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801por Mohtasham, Nooshin, Shahabinejad, Mehdi, Kafiroudi, Somayeh, Mohajertehran, Farnaz“…MATERIALS AND METHODS: Paraffin blocks of LP lesions including 56 OLP and 56 CLP samples were selected from theMashhad University of Medical sciences, Mashhad, Iran. …”
Publicado 2021
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802por Cao, Zhenzhen, Qin, Hongqian, Huang, Yuhui, Zhao, Yingxue, Chen, Zhipeng, Hu, Junfeng, Gao, Qin“…These adverse effects of CLP were relieved by Alda-1, Fer-1, and MCC950 treatment. …”
Publicado 2022
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803por Xu, Lei, Li, Ran, Li, Juan, Dong, Zhou, Zong, Jiaxin, Tan, Chuchu, Ye, Zekang, Shi, Lu, Gong, Xiaoxuan, Li, Chunjian“…This study aimed to explore an efficient method to simultaneously determine the plasma clopidogrel, 2-oxo-clopidogrel (2-Oxo-CLP), and the clopidogrel active metabolite (CAM). …”
Publicado 2022
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804“…Cecal ligation and puncture (CLP) was used to establish the sepsis-related neurodamage animal models. …”
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805“…MATERIALS AND METHODS: Sprague-Dawley rats were assigned into Sham, caecal ligation and puncture (CLP), CLP + Lav (200, 400, and 800 mg/kg) groups. …”
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806“…Six hours after CLP, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and intercellular adhesion molecule-1 (ICAM-1) levels were analyzed in blood samples. …”
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807“…One such target is the ATP-dependent protease ClpC1P1P2, which is strictly essential for viability. …”
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808por Pan, Huibin, Huo, Lixia, Shen, Weiyun, Dai, Zhuquan, Bao, Ying, Ji, Chaohui, Zhang, Jie“…The abundance of gut microbiota in CLP rats was significantly different from that of the sham and BBR treatment rats. …”
Publicado 2022
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809por de Souza Costa, Maria Fernanda, Bastos Trigo de Negreiros, Catarina, Ugarte Bornstein, Victor, Hemmi Valente, Richard, Mengel, José, Henriques, Maria das Graças, Farias Benjamim, Claudia, Penido, Carmen“…RESULTS: Severe sepsis induced by CLP in C57BL/6 mice led to an intense lung inflammatory response, marked by the accumulation of γδ T lymphocytes (comprising the Vγ4 subtype). γδ T lymphocytes present in the lungs of CLP mice were likely to be originated from peripheral lymphoid organs and migrated towards CCL2, CCL3 and CCL5, which were highly produced in response to CLP-induced sepsis. …”
Publicado 2015
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810“…RESULTS: Compared to sham mice, CLP-sepsis resulted in pulmonary microvascular barrier dysfunction, quantified by increased EB-albumin leak, and PMVEC death (PI+ staining) as early as 2 h and more marked by 4 h after CLP. …”
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811por Selmi, Valentina, Loriga, Beatrice, Vitali, Luca, Carlucci, Martina, Di Filippo, Alessandro, Carta, Giulio, Sgambati, Eleonora, Tofani, Lorenzo, De Gaudio, Angelo Raffaele, Novelli, Andrea, Adembri, Chiara“…Sepsis was induced by cecal ligation and puncture (CLP). Rats were divided into two groups: Sham-operated and CLP. …”
Publicado 2016
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812por Smirnov, Anna, Pohlmann, Stephanie, Nehring, Melanie, Ali, Shafaqat, Mann-Nüttel, Ritu, Scheu, Stefanie, Antoni, Anne-Charlotte, Hansen, Wiebke, Büettner, Manuela, Gardiasch, Miriam J., Westendorf, Astrid M., Wirsdörfer, Florian, Pastille, Eva, Dudda, Marcel, Flohé, Stefanie B.“…From 24 h on after CLP, BMC gave rise to BMDC that released enhanced levels of IL-10. …”
Publicado 2017
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813“…The effects of SB203580 on CLP-induced septic ALI model rats were similar to those of taurine. …”
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814por Makjaroen, Jiradej, Thim-Uam, Arthid, Dang, Cong Phi, Pisitkun, Trairak, Somparn, Poorichaya, Leelahavanichkul, Asada“…BACKGROUND: Because survival and death after sepsis are partly due to a proper immune adaptation and immune dysregulation, respectively, survivors and moribund mice after cecal ligation and puncture (CLP) sepsis surgery and in vitro macrophage experiments were explored. …”
Publicado 2021
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815por Mueen, Ruaa Murtada, Al-Juaifari, Maytham, Abosaooda, Munther, Qassam, Heider, Hadi, Najah Rayish“…Twenty-four adult male Swiss-albino mice, aged 8-12 weeks and weighing 20-30 g, were divided into four equal groups (n=6): sham (laparotomy only), CLP (laparotomy plus cecal ligation and puncture), vehicle (DMSO administered one hour before CLP), and Ticagrelor (50 mg/kg IP administered one hour before CLP). …”
Publicado 2023
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816por Zhu, Weimin, Bao, Rui, Fan, Xiaohua, Tao, Tianzhu, Zhu, Jiali, Wang, Jiafeng, Li, Jinbao, Bo, Lulong, Deng, Xiaoming“…Anti-PD-L1 antibody significantly alleviated the morphology of liver injury in CLP mice. Anti-PD-L1 antibody administration decreased ALT and AST release in CLP mice, decreased the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 mRNA in liver after sepsis challenge. …”
Publicado 2013
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817por Ito, Fumihiro, Tamiya, Takayuki, Ohtsu, Iwao, Fujimura, Makoto, Fukumori, Fumiyasu“…The KTΔclpB mutant showed the same heat shock response (HSR) as the wild-type, both in terms of heat-shock protein (Hsp) synthesis (other than ClpB) and in hsp gene expression; however, the mutant was quite sensitive to high temperatures and was unable to disaggregate into thermo-mediated protein aggregates, indicating that ClpB is important for cell survival after heat stress and essential for solubilization of protein aggregates. …”
Publicado 2014
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818“…Here, we report the isolation and characterization of two novel mutations in rpoB gene capable of modulating the expression of cps genes in Δlon strains of E. coli in concert with HNS. clpA, clpB, clpY, and clpQ mutations do not affect this capsule expression suppressor (Ces) phenotype. …”
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819por He, Ran, Shen, Nengxing, Zhang, Haojie, Ren, Yongjun, He, Manli, Xu, Jing, Guo, Cheng, Xie, Yue, Gu, Xiaobin, Lai, Weimin, Peng, Xuerong, Yang, Guangyou“…Indirect ELISA using recombinant SsCLP (rSsCLP) exhibited diagnostic sensitivity of 94.4% (17/18) and specificity of 86.7% (26/30). …”
Publicado 2017
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820por Calvier, Elisa A. M., Krekels, Elke H. J., Yu, Huixin, Välitalo, Pyry A. J., Johnson, Trevor N., Rostami‐Hodjegan, Amin, Tibboel, Dick, van der Graaf, Piet H., Danhof, Meindert, Knibbe, Catherijne A. J.“…For scaling drug plasma clearance (CLp) from adults to children, extrapolations of population pharmacokinetic (PopPK) covariate models between drugs sharing an elimination pathway have enabled accelerated development of pediatric models and dosing recommendations. …”
Publicado 2018
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