Mostrando 81 - 100 Resultados de 2,845 Para Buscar '"CLP"', tiempo de consulta: 0.16s Limitar resultados
  1. 81
    “…Moreover, tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration. …”
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    Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced Septic Mice
  2. 82
    “…Clp-defective fruit displayed aberrant chromoplasts and up-regulated expression of nuclear genes encoding the tomato homologs of Orange (OR) and ClpB3 chaperones, most probably to deal with misfolded and aggregated proteins that could not be degraded by the Clp protease. …”
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    Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening
  3. 83
    “…The chaperone ClpB in bacteria is responsible for the reactivation of aggregated proteins in collaboration with the DnaK system. …”
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    Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate
  4. 84
    “…The protein disaggregase ClpB hexamer is conserved across evolution and has two AAA+-type nucleotide-binding domains, NBD1 and NBD2, in each protomer. …”
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    ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB
  5. 85
    “…ClpC1 is an emerging new target for the treatment of Mycobacterium tuberculosis infections, and several cyclic peptides (ecumicin, cyclomarin A, and lassomycin) are known to act on this target. …”
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    Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus
  6. 86
    “…We previously discovered that the mitochondrial AAA+ protein unfoldase ClpX (mtClpX) activates the initiating enzyme for heme biosynthesis, 5-aminolevulinic acid synthase (ALAS), by promoting cofactor incorporation. …”
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    Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding
  7. 87
    “…ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and translocates specific protein substrates into the degradation chamber of ClpP. …”
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    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
  8. 88
    “…METHOD: The chemical risk assessment was conducted using a modified INRS method, according to the new CLP Regulation, of 11 unit laboratories in a Moroccan medical laboratory. …”
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    Assessment of Chemical Risks in Moroccan Medical Biology Laboratories in Accordance with the CLP Regulation
  9. 89
    “…Herein, we found a homolog of ClpB from Corynebacterium crenatum. The amino acid sequence of ClpB was analyzed, and the recombinant ClpB protein was purified and characterized. …”
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    Role of ClpB From Corynebacterium crenatum in Thermal Stress and Arginine Fermentation
  10. 90
    “…All isolates carried mutations in clpP. All mutated S. aureus ClpP proteins characterised in this study were functionally impaired; this increased our understanding of the mode of operation of ClpP. …”
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    Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes
  11. 91
    “…In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the C-terminus of the incomplete protein, which directs degradation by the AAA+ ClpXP protease. Here, we present cryo-EM structures of ClpXP bound to the ssrA degron. …”
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    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
  12. 92
    “…A functional association is uncovered between the ribosome-associated trigger factor (TF) chaperone and the ClpXP degradation complex. Bioinformatic analyses demonstrate conservation of the close proximity of tig, the gene coding for TF, and genes coding for ClpXP, suggesting a functional interaction. …”
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    Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
  13. 93
    “…Proteolysis by ClpP1P2 requires an associated ATPase, either ClpX or ClpC1. …”
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    ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria
  14. 94
    “…METHODS: In our study, we investigated the protective mechanisms of cangrelor in CLP-induced pulmonary injury in sepsis, using C57BL/6 mouse models. …”
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    Cangrelor ameliorates CLP-induced pulmonary injury in sepsis by inhibiting GPR17
  15. 95
    “…In the present study, the therapeutic effect of thymoquinone (TQ) on the expression of sepsis-related microRNAs (miRNAs/miRs), levels of inflammatory markers, organ dysfunction and mortality were investigated in a cecal ligation and puncture (CLP) rat model. A single dose of TQ (1 mg/kg) was administered to animals 24 h after CLP and the mortality rate was assessed up to 7 days following the induction of sepsis. …”
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    Thymoquinone modulates the expression of sepsis-related microRNAs in a CLP model
  16. 96
    “…We also compared substitution patterns between pairs of Clp core paralogs to gain insight into post-duplication evolutionary routes. …”
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    Gene duplication and rate variation in the evolution of plastid ACCase and Clp genes in angiosperms
  17. 97
    “…[Image: see text] ClpXP complex is an ATP-dependent mitochondrial matrix protease that binds, unfolds, translocates, and subsequently degrades specific protein substrates. …”
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    Intrinsic Dynamics of the ClpXP Proteolytic Machine Using Elastic Network Models
  18. 98
    “…As a proof of concept, we simulated the prediction of a candidate gene for the recently cloned variegation mutant albostrians (HvAST/HvCMF7) and adopted the approach for suggesting HvClpC1 as candidate gene for the yellow-green variegation mutant luteostrians.…”
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    ATP-Dependent Clp Protease Subunit C1, HvClpC1, Is a Strong Candidate Gene for Barley Variegation Mutant luteostrians as Revealed by Genetic Mapping and Genomic Re-sequencing
  19. 99
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    Protective effect of HDACIs in improves survival and organ injury after CLP-induced sepsis
  20. 100
    “…Recently, ClpP agonists have emerged as a novel class of mitochondria-targeting drugs. …”
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    Targeting Mitochondria with ClpP Agonists as a Novel Therapeutic Opportunity in Breast Cancer
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