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1021“…Results. A cleft of the lip in CLP patients is more likely to be complete in males. …”
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1022por Hayes, Polly, Varga, Vladimir, Olego-Fernandez, Sofia, Sunter, Jack, Ginger, Michael L., Gull, Keith“…ClpGM6 is a cytoskeletal protein located within the flagellum along the flagellar attachment zone (FAZ). …”
Publicado 2014
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1023“…Mice were assigned to one normal control group (NC) and two sepsis groups that were induced by cecal ligation and puncture (CLP). One of the sepsis groups was injected with saline (SS), whereas the other (SA) was administered with a single bolus of 300 mg Arg/kg body weight via the tail vein 1 h after CLP. …”
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1024“…BACKGROUND: Orofacial clefts include cleft lip only (CLO), cleft palate only (CPO), and cleft lip with palate (CLP). Previously, we reported the expression profile of plasma microRNAs in CLO, CPO, and CLP, respectively. …”
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1025por Piliponsky, Adrian M., Shubin, Nicholas J., Lahiri, Asha K., Truong, Phuong, Clauson, Morgan, Niino, Kerri, Tsuha, Avery L., Nedospasov, Sergei A., Karasuyama, Hajime, Reber, Laurent L., Tsai, Mindy, Mukai, Kaori, Galli, Stephen J.“…Here, we demonstrate that basophil-deficient mice exhibited reduced bacterial clearance, and increased morbidity and mortality, in the cecal ligation and puncture (CLP) model of sepsis. Among the several pro-inflammatory mediators we measured, tumor necrosis factor (TNF) was the only cytokine that was significantly reduced in basophil-deficient mice after CLP. …”
Publicado 2019
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1026“…ClpX grips large hydrophobic and aromatic side chains strongly and small, polar, or charged side chains weakly. …”
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1027por Wamp, Sabrina, Rutter, Zoe J, Rismondo, Jeanine, Jennings, Claire E, Möller, Lars, Lewis, Richard J, Halbedel, Sven“…We also identify ReoY as a second novel factor required for degradation of ClpCP substrates. Collectively, our data imply that the first committed step of PG biosynthesis is activated through control of ClpCP protease activity in response to signals of PG homeostasis imbalance.…”
Publicado 2020
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1028“…These findings suggest that Italian CLP children and adolescents experience a poorer OHRQoL in comparison to their non-cleft peers.…”
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1029Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsispor Cuccurullo, Alessandra, Greco, Elisabetta, Lupia, Enrico, De Giuli, Paolo, Bosco, Ornella, Martin-Conte, Erica, Spatola, Tiziana, Turco, Emilia, Montrucchio, Giuseppe“…METHODS: We synthesized a chimeric protein able to inhibit TPO, mTPOR-MBP, and studied its effect in two murine experimental models, acute endotoxemia and cecal ligation and puncture (CLP) model. RESULTS: In both models, TPO levels markedly increased, from 289.80±27.87 pg/mL to 465.60±45.92 pg/mL at 3 hours in the LPS model (P<0.01), and from 265.00±26.02 pg/mL to 373.70±26.20 pg/mL in the CLP model (P<0.05), respectively. …”
Publicado 2016
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1030por Zhou, Xiaofeng, Ji, Chunya, Sun, Lingling, Yin, Linliang, Deng, Xuedong, Pan, Qi, Zhang, Jun, Yang, Zhong, Zheng, Chenhan, Ling, Chen, Shi, Liping, Wu, Yanqing“…The abnormal MNM angle and FS distance could be used as sensitive indicators for CLP. However, PL distance was not the best markers for trisomy 21, trisomy 18 and CLP. …”
Publicado 2022
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1031por Yang, Weng-Lang, Sharma, Archna, Zhang, Fangming, Matsuo, Shingo, Wang, Zhimin, Wang, Haichao, Wang, Ping“…For the induction of sepsis, male C57BL/6 mice (20–25 g) were subjected to cecal ligation and puncture (CLP). Peptide MSP68 (1 mg/kg body weight) or normal saline (vehicle) was injected intravenously at 2 h after CLP. …”
Publicado 2015
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1032por Pan, Shangwen, Wu, Yan, Pei, Lei, Li, Shengnan, Song, Limin, Xia, Haifa, Wang, Yaxin, Yu, Yuan, Yang, Xiaobo, Shu, Huaqing, Zhang, Jiancheng, Yuan, Shiying, Shang, You“…Male C57BL/6J mice were subjected to cecal ligation and puncture (CLP) or a sham operation. BML-111 was administered via intracerebroventricular injection (0.1 mg/kg) immediately after CLP. …”
Publicado 2018
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1033por Yin, Jialin, Shen, Yanan, Si, Yanna, Zhang, Yuan, Du, Jiayue, Hu, Xiajuan, Cai, Mengmeng, Bao, Hongguang, Xing, Yan“…METHODS: Sepsis was induced in adult C57BL/6 J male mice by cecal ligation and perforation (CLP) surgery. Randomly selected CLP mice were transfected with short interfering RNAs (siRNAs) against SOX2OT or SOX2, or with scrambled control siRNA. …”
Publicado 2020
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1034“…BACKGROUND: Collaboration among different categories of health professionals is essential for quality patient care, especially for individuals with cleft lip and palate (CLP). This study examined interprofessional collaboration (IPC) among health professionals in all CLP specialised centres in South Africa’s public health sector. …”
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1035por Cummings, Jessica, Wu, Yijen L., Dixon, C. Edward, Henchir, Jeremy, Simard, J. Marc, Panigrahy, Ashok, Kochanek, Patrick M., Jha, Ruchira M., Aneja, Rajesh K.“…Therefore, we hypothesized that knockout (KO) of Abcc8 (Sur1 gene) is associated with a decrease in microglial activation, cerebral edema, and improved neurobehavioral outcomes in a murine cecal ligation and puncture (CLP) model of sepsis. Sepsis was induced in 4–6-week-old Abcc8 KO and wild-type (WT) littermate control male mice by CLP. …”
Publicado 2023
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1036por Tsoporis, James N., Amatullah, Hajera, Gupta, Sahil, Izhar, Shehla, Ektesabi, Amin M., Vaswani, Chirag M., Desjardins, Jean-Francois, Kabir, Golam, Teixera Monteiro, Ana Paula, Varkouhi, Amir K., Kavantzas, Nikolaos, Salpeas, Vasileios, Rizos, Ioannis, Marshall, John C., Parker, Thomas G., Leong-Poi, Howard, dos Santos, Claudia C.“…Here we compared wildtype (WT) with DJ-1 deficient mice at 24 and 48 h after cecal ligation and puncture (CLP). In WT mice, DJ-1 was increased in the myocardium post-CLP. …”
Publicado 2023
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1037por Star, Bastiaan S., van der Slikke, Elisabeth C., van Buiten, Azuwerus, Henning, Robert H., Bouma, Hjalmar R.“…In addition, SUL-138 mitigated the CLP-induced increase in kidney dysfunction markers NGAL and urea. …”
Publicado 2023
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1038por Su, Jingqian, Chen, Siyuan, Xiao, Jianbin, Feng, Zhihua, Hu, Shan, Su, Qiaofen, Chen, Qi, Chen, Duo“…This study demonstrates the potential benefits of AE in the treatment of CLP-induced sepsis and investigates its underlying mechanism, along with the efficacy of postoperative AE treatment in mice with CLP-induced sepsis. …”
Publicado 2023
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1039por Tuon, Lisiane, Comim, Clarissa M, Petronilho, Fabrícia, Barichello, Tatiana, Izquierdo, Ivan, Quevedo, João, Dal-Pizzol, Felipe“…METHODS: The rats underwent cecal ligation and perforation (CLP) (sepsis group) with 'basic support' (saline at 50 mL/kg immediately and 12 hours after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 hours after CLP) or sham-operated (control group). …”
Publicado 2008
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1040“…Heme oxygenase (HO)-1 counteracts CLP-mediated septic shock in mouse models. In HO-1-deficient mice, LD formation was not observed upon CLP, but a concomitant decrease in “LD-decorating proteins” was observed, implying a link between LDs and cytoprotective activity. …”
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