Mostrando 141 - 160 Resultados de 2,845 Para Buscar '"CLP"', tiempo de consulta: 0.83s Limitar resultados
  1. 141
    “…B. subtilis cells cultured under different nutrient conditions indicate that UgtP accumulation is controlled through a nutrient-dependent post-translational mechanism dependent on the Clp proteases. Notably, all three B. subtilis Clp chaperones appeared able to target UgtP for degradation during growth in nutrient-poor conditions. …”
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    A nutrient-dependent division antagonist is regulated post-translationally by the Clp proteases in Bacillus subtilis
  2. 142
    “…METHODS: Cecal ligation and puncture (CLP) or sham operation (SHAM) was performed in rats. …”
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    Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats
  3. 143
    “…Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6–12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10–12 week old) and aged (16–18 month old) mice against polymicrobial infection, organ dysfunction, and death. …”
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    Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis
  4. 144
    “…Affinity chromatography/drug competition assays showed that the TR compounds bound ClpP with ∼10-fold higher affinity compared to ONC201. …”
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    Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
  5. 145
    “…Moreover, we find that αSyn WT and A53T mutant interact with ClpP and suppress its peptidase activity. The binding of αSyn to ClpP further promotes a distribution of ClpP from soluble to insoluble cellular fraction in vitro and in vivo, leading to reduced solubility of ClpP. …”
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    Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
  6. 146
    “…The stationary phase promoter specificity subunit σ(S) (RpoS) is delivered to the ClpXP machinery for degradation dependent on the adaptor RssB. …”
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    Structural basis for inhibition of a response regulator of σ(S) stability by a ClpXP antiadaptor
  7. 147
    “…In the total absence of LSU, attenuation of ClpP leads to a dramatic stabilization of unassembled SSU, indicating that Clp is responsible for its degradation. …”
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    Role of ClpP in the Biogenesis and Degradation of RuBisCO and ATP Synthase in Chlamydomonas reinhardtii
  8. 148
    “…LonA proteases and ClpB chaperones are key components of the protein quality control system in bacterial cells. …”
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    New insights into structural and functional relationships between LonA proteases and ClpB chaperones
  9. 149
    “…Previously, we determined the Staphylococcus aureus HSP ClpC temporally alters bacterial metabolism and persistence. …”
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    ClpC affects the intracellular survival capacity of Staphylococcus aureus in non-professional phagocytic cells
  10. 150
    “…Bacterial ClpP is a highly conserved, cylindrical, self-compartmentalizing serine protease required for maintaining cellular proteostasis. …”
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    ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
  11. 151
    “…A clpP deletion mutant (△clpP) was constructed using the E. faecalis OG1RF strain to clarify the effect of ClpP on E. faecalis. …”
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    ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis
  12. 152
    “…The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. …”
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    A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery
  13. 153
    “…In our study, we investigate the effects of oroxylin A on sepsis in cecal ligation and puncture (CLP) mice. We find that the 60 h + 84 h (30 mg/kg) injection scheme of oroxylin A induce the production of pro-inflammatory factors, and further significantly improves the survival of CLP mice during the middle or late stages of sepsis. …”
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    Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15
  14. 154
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    Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
  15. 155
    “…This study investigated evolutionary relationship and expression of ClpB/Hsp100 gene family in tomato under heat stress. …”
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    Phylogenetic and expression dynamics of tomato ClpB/Hsp100 gene under heat stress
  16. 156
    “…Moreover, our proteomic data indicated that the ClpX(V78F) mutation elevated the stability of known ClpXP targets to various degrees with FlhD as one of the most affected. …”
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    Gain of Spontaneous clpX Mutations Boosting Motility via Adaption to Environments in Escherichia coli
  17. 157
    “…This study provides a strong foundation for discovery of substrate selection by the chloroplast CLP protease system.…”
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    Proteomics, phylogenetics, and coexpression analyses indicate novel interactions in the plastid CLP chaperone-protease system
  18. 158
    por Mabanglo, Mark F., Houry, Walid A.
    Publicado 2022
    “…ATPase chaperones such as ClpX and ClpA are hexameric ATPases that form larger complexes with ClpP and are responsible for the selection and unfolding of protein substrates prior to their degradation by ClpP. …”
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    Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
  19. 159
    “…We have identified a novel synthetic lethal interaction between ClpP activation and HDAC1/2 inhibition that converges on GBM energy metabolism. …”
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    Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma
  20. 160
    “…We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ONC201. …”
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    Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
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