“…We discovered that OIP5-AS1 and Sirtuin1 (SIRT1) were markedly down-regulated in sepsis models elicited by CLP or LPS, while miR-128-3p experienced a dramatic up-regulation. …”
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“…ONC201 significantly suppressed tumor growth, and decreased serum VEGF production in obese and lean mice, leading to a decrease in tumoral expression of Ki-67, VEGF and phosphorylation of p42/44 and S6 and an increase in ClpP and DRD5, as assessed by immunohistochemistry. …”
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“…Therefore, we evaluated the role of GABA type A receptor (GABAAR) agonist (muscimol), KCC2 enhancer (CLP257) in remifentanil-induced hyperalgesia, as well as GABA and KCC2 receptors responses in the dorsal spinal horn. …”
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“…Here, FABP4 was mainly upregulated in renal tubular epithelial cells (RTECs) following cecal ligation and puncture (CLP)- or lipopolysaccharide (LPS)-induced septic AKI. …”
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“…Progression of seed aging was associated with the decreased transcript levels of most of the analyzed genes (Lea1, Lea2a, Lea4, Hsp70b, Hsp20a, Hsp20b, ClpB1, ClpB4, Cpn60a, Cpn60b, Raptor, and Saur). …”
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“…Furthermore, in vivo results demonstrated that NaHS attenuated CLP-induced septic myocardial ferroptosis and significantly improved cardiac dysfunction in septic rats compared with the CLP group. …”
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“…Sepsis was induced by cecal ligation and puncture (CLP). At 24 h after surgery, brain tissue was sampled. …”
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“…The Congruence Lattice Problem (CLP), stated by R. P. Dilworth in the forties, asks whether every distributive {∨, 0}-semilatticeS is isomorphic to the semilattice Conc L of compact congruences of a lattice L. …”
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“…Our data provide new insight into CLP function in tumors and identifies specific targets for tumor control.…”
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“…Here, we show that loss of the transcription factor E47 produces a reduced CLP population that lacks V(D)J recombinase activity and D-J(H) rearrangements in vivo. …”
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“…Therefore, we evaluated complement function by measuring complement hemolytic activity (CH50) in various animal models of isolated ischemia reperfusion (I/R: kidney, liver, gut), hemorrhagic traumatic shock (HTS), endotoxic shock (LPS), and sepsis (CLP). Complement activation was less pronounced in isolated models of ischemia and reperfusion, whereas a strong complement response was observed early after HTS, CLP, and LPS. …”
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“…The complement lectin pathway (CLP) was discovered in 1990. These new components at the complement world are very efficient. …”
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“…This will enable manufacturers and blenders to apply the CLP and GHS criteria for the classification of mineral products containing RCS a fine fraction of CS.…”
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“…We simulate the pathophysiology of severe burn trauma and burn-induced sepsis, using rat models of experimental burn injury and cecal ligation and puncture (CLP) either individually (singe-hit model) or in combination (double-hit model). …”
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“…Both the cecal ligation and puncture (CLP) and lipopolysacharide (LPS) models of sepsis induce the expression of EST and compromise the activity of estrogen, an anti-inflammatory hormone. …”
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“…Further experiments showed that the apoptosis of CLP decreased, but proliferation was not altered in miR-128-2-overexpressed mice. …”
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“…Corresponding results were found in CLP, where we observed an improved capacity for enriched animals to clear systemic microbial infection. …”
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“…Patients with cleft lip and palate (CLP) must undergo corrective surgeries during infancy and early childhood. …”
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“…Here, we utilized a cecal ligation and puncture (CLP) method in mice with the goal of creating a model that concurrently displays all the characteristics of PICS. …”
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“…We use a physiologically based pharmacokinetic (PBPK) workflow to assess the accuracy of linear scaling of plasma clearance (CLp) for hypothetical drugs with ranges of realistic parameter values in pediatric patients of different ages. …”
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