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301por Pulido, Pablo, Llamas, Ernesto, Llorente, Briardo, Ventura, Salvador, Wright, Louwrance P., Rodríguez-Concepción, Manuel“…Genetic evidence indicated that ClpC chaperones might be required for the unfolding of J20-delivered DXS protein coupled to degradation by the Clp protease. …”
Publicado 2016
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303por Xie, Fang, Li, Gang, Zhou, Long, Zhang, Yanhe, Cui, Ning, Liu, Siguo, Wang, Chunlai“…The pigs in the S-8△clpP△apxIIC immunized groups have no lesions and reduced bacterial loads in the lung tissue after challenge. …”
Publicado 2017
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304“…This observation is supported by promoter activity assays, which show that the engXCA expression level is lower when both HpaR1 and Clp are present together, rather than alone. The data also reveal that HpaR1 and Clp activate engXCA gene expression by binding directly to its promoter. …”
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305“…Six partially permissive sites accepting only TGEV-C and three highly permissive sites tolerating A::C or C::A tandem peptide, were identified throughout ClpG. Intact bacteria or extracted CS31A hybrid fibrillae expressing TGEV epitopes at any of the permissive sites, were recognized by Ab directed against the foreign parent protein, providing a direct argument for exposure of the corresponding ClpG region at the cell surface and for antigenicity of the epitopes in the polymeric CS31A fibrillae context. …”
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306por Karimaei, Samira, Kalani, Behrooz Sadeghi, Shahrokhi, Nader, Mashhadi, Rahil, Pourmand, Mohammad Reza“…Here, the expression of TA system genes and ClpP protease was investigated under the thermal and oxidative conditions in S. aureus strains. …”
Publicado 2021
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307por Monaghan, Caitlin E., Adamson, Scott I., Kapur, Mridu, Chuang, Jeffrey H., Ackerman, Susan L.“…Homozygous mutation of the RNA kinase CLP1 (cleavage factor polyribonucleotide kinase subunit 1) causes pontocerebellar hypoplasia type 10 (PCH10), a pediatric neurodegenerative disease. …”
Publicado 2021
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308“…ClpAP, an ATP-dependent protease consisting of ClpA, a double-ring hexameric unfoldase of the ATPases associated with diverse cellular activities superfamily, and the ClpP peptidase, degrades damaged and unneeded proteins to support cellular proteostasis. …”
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309por Wang, Yijie, Zhang, Dapeng, Li, Congxin, Wu, Xue, He, Chen, Zhu, Xiaolin, Zhao, Haiyan, Mu, Lingjie“…The ileal expression of TLR4 was increased by more than five-fold after CLP. CLP significantly increased 7-day mortality and was associated with a higher murine sepsis score (MSS), closely related with increased TLR4 expression. …”
Publicado 2022
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310por Xu, Lijuan, Henriksen, Camilla, Mebus, Viktor, Guérillot, Romain, Petersen, Andreas, Jacques, Nicolas, Jiang, Jhih-Hang, Derks, Rico J. E., Sánchez-López, Elena, Giera, Martin, Leeten, Kirsten, Stinear, Timothy P., Oury, Cécile, Howden, Benjamin P., Peleg, Anton Y., Frees, Dorte“…Super-resolution microscopy demonstrated that inactivation of ClpP reduced binding of daptomycin to the septal site and diminished membrane damage. …”
Publicado 2023
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311por Holbein, Sandra, Scola, Simonetta, Loll, Bernhard, Dichtl, Beatriz Solange, Hübner, Wolfgang, Meinhart, Anton, Dichtl, Bernhard“…Clp1 carries an evolutionarily conserved P-loop motif that was previously shown to bind ATP. …”
Publicado 2011
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312por Gopal, Pooja, Tasneen, Rokeya, Yee, Michelle, Lanoix, Jean-Philippe, Sarathy, Jansy, Rasic, George, Li, Liping, Dartois, Véronique, Nuermberger, Eric, Dick, Thomas“…Infection of mice with panD, clpC1, and mas/ppsA-E mutants showed that whereas growth of clpC1 and mas/ppsA-E mutants was attenuated, the panD mutant grew as well as the wild-type. …”
Publicado 2017
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313por Jensen, Camilla, Fosberg, Marie J., Thalsø-Madsen, Ida, Bæk, Kristoffer T., Frees, Dorte“…In all living cells, molecular chaperones are essential for facilitating folding and unfolding of proteins. ClpX is a highly conserved ATP-dependent chaperone that besides functioning as a classical chaperone can associate with ClpP to form the ClpXP protease. …”
Publicado 2019
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314por Kędzierska-Mieszkowska, Sabina, Potrykus, Katarzyna, Arent, Zbigniew, Krajewska, Joanna“…Here, we characterized the promoter region of the L. interrogans clpB gene (clpB(Li)) encoding an AAA(+) molecular chaperone ClpB essential for the survival of this spirochaete under thermal and oxidative stresses, and also during infection of the host. …”
Publicado 2019
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315“…Interestingly, the expressions of T2SS, T3SS, H2-T6SS, and H3-T6SS were all significantly decreased, while H1-T6SS was increased in the PAO1(ΔclpV3) strain. We also observed that the intracellular concentration of secondary messenger cAMP was reduced in PAO1(ΔclpV3), and the c-di-GMP level was also decreased as indicated by the decreased cdrA reporter activity. …”
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316por Liu, Feng, Xie, Jianfeng, Zhang, Xiwen, Wu, Zongsheng, Zhang, Shi, Xue, Ming, Chen, Jianxiao, Yang, Yi, Qiu, Haibo“…Therefore, this study aimed to evaluate the effects of TGF-β1 overexpressing MSCs on organ injury in cecal ligation and puncture (CLP)-induced septic mice and to detect the changes in macrophage phenotype during this process. …”
Publicado 2020
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317por Maletzko, Antonia, Key, Jana, Wittig, Ilka, Gispert, Suzana, Koepf, Gabriele, Canet-Pons, Júlia, Torres-Odio, Sylvia, West, A. Phillip, Auburger, Georg“…Recent reports showed that also deletion of mitochondrial matrix peptidase ClpP in mice triggers transcriptional upregulation of inflammatory factors. …”
Publicado 2021
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318por Pulido, Pablo, Llamas, Ernesto, Llorente, Briardo, Ventura, Salvador, Wright, Louwrance P., Rodríguez-Concepción, ManuelEnlace del recurso
Publicado 2022
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319por Liu, Feng, Xie, Jianfeng, Zhang, Xiwen, Wu, Zongsheng, Zhang, Shi, Xue, Ming, Chen, Jianxiao, Yang, Yi, Qiu, HaiboEnlace del recurso
Publicado 2022
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320por Luo, Jing, Wang, Jin, Zhang, Jing, Sang, Aming, Ye, Xujun, Cheng, Zhenshun, Li, Xinyi“…Clinical studies showed that the NRF2 mRNA level was inversely correlated with pulmonary inflammation and disease severity in patients with sepsis. Analyses in a CLP-treated Nrf2 knockout mouse model indicated that an Nrf2 deficiency promoted a CLP-induced increase in M1 macrophage polarization and apoptosis and inhibited CLP-induced upregulation of the autophagy level in lung tissues. …”
Publicado 2022
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