Mostrando 61 - 80 Resultados de 2,845 Para Buscar '"CLP"', tiempo de consulta: 0.45s Limitar resultados
  1. 61
    “…The ring-shaped hexamers of ClpB unfold and thread its protein substrate through the central pore. …”
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    Dynamic structural states of ClpB involved in its disaggregation function
  2. 62
    “…Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve critical functions in proteostasis by solubilizing protein aggregates. …”
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    Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
  3. 63
    “…ClpG co-exists with ClpB in selected bacteria and provides superior heat resistance. …”
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    ClpG Provides Increased Heat Resistance by Acting as Superior Disaggregase
  4. 64
    “…In vitro, MinC and MinD are known to coassemble into linear polymers; therefore, we monitored copolymers assembled in vitro after incubation with ClpXP and observed that ClpXP promotes rapid MinCD copolymer destabilization and direct MinD degradation by ClpXP. …”
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    Degradation of MinD oscillator complexes by Escherichia coli ClpXP
  5. 65
    “…Moreover, sulfur metabolism-associated proteins were potential substrates of ClpP and were upregulated by MG treatment in wild-type R. solanacearum but not in clpP mutant. …”
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    Bacterial ClpP Protease Is a Potential Target for Methyl Gallate
  6. 66
    “…Together, these characteristics highlight the multifunctional roles of Clp in L. enzymogenes, a powerful bacterial warrior against fungal pathogens.…”
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    Clp is a “busy” transcription factor in the bacterial warrior, Lysobacter enzymogenes
  7. 67
    “…CLP1, TSEN complex, and VCP are evolutionarily conserved proteins whose mutations are associated with neurodegenerative diseases. …”
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    RNA kinase CLP1/Cbc regulates meiosis initiation in spermatogenesis
  8. 68
    por Pandey, Satya D., Biswas, Indranil
    Publicado 2022
    “…While the exact reason for this differential effect of ClpP and ClpX on transformation is currently unknown, we found that both ClpC and ClpE have a negative effect on transformation, which was not reported before.…”
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    Clp ATPases differentially affect natural competence development in Streptococcus mutans
  9. 69
    “…We have determined the structure of a ternary complex of Clp1 together with ATP and the Clp1-binding region of Pcf11. …”
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    Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor
  10. 70
    “…This response includes chaperones and proteases, as well as the transcription factor Rv2745c, which we characterize as a Clp protease gene regulator (ClgR) orthologue. During reaeration, genes repressed during hypoxia are also upregulated in a wave of transcription that includes genes crucial to transcription, translation and oxidative phosphorylation and culminates in bacterial replication. …”
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    Characterization of a Clp Protease Gene Regulator and the Reaeration Response in Mycobacterium tuberculosis
  11. 71
    “…ATP-dependent Clp protease (ClpP) is a core unit of a major bacterial protease complex employing as a new attractive drug target for that isolates, which are resistant to antibiotics. …”
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    A ClpP protein model as tuberculosis target for screening marine compounds
  12. 72
    “…To investigate the role of ClpP in the virulence of A. pleuropneumoniae, the clpP gene was deleted by homologous recombination, resulting in the mutant strain S8ΔclpP. …”
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    The ClpP Protease Is Required for the Stress Tolerance and Biofilm Formation in Actinobacillus pleuropneumoniae
  13. 73
    “…EhClpB forms ATP-dependent oligomers and catalyzes the ATP hydrolysis, similar to E. coli ClpB (EcClpB), but its ATPase activity is insensitive to the EcClpB activators, casein and poly-lysine. …”
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    Aggregate-Reactivation Activity of the Molecular Chaperone ClpB from Ehrlichia chaffeensis
  14. 74
    “…Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. …”
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    Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis
  15. 75
    “…Furthermore, we show that propagation requires the disaggregase activity of the ClpB chaperone. Prion propagation in yeast requires Hsp104 (a ClpB ortholog), and prior studies have come to conflicting conclusions about ClpB's ability to participate in this process. …”
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    Prion propagation can occur in a prokaryote and requires the ClpB chaperone
  16. 76
    “…We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB. TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS. …”
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    TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB
  17. 77
    “…The hexameric AAA+ ring of Escherichia. coli ClpX, an ATP-dependent protein unfolding and translocation machine, functions with the ClpP peptidase to degrade target substrates. …”
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    Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX
  18. 78
    “…The aim was to verify that dexmedetomidine (DEX) can attenuate CLP-induced intestinal injury via inhibition of inflammation. …”
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    Dexmedetomidine Ameliorate CLP-Induced Rat Intestinal Injury via Inhibition of Inflammation
  19. 79
    “…Knockdown of ClpXP subunits ClpP or ClpX induces the accumulation of misfolded SDHB, impairing oxidative phosphorylation and ATP production while activating “stress” signals of 5′ adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and autophagy. …”
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    The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis
  20. 80
    “…Unexpectedly, the presence of E. coli DnaK/DnaJ/GrpE did not significantly affect the disaggregation activity of ClpB(Li) and ClpB(Li) did not substitute for the ClpB(Ec) function in the clpB-null E. coli strain. …”
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    Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans
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