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281“…The purpose of this set of data was to evaluate NF-κB gene expression in cecal ligation and puncture (CLP)- induced septic rats and associated hepatic cell changes. …”
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282por Jensen, Camilla, Bæk, Kristoffer T., Gallay, Clement, Thalsø-Madsen, Ida, Xu, Lijuan, Jousselin, Ambre, Ruiz Torrubia, Fernando, Paulander, Wilhelm, Pereira, Ana R., Veening, Jan-Willem, Pinho, Mariana G., Frees, Dorte“…Interestingly, oxacillin antagonized the septum progression defects of clpX cells and prevented lysis of prematurely splitting clpX cells. …”
Publicado 2019
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283por Dominique, Manon, Breton, Jonathan, Guérin, Charlène, Bole-Feysot, Christine, Lambert, Grégory, Déchelotte, Pierre, Fetissov, Sergueï“…Isocaloric amounts of all three macronutrients added to a continuous culture of E. coli increased ClpB immunoreactivity. However, to increase the levels of ClpB mRNA and ClpB protein in bacteria and supernatants, supplementation with protein was required. …”
Publicado 2019
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284por Saito, Motofumi, Sato, Asako, Nagata, Shohei, Tamaki, Satoshi, Tomita, Masaru, Suzuki, Haruo, Kanai, Akio“…Clp1, a polyribonucleotide 5′-hydroxyl kinase in eukaryotes, is involved in pretRNA splicing and mRNA 3′-end formation. …”
Publicado 2019
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285“…First, we show that the protein level of CsrA is temporal during the life cycle and is degraded by ClpP during the TP. The ectopic expression of CsrA in a ΔclpP mutant, but not in the wild type, inhibits both the initiation of the RP in vitro and the invasiveness to Acanthamoeba castellanii, indicating that the ClpP-mediated proteolytic pathway regulates the CsrA protein level. …”
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286“…The role of ClpP varies among tumor types. However, the expression pattern and biological functions of ClpP in breast cancer (BC) have not yet been investigated. …”
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287por Shen, Nengxing, Wei, Wenrui, Chen, Yuhang, Ren, Yongjun, Xiong, Lang, Tao, Yuanyuan, Gu, Xiaobin, Xie, Yue, Peng, Xuerong, Yang, Guangyou“…In this study, after optimizing vaccination schedule, a vaccination trial is comprised of three test groups of rabbits (n = 10/group) by immunization with (1) rSsCLP5; (2) rSsCLP12; or (3) a mixture of rSsCLP5 and rSsCLP12, three biological replicates groups (n = 10/group) and three control groups (n = 10/group). …”
Publicado 2020
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288por Key, Jana, Maletzko, Antonia, Kohli, Aneesha, Gispert, Suzana, Torres-Odio, Sylvia, Wittig, Ilka, Heidler, Juliana, Bárcena, Clea, López-Otín, Carlos, Lei, Yuanjiu, West, A. Phillip, Münch, Christian, Auburger, Georg“…Here, we found that genetic ablation of several mitochondrial matrix factors, such as the peptidase ClpP, the transcription factor Tfam, as well as the peptidase and AAA+ ATPase Lonp1, potently induces Rnf213 transcript expression in various organs, in parallel with other components of the innate immune system. …”
Publicado 2020
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289“…Also, molecular docking showed that RadA protease, ClpP hydrolase, and HtrA protease can potentially interact with PMSF protease inhibitors. …”
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290por Doi, Akiko, Miyazaki, Tomoyuki, Mihara, Takahiro, Ikeda, Maiko, Niikura, Ryo, Andoh, Tomio, Goto, Takahisa“…By contrast, CLP290 alone did not exert sedative effects. Immunohistochemistry showed that midazolam combined with CLP290 decreased the number of phosphorylated cAMP response element-binding protein-positive cells in the cerebral cortex, suggesting that CLP290 reverted the inhibitory effect of midazolam. …”
Publicado 2021
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291por Birk, Marlène S., Ahmed-Begrich, Rina, Tran, Stefan, Elsholz, Alexander K. W., Frese, Christian K., Charpentier, Emmanuelle“…We identified more than 100 putative ClpC target proteins through their stabilization in a clpC deletion strain. …”
Publicado 2021
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292“…This might be the first report on the validity of DNI in preclinical CLP-induced murine sepsis.…”
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293“…The Hsp100 family member ClpB is a protein disaggregase which solubilizes and reactivates stress-induced protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. …”
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294por Greer, Yoshimi Endo, Hernandez, Lidia, Fennell, Emily M.J., Kundu, Manjari, Voeller, Donna, Chari, Raj, Gilbert, Samuel F., Gilbert, Thomas S.K., Ratnayake, Shashikala, Tang, Binwu, Hafner, Markus, Chen, Qingrong, Meerzaman, Daoud, Iwanowicz, Edwin, Annunziata, Christina M., Graves, Lee M., Lipkowitz, Stanley“…SIGNIFICANCE: ClpP agonists disrupt mitochondrial homeostasis by activating mitochondrial matrix protease ClpP. …”
Publicado 2022
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295por Azadmanesh, Jahaun, Seleem, Mohamed A., Struble, Lucas, Wood, Nicholas A., Fisher, Derek J., Lovelace, Jeffrey J., Artigues, Antonio, Fenton, Aron W., Borgstahl, Gloria E.O., Ouellette, Scot P., Conda-Sheridan, Martin“…ClpP functions as a multisubunit proteolytic complex, and bacteria are eradicated when ClpP is disrupted. …”
Publicado 2022
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296por Michaels, Victoria, Chalabi, Smahane, Legrand, Agnes, Renard, Julie, Tejerina, Emmanuel, Daouya, Marina, Fabrega, Sylvie, Megret, Jérôme, Olaso, Robert, Boland, Anne, Deleuze, Jean-François, Battail, Christophe, Tronik-Le Roux, Diana, Ezine, Sophie“…Thus, we in vivo barcoded LMPP and CLP progenitors to test their ability to reconstitute the lymphoid lineage. …”
Publicado 2023
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297por Kakko, Natalia, Rantasalo, Anssi, Koponen, Tino, Vidgren, Virve, Kannisto, Matti, Maiorova, Natalia, Nygren, Heli, Mojzita, Dominik, Penttilä, Merja, Jouhten, Paula“…The ClpXP proteasome was specific to the target proteins, and there was no reduction in the targets when ClpXP was not induced. …”
Publicado 2023
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298por Lu, Xiu-Hong, An, Shi-Qi, Tang, Dong-Jie, McCarthy, Yvonne, Tang, Ji-Liang, Dow, John Maxwell, Ryan, Robert P.“…Nevertheless Clp binding to manA and xag promoters is inhibited by cyclic di-GMP. …”
Publicado 2012
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299por Henderson, Lee W, Dittrich, Howard C, Strickland, Alan, Blok, Thomas M, Newman, Richard, Oliphant, Thomas, Albrecht, Detlef“…BACKGROUND: CLP is an orally administered, non-absorbed, superabsorbent polymer being developed to increase fecal excretion of sodium, potassium and water in patients with heart failure and end-stage renal disease. …”
Publicado 2014
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300por Skirecki, Tomasz, Kawiak, Jerzy, Machaj, Eugeniusz, Pojda, Zygmunt, Wasilewska, Danuta, Czubak, Jarosław, Hoser, Grażyna“…CLP after inhibition of Notch signaling was also performed. …”
Publicado 2015
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