Mostrando 121 - 140 Resultados de 2,845 Para Buscar '"CLP"', tiempo de consulta: 0.19s Limitar resultados
  1. 121
    “…Caseinolytic protease (ClpP) is a tetradecameric complex, which has emerged as a drug target against multiple pathogenic bacteria. …”
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    Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
  2. 122
    “…Hence, we speculate that docking to ClpX may trigger release of its substrate through activation of a “closed” state (as seen in the RssB-IraD complex), thereby coupling adaptor docking (to ClpX) with substrate release. …”
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    Insight into the RssB-Mediated Recognition and Delivery of σ(s) to the AAA+ Protease, ClpXP
  3. 123
    “…Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. …”
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    Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
  4. 124
    “…LONP1 and ClpP genes closely localized on chromosome 19 and were co-expressed at high levels in most human cancers. …”
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    LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
  5. 125
    “…Based on the combination of altered processing patterns, protein accumulation and stabilization in CLPP-deficient mice and interaction with CLPP, we identified OAT, HSPA9 and POLDIP2 and as novel bona fide ClpXP substrates. Finally, we propose that ClpXP participates in the cooperative degradation of UQCRC1. …”
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    The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis
  6. 126
    “…This review focuses on the molecular chaperone ClpB that belongs to the Hsp100/Clp subfamily of the AAA+ ATPases and its biological function in selected bacterial pathogens, causing a variety of human infectious diseases, including zoonoses. …”
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    Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens
  7. 127
    “…CLP is a novel hybrid peptide derived from CM4, LL37 and TP5, with significantly reduced hemolytic activity and increased antibacterial activity than parental antimicrobial peptides. …”
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    Expression, Purification and Characterization of a Novel Hybrid Peptide CLP with Excellent Antibacterial Activity
  8. 128
    “…On the other hand, highly negatively correlated with the expression of mast cells. In short, CLP1 may play a non-negligible role in the onset and development of RA by altering immune cell infiltration, and it is predicted to represent a novel target for RA clinical diagnosis and therapy.…”
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    CLP1 is a Prognosis-Related Biomarker and Correlates With Immune Infiltrates in Rheumatoid Arthritis
  9. 129
    “…We hypothesize that ClpX functions in chlamydial differentiation through targeted protein degradation. …”
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    Tag-Dependent Substrate Selection of ClpX Underlies Secondary Differentiation of Chlamydia trachomatis
  10. 130
    “…Aberrant activation of  bacterial ClpP is an alternative method of discovering antibiotics, while it remains difficult to develop selective  Staphylococcus aureus ClpP activators that can avoid disturbing Homo sapiens ClpP functions. …”
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    Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP
  11. 131
    “…The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen. ClpC1, the unfoldase component of the essential ClpC1P1P2 protease, has emerged as one particularly promising antibacterial target. …”
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    Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1
  12. 132
    “…The stress responses and bacterial virulence of various pathogenic bacteria are associated with the ATP-dependent Clp protease. In this study, a Brucella abortus 2308 strain, ΔclpP, was constructed to characterize the function of ClpP peptidase. …”
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    ClpP protease modulates bacterial growth, stress response, and bacterial virulence in Brucella abortus
  13. 133
    “…BACKGROUND: Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the replication phase to the transmission phase. ClpP, the catalytic core of the Clp proteolytic complex, is widely involved in many cellular processes via the regulation of intracellular protein quality. …”
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    The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila
  14. 134
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    Effects of intraperitoneal immunoglobulin therapy on behavior and cognitive functions in CLP-induced sepsis model in rats
  15. 135
    por Kitamura, Kenji
    Publicado 2014
    “…The type 1 and type 2 residues bind to the UBR box and the ClpS/N-domain, respectively, in canonical Ubr ubiquitin ligases that act as N-recognins. …”
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    The ClpS-like N-domain is essential for the functioning of Ubr11, an N-recognin in Schizosaccharomyces pombe
  16. 136
    “…The ClpB chaperone is known to be involved in bacterial stress response. …”
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    The Symbiotic Performance of Chickpea Rhizobia Can Be Improved by Additional Copies of the clpB Chaperone Gene
  17. 137
    “…A negative cytoskeleton organization regulator, CLP36, was found to be accumulated in Atg7-deficient cardiomyocytes. …”
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    Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36
  18. 138
    “…To determine the role of specific Clp and FtsH subunits in plant growth and development, RNAi lines targeting at least one subunit of each Clp ring and FtsH were generated in tobacco. …”
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    Generation and characterization of a collection of knock-down lines for the chloroplast Clp protease complex in tobacco
  19. 139
    “…In the present study, two different rat models of sepsis, cecal ligation and puncture (CLP), and lipopolysaccharide (LPS), were established. …”
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    A comparative study of changes of autophagy in rat models of CLP versus LPS induced sepsis
  20. 140
    “…Plasmid-borne ClpL is thus a potential predictor of elevated heat resistance in L. monocytogenes. …”
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    Heat Resistance Mediated by pLM58 Plasmid-Borne ClpL in Listeria monocytogenes
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