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  1. 21
    por Seo, Yeon-Soo, Kang, Young-Hoon
    Publicado 2018
    “…In addition, current efforts made to identify small molecules inhibiting the CMG helicase to develop anti-cancer therapeutic strategies were summarized, with new perspectives to advance the discovery of the CMG-targeting drugs.…”
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    The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy
  2. 22
    “…This suggests that Polε modulates CMG to pause at these sites.…”
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    DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier
  3. 23
    “…Myc interactors GCN5, Tip60, and TRRAP are essential for chromatin unfolding and recruitment of Cdc45, and co-expression of GCN5 or Tip60 with MBII-deficient Myc rescues these events and promotes CMG activation. Finally, Myc and Cdc45 interact and physiologic conditions for CMG assembly require the functions of Myc, MBII, and GCN5 for Cdc45 recruitment and initiation of DNA replication.…”
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    Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases
  4. 24
    “…When converging replication forks meet during replication termination, the CMG (Cdc45–MCM2–7–GINS) helicase is polyubiquitylated by CRL2(Lrr1) and unloaded from chromatin by the p97 ATPase. …”
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    The DNA replication fork suppresses CMG unloading from chromatin before termination
  5. 25
    “…L. mesenteroides CMG713 produced maximum dextran after 20 hours of incubation at 30ºC with 15% sucrose at pH 7.0. …”
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    Production & Characterization of a Unique Dextran from an Indigenous Leuconostoc mesenteroides CMG713
  6. 26
    “…The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. …”
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    DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
  7. 27
    “…ANTXR 1 and 2, also known as TEM8 and CMG2, are two type I membrane proteins, which have been extensively studied for their role as anthrax toxin receptors, but with a still elusive physiological function. …”
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    Differential Dependence on N-Glycosylation of Anthrax Toxin Receptors CMG2 and TEM8
  8. 28
    “…Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase, which unwinds the parental DNA duplex at eukaryotic replication forks, is the key regulated step during replication termination but is poorly understood [1, 2]. …”
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    Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase
  9. 29
    “…Fork reversal fails when CMG unloading is inhibited, but it does not require FANCI-FANCD2. …”
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    Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading
  10. 30
    “…Four isoforms of CMG2 have been described so far, one secreted in the serum as soluble CMG2 (sCMG2). …”
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    Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma
  11. 31
    “…In the eukaryotic replisome, DNA unwinding by the Cdc45-MCM-Go-Ichi-Ni-San (GINS) (CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome maintenance (MCM), which spools single-stranded DNA through its central channel. …”
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    Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome
  12. 32
    por Devbhandari, Sujan, Remus, Dirk
    Publicado 2020
    “…Importantly, we find that the Rad53 kinase restricts excessive DNA unwinding at replication forks by limiting CMG helicase activity, suggesting a mechanism for fork-stabilization by the replication checkpoint.…”
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    Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks
  13. 33
    “…The eukaryotic replisome, organized around the Cdc45-MCM-GINS (CMG) helicase, orchestrates chromosome replication. …”
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    Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork
  14. 34
    “…Here, we demonstrate that engagement of the eukaryotic CMG helicase with template DNA at the replication fork impairs its helicase activity, which is alleviated by binding of the single-stranded DNA binding protein, RPA, to the excluded DNA strand. …”
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    Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
  15. 35
    “…We show here the molecular mechanism by which CMG (GAN–MCM–GINS)-like helicase cooperates with the family D DNA polymerase (PolD) in Thermococcus kodakarensis. …”
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    Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome
  16. 36
    “…Critically, Pol α and the CMG helicase share a common mechanism of interaction with Ctf4. …”
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    A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
  17. 37
    “…CMG2-Fc is a fusion protein composed of the extracellular domain of capillary morphogenesis protein 2 (CMG2) and the Fc region of human immunoglobulin G; CMG2-Fc neutralizes anthrax toxin and offers protection against Bacillus anthracis challenge. …”
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    Improving the Anti-Toxin Abilities of the CMG2-Fc Fusion Protein with the Aid of Computational Design
  18. 38
    “…The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. …”
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    CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
  19. 39
    “…Hyaline fibromatosis syndrome is due to mutations of the gene-encoding capillary morphogenesis protein 2 (CMG2). Cases have been reported in different countries but to the best of our knowledge, this is the first reported Moroccan patient with hyaline fibromatosis syndrome and carrying the CMG2 mutation. …”
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    Hyaline fibromatosis syndrome with mutation c.1074delT of the CMG2 gene: a case report
  20. 40
    “…We found that, upon fork collapse, the active CDC45–MCM–GINS (CMG) helicase complex loses its GINS subunit. A functional replisome is restored by the reloading of GINS and Pol epsilon onto DNA in a RAD51- and MRE11- dependent manner, but independently of replication origin assembly and firing. …”
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    RAD51 and MRE11 dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks
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