis, Maida, Eva Maria, Alexandri, Nektaria, Smyk, Andrzej, Nolting, Axel, Keller, Birgit, Montalban, Xavier, Kubala Havrdova, Eva“…Subgroup analyses were performed for participants who were pretreatment-naïve and those pretreated with disease-modifying therapies (DMTs) before initiating CladT. Safety and tolerability of CladT were also assessed. …”
Publicado 2023
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414“…Heated mixtures of FFA with CLAD resulted in complete amorphization of the drug, whereas that with MCC produced a mixture of up to four different polymorphs. …”
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415por Le Pavec, Jérôme, Pradère, Pauline, Gigandon, Anne, Dauriat, Gaëlle, Dureault, Amélie, Aguilar, Claire, Henry, Benoît, Lanternier, Fanny, Savale, Laurent, Dolidon, Samuel, Gazengel, Pierre, Mussot, Sacha, Mercier, Olaf, Husain, Shahid, Lortholary, Olivier, Fadel, Elie“…Our evaluation of de novo IA showed that this infection was most strongly associated with CLAD when found within 4 mo after transplantation.…”
Publicado 2021
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416por Hostetler, Haley P., Neely, Megan L., Kelly, Francine L., Belperio, John A., Budev, Marie, Reynolds, John M., Shah, Pali D., Singer, Lianne G., Snyder, Laurie D., Palmer, Scott M., Todd, Jamie L.“…We previously demonstrated HA accumulates in CLAD after human-lung transplantation. We sought to determine if HA accumulates in the bronchoalveolar lavage fluid (BALF) concurrent with AR in lung recipients. …”
Publicado 2021
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417por Moser, Tobias, Hoepner, Lena, Schwenker, Kerstin, Seiberl, Michael, Feige, Julia, Akgün, Katja, Haschke-Becher, Elisabeth, Ziemssen, Tjalf, Sellner, Johann“…Cladribine (CLAD) is a deoxyadenosine analogue prodrug which is given in multiple sclerosis (MS) as two short oral treatment courses 12 months apart. …”
Publicado 2021
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418por de Zwart, Auke E.S., Riezebos-Brilman, Annelies, Lunter, Gerton A., Neerken, Ewald C.U., van Leer-Buter, Coretta C., Alffenaar, Jan-Willem C., van Gemert, Anna P., Erasmus, Michiel E., Gan, Christiaan T., Kerstjens, Huib A.M., Vonk, Judith M., Verschuuren, Erik A.M“…During social distancing, we found significantly lower odds for any TDLF (OR 0.53 [0.33; 0.85], p=0.008) and severe TDLF (OR 0.34 [0.16; 0.71] p=0.005) as well as lower CLAD incidence (OR 0.53 [0.27; 1.02] p=0.060). Effect modification by RV circulation indicated a significant association between TDLF/CLAD and RVs. …”
Publicado 2022
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419por Erasmus, David Brett, Durand, Nisha, Alvarez, Francisco A, Narula, Tathagat, Hodge, David O, Zubair, Abba C“…Low-dose MSCs appear to slow progression of CLAD in some patients.…”
Publicado 2022
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420por Seiberl, Michael, Feige, Julia, Hilpold, Patrick, Hitzl, Wolfgang, Machegger, Lukas, Buchmann, Arabella, Khalil, Michael, Trinka, Eugen, Harrer, Andrea, Wipfler, Peter, Moser, Tobias“…Data were gathered from a prospective, real-world CLAD cohort. We measured sNfL at baseline (BL-sNfL) and 12 months (12Mo-sNfL) after CLAD start by SIMOA. …”
Publicado 2023
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