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821por Nullens, Sara, De Man, Joris, Bridts, Chris, Ebo, Didier, Francque, Sven, De Winter, Benedicte“…We therefore characterized in detail the gastrointestinal neuroimmune environment in the cecal ligation and puncture (CLP) model, which is the gold standard animal model of microbial sepsis. …”
Publicado 2018
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822por Wang, Xunming, Cai, Diwen, Sun, Jimin, Lu, Huayu, Liu, Wenbin, Qiang, Mingrui, Cheng, Hong, Che, Huizheng, Hua, Ting, Zhang, Caixia“…Results indicated it would take an average theoretical time of 80.8 ka and 4,475.9 ka to form the current dimensions of the BJD and CLP, respectively, which means the Gobi Desert may provide substantial sand sources to the modern BJD, while its contribution to the loess of modern CLP might be overestimated despite it was the key sources of the CLP in Quaternary.…”
Publicado 2019
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823por Stachyra, Anna, Zawistowska-Deniziak, Anna, Basałaj, Katarzyna, Grzelak, Sylwia, Gondek, Michał, Bień-Kalinowska, Justyna“…The present study uses the Pichia pastoris expression system to produce a soluble TbCLP antigen which induces strong antibody responses in the host during natural infection. …”
Publicado 2019
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824por Zhang, Hai-feng, Zhang, Hai-bo, Wu, Xue-ping, Guo, Ya-ling, Cheng, Wei-dong, Qian, Feng“…In this study we investigated whether fisetin exerted a protective effect against sepsis-induced multiple organ dysfunction in mouse cecum ligation and puncture (CLP) model. The mice were injected with fisetin (10 mg/kg, ip) 0.5 h prior to CLP, and sacrificed 18 h after CLP. …”
Publicado 2020
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825“…In both LPS-treated human umbilical vein endothelial cells (HUVECs) and the CLP-treated mouse model of sepsis, we applied CN after the induction processes were over. …”
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826por Zhao, Lin, Zhao, Huadong, Sun, Meng, Chen, Mengfan, Wu, Xue, Deng, Chao, Yang, Wenwen, Tian, Ye, Wang, Qibing, Liang, Zhenxing, Xu, Xuezeng, Yang, Yang“…In this study, the therapeutic effects of KCD were evaluated in the cecal ligation and puncture (CLP) model of BALB/c mice. The effects of KCD on cardiac function, myocardium damage, inflammation, and fibrosis in CLP-injured mice were analyzed with echocardiography, histological staining, and quantitative real-time PCR. …”
Publicado 2022
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827por Chancharoenthana, Wiwat, Sutnu, Nattawut, Visitchanakun, Peerapat, Sawaswong, Vorthon, Chitcharoen, Suwalak, Payungporn, Sunchai, Schuetz, Alexandra, Schultz, Marcus J., Leelahavanichkul, Asada“…There was no difference in the fungal microbiome (predominant Ascomycota in both sham and CLP mice) and the abundance of all organisms between sepsis and control groups. …”
Publicado 2022
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828“…Our results indicated that S100A8/A9 expression was significantly upregulated in the livers of septic mice 24 h after cecal ligation and a puncture (CLP) operation. Moreover, S100A9-KO in mice markedly attenuated CLP-induced liver dysfunction and injury, promoting the AMPK/ACC/GLUT4-mediated increases in fatty acid and glucose uptake as well as the improvement in mitochondrial function and ATP production. …”
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829por Xie, Tingbin, Lv, Tengfei, Zhang, Tenghui, Feng, Dengyu, Zhu, Feng, Xu, Yi, Zhang, Liang, Gu, Lili, Guo, Zhen, Ding, Chao, Gong, Jianfeng“…CLP + IgG, P < 0.001; +30.72% vs. LPS + IgG, P < 0.001). …”
Publicado 2023
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830“…Each methanol O atom is hydrogen bonded to one O atom and two N—H groups in the same CLP-A molecule. There are a total of eight hydrogen bonds in each CLP-A–MeOH unit.…”
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831por Yang, Fen, Xia, Ni, Guo, Shuang, Zhang, Jiyu, Liao, Yuhan, Tang, Tingting, Nie, Shaofang, Zhang, Min, Lv, Bingjie, Lu, Yuzhi, Jiao, Jiao, Li, Jingyong, Wang, Weimin, Hu, Desheng, Cheng, Xiang“…Here, the authors revealed the protective effect of SCFAs on AAA in mice and the expansion of Tregs in the cLP, and propionate exerted Treg-dependent protection against AAA by promoting the recirculation of cLP-Tregs through colonic draining lymph nodes (dLNs) to the inflamed aorta.…”
Publicado 2022
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832por Wan, Youdong, Wang, Shuya, Niu, Yifan, Duo, Boyang, Liu, Yinshuang, Lu, Zhenzhen, Zhu, Ruixue“…METHODS: Aged 20-21 months SD rats were categorized into three groups: sham-operated rats (AgS group), rats with cecal ligation and puncture (CLP)-induced sepsis (AgCLP group), and rats treated with metformin (100 mg/kg) orally 1 h after CLP treatment (AgMET group). …”
Publicado 2023
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833por Vanderhaeghen, Tineke, Timmermans, Steven, Eggermont, Melanie, Watts, Deepika, Vandewalle, Jolien, Wallaeys, Charlotte, Nuyttens, Louise, De Temmerman, Joyca, Hochepied, Tino, Dewaele, Sylviane, Berghe, Joke Vanden, Sanders, Niek, Wielockx, Ben, Beyaert, Rudi, Libert, Claude“…Hydrodynamic injection of an HRE-luciferase reporter plasmid also led to (liver-specific) signals in hypoxia and CLP. Despite these encouraging data, however, hepatocyte-specific HIF1α and/or HIF2α knock-out mice suggest that survival after CLP was not dependent on the hepatocyte-specific presence of HIF proteins, which was supported by measuring blood levels of glucose, FFAs, and KBs. …”
Publicado 2023
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834“…MATERIALS AND METHODS: Thirty C57BL/6 male mice were adaptive fed for three days and used to establish acute sepsis model by caecal ligation and perforation (CLP). These experimental mice were divided into Sham, CLP, CLP + 25 mg PMS/kg body weight (PMS/kg), CLP + 50 mg PMS/kg and CLP + 100 mg PMS/kg (n = 6). …”
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835por Chang, Chia-Lo, Leu, Steve, Sung, Hsin-Ching, Zhen, Yen-Yi, Cho, Chung-Lung, Chen, Angela, Tsai, Tzu-Hsien, Chung, Sheng-Ying, Chai, Han-Tan, Sun, Cheuk-Kwan, Yen, Chia-Hung, Yip, Hon-Kan“…BACKGROUND: We tested whether apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) were superior to healthy (H)-ADMSCs at attenuating organ damage and mortality in sepsis syndrome following cecal ligation and puncture (CLP). METHODS: Adult male rats were categorized into group 1 (sham control), group 2 (CLP), group 3 [CLP + H-ADMSC administered 0.5, 6, and 18 h after CLP], group 4 [CLP + A-ADMSC administered as per group 3]. …”
Publicado 2012
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836por Watanabe, Yoshio, Singamsetty, Srikanth, Zou, Baobo, Guo, Lanping, Stefanovski, Darko, Alonso, Laura C., Garcia-Ocana, Adolfo, O’Donnell, Christopher P., McVerry, Bryan J.“…We next extended our findings using a cecal ligation and puncture (CLP) sepsis model administered early parenteral glucose support. …”
Publicado 2013
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837por Wilson, Joel, Higgins, David, Hutting, Haley, Serkova, Natalie, Baird, Christine, Khailova, Ludmila, Queensland, Kelly, Vu Tran, Zung, Weitzel, Lindsay, Wischmeyer, Paul E“…RESULTS: Seven days following CLP, propranolol improved survival versus control (P < 0.01). …”
Publicado 2013
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838“…METHODS: Septic rat models were established by cecal ligation and puncture (CLP). Rats were divided into the sham group, the CLP group, and the CLP+ 8-bromo-cyclic adenosine diphosphate ribose (8-Br-cADPR) group. …”
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839por Sjaastad, Frances V., Condotta, Stephanie A., Kotov, Jessica A., Pape, Kathryn A., Dail, Cody, Danahy, Derek B., Kucaba, Tamara A., Tygrett, Lorraine T., Murphy, Katherine A., Cabrera-Perez, Javier, Waldschmidt, Thomas J., Badovinac, Vladimir P., Griffith, Thomas S.“…Using the cecal ligation and puncture (CLP) mouse model of sepsis induction, we observed reduced antibody production in mice challenged with influenza A virus or TNP-KLH in alum early (2 days) and late (30 days) after CLP surgery compared to mice subjected to sham surgery. …”
Publicado 2018
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840por Bitzinger, Diane I., Gruber, Michael, Tümmler, Simon, Malsy, Manuela, Seyfried, Timo, Weber, Florian, Redel, Andreas, Graf, Bernhard M., Zausig, York A.“…METHODS: Sham surgery or CLP was performed in male Wistar rats (n = 60). …”
Publicado 2019
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