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381por Haagdorens, Michel, Cėpla, Vytautas, Melsbach, Eline, Koivusalo, Laura, Skottman, Heli, Griffith, May, Valiokas, Ramūnas, Zakaria, Nadia, Pintelon, Isabel, Tassignon, Marie-José“…METHODS: Human LESC were cultivated on seven different collagen-derived hydrogels: (1) unmodified RHC I, (2) fibronectin-patterned RHC I, (3) carbodiimide-crosslinked CLP (CLP-12 EDC), (4) DMTMM- (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium-) crosslinked CLP (CLP-12), (5) fibronectin-patterned CLP-12, (6) “3D limbal niche-mimicking” CLP-12, and (7) DMTMM-crosslinked CLP made from higher CLP concentration solution. …”
Publicado 2019
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382por Cornelius, Denise C., Travis, Olivia K., Tramel, Robert W., Borges-Rodriguez, Marivee, Baik, Cedar H., Greer, Mallory, Giachelli, Chelsea A., Tardo, Geilda A., Williams, Jan M.“…A subset of CLP rats were treated with MCC950 (50mg/kg/d), a specific NLRP3 inhibitor (CLP+MCC950, n = 10). …”
Publicado 2020
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383por Wang, Jiebo, Liao, Lianming, Chen, Ying, Chen, Liji, Lai, Zhongmeng, Zhang, Liangcheng“…Background: Cecal ligation and perforation (CLP) is currently considered the criterion standard model of sepsis; however, there are some deficiencies, such as low clinical relevance, inconsistency in severity grading, and an unknown proportion of CLP animals meeting the requirements of sepsis-3. …”
Publicado 2023
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384por Taylor, Matthew D., Brewer, Mariana R., Nedeljkovic-Kurepa, Ana, Yang, Yihe, Reddy, Kalpana S., Abraham, Mabel N., Barnes, Betsy J., Deutschman, Clifford S.“…CLP induced changes were not, however, noted following CLP in immune educated mice. …”
Publicado 2020
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385por Green, Benjamin L., Fasaye, Grace-Ann, Samaranayake, Sarah G., Duemler, Anna, Gamble, Lauren A., Davis, Jeremy L.“…There were 22 unique variants in CDH1 among the 29 families that reported CLP, or a CLP rate of 27.5% per variant (22/80). 10 of the variants were not previously reported to be associated with CLP. …”
Publicado 2022
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386por Bedirli, Nurdan, Bagriacik, Emin Umit, Yilmaz, Guldal, Ozkose, Zerrin, Kavutçu, Mustafa, Cavunt Bayraktar, Aslı, Bedirli, Abdulkadir“…OBJECTIVE: We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis. METHODS: Twenty-four rats were assigned to sham, CLP, CLP + sevoflurane, and CLP + isoflurane groups. …”
Publicado 2018
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387por Wu, Jian-Ching, Huang, Chao-Cheng, Wang, Pei-Wen, Chen, Ting-Ya, Hsu, Wen-Ming, Chuang, Jiin-Haur, Chuang, Hui-Ching“…The therapeutic implication of mitochondrial ClpXP protease ClpP and ClpX has been verified in several malignancies, but is unknown in NB. …”
Publicado 2023
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388por Egle, Karina, Skadins, Ingus, Grava, Andra, Micko, Lana, Dubniks, Viktors, Salma, Ilze, Dubnika, Arita“…According to FTIR data, the use of PRF as a carrier for CLP ensured the structural changes in the CLP toward a more active form of clindamycin. …”
Publicado 2022
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389“…The cyclic peptides target the AAA+ protein ClpC1 that, together with the peptidases ClpP1/ClpP2, forms an essential ATP-driven protease. …”
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390por Shinjo, Daisuke, Tachimori, Hisateru, Maruyama-Sakurai, Keiko, Fujimori, Kenji, Inoue, Norihiko, Fushimi, Kiyohide“…Despite evidence of benefits of CLP, basic data and geographic distribution information regarding CLP at the national level remain unclear. …”
Publicado 2021
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391por Li, Xing, Sun, Wen, Li, Jinbo, Wang, Mengmeng, Zhang, Hengwei, Pei, Lingpeng, Boyce, Brendan F., Wang, Zhiyu, Xing, Lianping“…Patients taking antidepressants, including Clomipramine (CLP), have an increased risk of osteoporotic fracture. …”
Publicado 2017
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392por Zhang, Jingyao, Bi, Jianbin, Liu, Sushun, Pang, Qing, Zhang, Ruiyao, Wang, Shun, Liu, Chang“…Meanwhile, the body temperature of mice in the KO-CLP sepsis group was higher than that in the WT-CLP sepsis group and was much closer to the normal body temperature 24 hours after CLP. …”
Publicado 2017
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393por Cornelius, Denise C., Baik, Cedar H., Travis, Olivia K., White, Dakota L., Young, Cassandra M., Austin Pierce, W., Shields, Corbin A., Poudel, Bibek, Williams, Jan M.“…The necrotic cecum was removed at 24 h post‐CLP. At 72 h post‐CLP, activated platelets were significantly increased in CLP versus Sham rats. …”
Publicado 2019
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394“…CLP can appear as unilateral depression or bilateral depression. …”
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395“…METHODS: Mice were randomly assigned to four groups: unoperated control (Normal), sham operation control (Sham), CLP-operation with intravenous injection of phosphate-buffered saline (CLP+PBS), and CLP-operation with rhFNHC-36 treatment (CLP+rhFNHC-36). …”
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396por Dietrich, Alina, Steffens, Ursula, Gajdiss, Mike, Boschert, Anna-Lena, Dröge, Jana Katharina, Szekat, Christiane, Sass, Peter, Malik, Imran T., Bornikoel, Jan, Reinke, Laura, Maček, Boris, Franz-Wachtel, Mirita, Nieselt, Kay, Harbig, Theresa, Scherlach, Kirstin, Brötz-Oesterhelt, Heike, Hertweck, Christian, Sahl, Hans-Georg, Bierbaum, Gabriele“…Genome sequencing of CmR mutants revealed amino acid exchanges in the essential histidine kinase WalK, the Clp protease proteolytic subunit ClpP or the Clp ATPase ClpC, and the heat shock protein DnaK. …”
Publicado 2022
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397por Ma, Ying, Cheng, Zhenshun, Zheng, Yong, Wang, Wei, He, Shaojun, Zhou, Xiaolian, Yang, Jiong, Wei, Chaojie“…Methods: Four hours after cecal ligation and puncture (CLP), Wistar rats were randomized into CLP, CLP + E-5 (esmolol: 5 mg·kg(−1)·h(−1)) and CLP + E-18 (esmolol: 18 mg·kg(−1)·h(−1)) groups. …”
Publicado 2023
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398“…Recent studies reveal that adaptor protein MecA and the protease ClpC act as negative regulators of competence by a mechanism that involves MecA-mediated proteolysis of SigX by the ClpC in S. mutans. …”
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399por Boisramé-Helms, Julie, Meyer, Grégory, Degirmenci, Su Emmanuelle, Burban, Mélanie, Schini-Kerth, Valérie, Cynober, Luc, De Bandt, Jean-Pascal, Hasselmann, Michel, Meziani, Ferhat“…AF and AFA rats required significantly increased norepinephrine infusion rates to reach the mean arterial pressure objective, compared to CLP-HN rats. Both CLP-AF and CLP-AFA reduced mesenteric resistance arterial contractility, decreased vascular oxidative stress, but increased NF-κB (0.40±0.15 in CLP-AF and 0.69±0.06 in CLP-AFA vs. 0.09±0.03 in SHAM rats and 0.30±0.06 in CLP-HN, ß-actin ratio, p<0.05) and pIκB expression (0.60±0.03 in CLP-AF and 0.94±0.15 in CLP-AFA vs. 0.04±0.01 in SHAM rats and 0.56±0.07 in CLP-HN, ß-actin ratio, p<0.05), nitric oxide and prostacyclin production in septic rats. …”
Publicado 2016
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400“…The mycobacterial caseinolytic protease ClpP1P2 is a degradative protease that recently gained interest as a genetically and pharmacologically validated drug target for tuberculosis. …”
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