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  1. 26561
    “…BACKGROUND: Despite its clinical usefulness, the use of tetracycline antibiotics (TCs) in children has historically been limited because of the risk of permanent tooth discoloration and enamel deformity, although age restrictions have varied across countries (e.g., contraindicated under 8 years of age in Taiwan, USA, and Canada, and under 12 years of age in Korea and UK). …”
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    2149. Risk of dental abnormalities after tetracycline exposure in children: A retrospective, population-based study in Korea, 2003-2015
  2. 26562
    “…METHODS: This study examined the delivery of four virtual parent-led peer support groups in Ontario, Canada for parents of children with EDs with approximately 10 parent participants per group and two parent facilitators leading each group. …”
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    “I’m not alone”: a qualitative report of experiences among parents of children with eating disorders attending virtual parent-led peer support groups
  3. 26563
    “…A national unified approach is warranted in establishing guidelines for dental hygiene practice in Canada. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12913-022-08925-z.…”
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    Canadian dental hygienists’ experiences and perceptions of regulatory guidelines during the COVID-19 pandemic: a qualitative descriptive analysis
  4. 26564
    “…METHODS: Fecal samples were collected from healthy controls (N = 62) and CRC patients (N = 94) from the province of Québec (Canada), and a bacterial DNA extraction was performed. …”
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    Prevalence of pks + bacteria and enterotoxigenic Bacteroides fragilis in patients with colorectal cancer
  5. 26565
    “…METHODS: A parallel arm double-blind randomized controlled pilot trial conducted at two EDs in Canada. Eligible participants were adults (age ≥ 18 years) presenting to the ED with non-purulent cellulitis and determined by the treating emergency physician to be eligible for outpatient management with oral antibiotics. …”
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    High-dose cephalexin for cellulitis: a pilot randomized controlled trial
  6. 26566
    “…METHODS: TAY (aged 16–20 years) with co-occurring chronic health and mental health conditions were recruited in Alberta, Canada. Nine semi-structured individual interviews were completed by phone or videoconference, and transcribed verbatim. …”
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    “They go hand in hand”: a patient-oriented, qualitative descriptive study on the interconnectedness between chronic health and mental health conditions in transition-age youth
  7. 26567
    “…Positive-pressure ventilation was instituted for 4-h using a FlexiVent (Flexiware 8.1, Scireq, Montreal, QC, Canada). Lipopolysaccharide (Salmonella enterica serotype tryphimurium L6143, Millipore Sigma) was administered via an intratracheal (IT) route at a dose of 0.1 mg/kg. …”
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    Early mechanisms of neutrophil activation and transmigration in acute lung injury
  8. 26568
    “…With the high prevalence of concurrent mental health and substance use disorders in vulnerably-housed populations in Canada, it becomes increasingly important to advocate for increased guidance and research into treating concurrent disorders. …”
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    Varenicline induced auditory hallucinations in a young female with bipolar disorder: a case report
  9. 26569
    “…Matched general population data were obtained from Statistics Canada when available. RESULTS: Seventy-four (24% response rate) athletes (average age 45 (±9) years; retired 15 (±9) years) completed the questionnaire (30 rowing, 44 rugby athletes). …”
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    Beyond the medals: a cross-sectional study exploring retired elite female athletes’ health
  10. 26570
    “…METHODS: We performed a four-phase pragmatic mixed methods study recruiting PCPs and specialists from two public health systems located in two countries: eConsult BASE in Canada and San Francisco Health Network eConsult in the United States. …”
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    Development of eConsult reflective learning tools for healthcare providers: a pragmatic mixed methods approach
  11. 26571
    “…We conducted a single-arm, open-label phase II trial at the Princess Margaret Cancer Centre in Toronto, ON, Canada. Participants with advanced cancer with moderate to severe MDD received three flexible doses of intranasal (IN) ketamine (50–150 mg) over a one-week period. …”
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    A Phase II, Open-Label Clinical Trial of Intranasal Ketamine for Depression in Patients with Cancer Receiving Palliative Care (INKeD-PC Study)
  12. 26572
    “…This study took place in Alberta, Canada (from January 1, 2018, to December 31, 2019), and included all patients 18 years and older who received at least 1 opioid dispensation from a community pharmacy within the province. …”
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    Development and Validation of a Machine Learning Model to Estimate Risk of Adverse Outcomes Within 30 Days of Opioid Dispensation
  13. 26573
    “…DESIGN, SETTING, AND PARTICIPANTS: This multicenter, randomized, double-blind, placebo-controlled trial took place at 23 sites in Germany and Canada from January 2015 to January 2021. Adult cardiac surgery patients with a European System for Cardiac Operative Risk Evaluation II score–predicted mortality of 5% or more or planned combined surgical procedures were randomized. …”
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    Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial
  14. 26574
    “…SETTING: Entire province of Alberta, Canada. PARTICIPANTS: All adults in Alberta with eGFR defined CKD G3 or greater between 2009 and 2017 were included. …”
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    Population-Based Analysis of Nonsteroidal Anti-inflammatory Drug Prescription in Subjects With Chronic Kidney Disease
  15. 26575
    “…BACKGROUND: In Canada, Ontario Health Teams (OHTs) are a new model for integrated healthcare. …”
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    Family physicians collaborating for health system integration: a scoping review
  16. 26576
    “…DESIGN, SETTING, AND PARTICIPANTS: In this parallel-arm multicenter randomized clinical trial at 2 tertiary ERCP centers in Canada, all patients 18 years and older and undergoing ERCP for any indication were eligible. …”
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    Effect of Disposable Elevator Cap Duodenoscopes on Persistent Microbial Contamination and Technical Performance of Endoscopic Retrograde Cholangiopancreatography: The ICECAP Randomized Clinical Trial
  17. 26577
    “…SETTING: The setting for this case study was the province of Quebec, Canada. PARTICIPANTS: Thirty-two key stakeholders from all levels of the health system. …”
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    Living Donor Kidney Transplantation in Quebec: A Qualitative Case Study of Health System Barriers and Facilitators
  18. 26578
    “…ETHICS AND DISSEMINATION: The study was approved by Health Canada and the Research Ethics Boards of the McGill University Health Centre (MUHC-REB, protocol number: MP37-2022-8295). …”
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    Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study
  19. 26579
    “…However, characterization of the real-world effectiveness of guselkumab among patients living in the USA and Canada is warranted. METHODS: Patients who participated in the CorEvitas Psoriasis Registry between 18 July 2017 and 10 March 2020 were included if they met the following criteria: Investigator’s Global Assessment (IGA) score ≥ 3 and body surface area (BSA) ≥ 10% (moderate-to-severe psoriasis), initiated guselkumab at a registry (index) visit, and had a registry follow-up visit after 9–12 months of persistent guselkumab therapy. …”
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    Real-World Effectiveness of 9–12 Months of Guselkumab Therapy among Patients with Moderate-to-Severe Plaque Psoriasis in the CorEvitas Psoriasis Registry
  20. 26580
    “…METHODS: This study included longitudinal data from the “Alberta's Tomorrow Project”—a province-wide cohort study (Alberta, Canada). The analysis included data collected at two time points (i.e., baseline and follow-up) from 5,977 urban adults. …”
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    Associations between neighborhood walkability and walking following residential relocation: Findings from Alberta's Tomorrow Project
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