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  1. 1
    “…DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG) helicase. Although the CMG architecture has been elucidated, its mechanism of DNA unwinding and replisome interactions remain poorly understood. …”
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    CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes
  2. 2
    “…The human CMG helicase (Cdc45-MCM-GINS) is a novel target for anti-cancer therapy due to tumor-specific weaknesses in CMG function induced by oncogenic changes and the need for CMG function during recovery from replicative stresses such as chemotherapy. …”
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    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
  3. 3
    “…CMG is also the organizing center of the replisome. …”
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    The eukaryotic CMG helicase pumpjack and integration into the replisome
  4. 4
    “…The CMG helicase is composed of Cdc45, Mcm2-7 and GINS. …”
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    Structure of the eukaryotic replicative CMG helicase and pumpjack motion
  5. 5
    por Maurice, G. T. K.
    Publicado 1918
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    Letter from Colonel Maurice, C.M.G.
  6. 6
    “…The synthetic function‐spacer‐lipid (FSL) amphiphile biotin‐CMG‐DOPE is widely used for delicate ligation of living cells with biotin residues under physiological conditions. …”
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    Structure of Supramers Formed by the Amphiphile Biotin‐CMG‐DOPE
  7. 7
    por Reed, Damon R., Alexandrow, Mark G.
    Publicado 2020
    “…Myc-driven tumorigenesis involves a non-transcriptional role for Myc in over-activating replicative Cdc45-MCM-GINS (CMG) helicases. Excessive stimulation of CMG helicases by Myc mismanages CMG function by diminishing the number of reserve CMGs necessary for fidelity of DNA replication and recovery from replicative stresses. …”
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    Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer
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    DONSON is required for CMG helicase assembly in the mammalian cell cycle
  9. 9
    “…Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential biological function, its biochemical role in DNA replication has remained elusive. …”
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    Structure of human Cdc45 and implications for CMG helicase function
  10. 10
    “…The eukaryotic replicative CMG (Cdc45, Mcm2-7, GINS) helicase contains a Mcm2-7 motor ring, with the N-tier ring in front and the C-tier motor ring behind. …”
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    DNA unwinding mechanism of a eukaryotic replicative CMG helicase
  11. 11
    “…Activation occurs after the recruitment of a set of firing factors that assemble two Cdc45–MCM–GINS (CMG) holo-helicases. CMG formation leads to the underwinding of DNA on the path to the establishment of the replication fork, but whether DNA becomes melted at this stage is unknown(1). …”
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    Mechanism of replication origin melting nucleated by CMG helicase assembly
  12. 12
    “…RESULTS: The CMG-biotools system presents a stand-alone interface for comparative microbial genomics. …”
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    CMG-Biotools, a Free Workbench for Basic Comparative Microbial Genomics
  13. 13
    “…The recombinant, soluble von Willebrand factor type A (vWA) domain of CMG2 (sCMG2) has demonstrated potency against anthrax toxin. …”
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    Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor
  14. 14
    Publicado 1904
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    The Late Deputy Surgeon-General H. Cayley, C.M.G.
  15. 15
    “…Genome duplication is safeguarded by constantly adjusting the activity of the replicative CMG (CDC45-MCM2-7-GINS) helicase. However, minichromosome maintenance proteins (MCMs)—the structural core of the CMG helicase—have never been visualized at sites of DNA synthesis inside a cell (the so-called MCM paradox). …”
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    Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes
  16. 16
    “…The replisome that replicates the eukaryotic genome consists of at least three engines: the Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and two DNA polymerases, one on each strand, that replicate the unwound DNA. …”
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    Synergism between CMG helicase and leading strand DNA polymerase at replication fork
  17. 17
    por Hatcher, Jeff
    Publicado 2009
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    Using short-stay trim points to identify potential CMG design improvements
  18. 18
    “…These findings suggest that CMG2 may be used to stabilize PA in future anthrax vaccines.…”
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    Long-Range Stabilization of Anthrax Protective Antigen upon Binding to CMG2
  19. 19
    “…Although Mcm2–7 activation requires binding of the helicase-activating proteins Cdc45 and GINS (forming the CMG complex), an additional protein, Mcm10, drives initial origin DNA unwinding by an unknown mechanism. …”
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    Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase
  20. 20
    “…CMG2 promotes endothelial cell proliferation and exhibits angiogenic properties. …”
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    CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients
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