Mostrando 1,381 - 1,400 Resultados de 2,845 Para Buscar '"CLP"', tiempo de consulta: 0.25s Limitar resultados
  1. 1381
    “…Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α(2A)-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced septic rats were treated with BRL44408 (α(2A)-AR antagonist), prazosin (α(1)-AR antagonist) and/or reserpine. …”
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    α(2A)-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
  2. 1382
    “…We tested if the administration of AuNP, as an adjuvant to antibiotics, could attenuate bacterial sepsis in cecal ligation and puncture (CLP) mouse model with antibiotic (imipenem/cilastatin). …”
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    Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization
  3. 1383
    “…Additionally, the polytrauma hit was followed by cecal ligation and puncture (CLP) 48 h later and compared to CLP alone. Splenectomy improved the 28-day survival in secondary sepsis to 92% (from 62%), while TH lowered it to 46% (p < 0.05). …”
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    Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis
  4. 1384
    “…Methods: Limb rIPC was conducted on mice in vivo 24 h before the onset of cecal ligation and puncture (CLP), and serum exosomes derived from rIPC mice were infused into CLP-challenged recipients. …”
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    Delayed Remote Ischemic Preconditioning ConfersRenoprotection against Septic Acute Kidney Injury via Exosomal miR-21
  5. 1385
    “…Sepsis was induced in C57BL/6 wild-type (WT) and CIRP(−/−) mice by cecal ligation and puncture (CLP). After 20 h of CLP induction, NETs in the lungs of WT and CIRP(−/−) mice were quantified by flow cytometry by staining the single cell suspensions with MPO and CitH3 Abs. …”
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    Cold-inducible RNA-binding Protein Induces Neutrophil Extracellular Traps in the Lungs during Sepsis
  6. 1386
    “…In this study, we evaluated the early outcome-dependent immuno-inflammatory response in humanized mice generated in the NSG strain after cecal ligation and puncture (CLP) sepsis. Mice were observed for 32 h post-CLP and were assigned to either predicted-to-die (P-DIE) or predicted-to-survive (P-SUR) groups for retrospective comparisons. …”
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    The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome
  7. 1387
    “…Consequently, rLcn-2 improved LPS tolerance only in FcGRIIb-/- macrophages and attenuated disease severity of cecal ligation and puncture (CLP) sepsis pre-conditioning with sequential LPS injection (LPS-CLP model) only in FcGRIIb-/- mice, but not in WT mice. …”
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    Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice
  8. 1388
    “…MiR-495 and SOFA score were better indictors for the occurrence of cardiac dysfunction in sepsis patients. In CLP-induced sepsis model. CLP rats experienced deterioration of LVSP, LVEDP, ± dp/dt(max), and had a rise in serum CTn-I, CK-MB, TNF-α, IL-6 and IL-1β, which were improved by miR-495 agomir injection. …”
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    MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction
  9. 1389
    “…Septic stress was induced by cecal ligation and puncture (CLP), and gut permeability was detected by tracer fluorescein isothiocyanate–dextran assays. …”
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    Long Noncoding RNA H19 Impairs the Intestinal Barrier by Suppressing Autophagy and Lowering Paneth and Goblet Cell Function
  10. 1390
    “…Imipridones represent a novel approach to therapeutically target previously undruggable GPCRs, ClpP, and innate immune pathways in oncology.…”
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    ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
  11. 1391
    “…Both circulating and lung midkine was increased in CLP mouse, and was related to severe lung injury. …”
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    Pulmonary midkine inhibition ameliorates sepsis induced lung injury
  12. 1392
    “…Analysis of GzmA in lymphoid cells following CLP showed that it was mainly expressed by NK cells. …”
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    Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
  13. 1393
    “…Furthermore, Clp directly interacts with LchD and enhances its diguanylate cyclase activity. …”
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    Coordinated control of the type IV pili and c‐di‐GMP‐dependent antifungal antibiotic production in L ysobacter by the response regulator PilR
  14. 1394
    “…Recombinant IL-35 improved survival in a murine model of CLP-induced ARDS. Additionally, IL-35 administration decreased the inflammatory response, as reflected by lower levels of cytokines (including IL-2, TNF-α, IL-1β and IL-6) and less lung damage in CLP-induced ARDS. …”
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    Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios(+)Foxp3(+) Tregs in clinical and experimental acute respiratory distress syndrome
  15. 1395
    “…OBJECTIVE AND DESIGN: Fecal calprotectin (CLP) is widely known for its detection in stools of patients with inflammatory bowel diseases (IBDs), to investigate the intestinal inflammatory status. …”
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    Circulating calprotectin as a supporting inflammatory marker in discriminating SARS-CoV-2 infection: an observational study
  16. 1396
    “…The estimated dVal:dLys for body weight gain was found to be 0.68 (EA, 95% of maximum response) and 0.67 (CLP) in the starter phase and 0.65 (EA, 95% of maximum response and CLP) in the total trial period. …”
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    The Optimal Valine to Lysine Ratio for Performance Parameters in Weaned Piglets
  17. 1397
    “…In addition, EtOH could activate the SphK1/S1P/S1PR1 pathway in CLP mice. However, PF-543, as a specific inhibitor of SphK1, could partially reverse the deleterious effects on lung injury of CLP mice. …”
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    Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice
  18. 1398
    por Xu, Hai-Ping, Ma, Xiao-Ying, Yang, Chen
    Publicado 2021
    “…We observed that circTLK1 expression was elevated in the cecal ligation and puncture (CLP) rat model compared with that in the control rats. …”
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    Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis
  19. 1399
    “…Grades were similar regardless of laterality of cleft lip (CLO or CLP). CONCLUSION: In Norway, individuals born with isolated CLO or CLP did not have lower average school grades when graduating from middle school. …”
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    Isolated oral clefts and school grades: population-based cohort study from Norway
  20. 1400
    “…Cecal ligation and perforation (CLP) were used to construct a mouse model of gut-origin sepsis. …”
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    Lentinan Attenuates Damage of the Small Intestinal Mucosa, Liver, and Lung in Mice with Gut-Origin Sepsis
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