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  1. 27281
    “…All relevant Dutch HTA-reports, published between 2017 and 2019, were selected and matched with HTA-reports from three other jurisdictions (England, Canada, Australia). Information was extracted. Additionally, reimbursement reports for three cases of expensive non-oncolytic orphan drugs prominent in pricing debates in the Netherlands were investigated in depth to examine consideration of profit margins. …”
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    Do Health Technology Assessment organisations consider manufacturers’ costs in relation to drug price? A study of reimbursement reports
  2. 27282
    “…With the intention of investigating and supporting a growing citizen-led COS in a green building, this study applied an empowerment-based Photovoice method in the context of the HPGB evolv1, located in Waterloo, Ontario, Canada. Six building users (citizens) took and selected photographs, participated in facilitated group discussions and individual interviews, and contributed toward three public exhibitions based on research findings. …”
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    Co-creating cultures of sustainability and co-imagining the teaching green building: the use of a participatory Photovoice process in a HPGB context
  3. 27283
    “…In this study, the SARS-CoV-2 wastewater signal to clinical cases (WC) ratio was investigated across seven cities in Canada over periods ranging from 8 to 21 months. This work demonstrates that significant increases in the WC ratio occurred when clinical testing eligibility was modified to appointment-only testing, identifying a period of insufficient clinical testing (resulting in a reduction to testing access and a reduction in the number of daily tests) in these communities, despite increases in the wastewater signal. …”
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    Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communities
  4. 27284
    “…METHODS: In this cross-sectional study, a self-explicated ‘conjoint analysis’ survey was administered online to eligible patients with wet AMD (receiving anti-vascular endothelial growth factor [VEGF] treatment for at least 12 months) from the USA, Canada, UK, France, Spain, Germany, Italy, Japan, Taiwan, and Australia. …”
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    Patient Preferences in the Management of Wet Age-Related Macular Degeneration: A Conjoint Analysis
  5. 27285
    “…The study was conducted at 56 centers in the US and Canada. Enrolled were participants from 60 to 85 years of age with gradual and progressive change in memory function for 6 months or more, early symptomatic Alzheimer disease, elevated amyloid, and intermediate tau levels. …”
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    Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial
  6. 27286
    “…This study will be conducted in a large inner-city homeless shelter within a major urban Canadian city (Calgary, Canada). DISCUSSION: Currently, screening for diabetes complications is often inaccessible for individuals experiencing homelessness, which places heavy burdens on individuals and, ultimately, on already strained emergency and acute care services when complications go undetected at earlier stages. …”
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    Developing and evaluating a SAFER model to screen for diabetes complications among people experiencing homelessness: a pilot study protocol
  7. 27287
    “…Only two publications were from lower- and middle-income countries (Nigeria, Mexico), and the remaining 14 were from high-income countries (Italy, Denmark, USA, Australia, and New Zealand, Japan, Switzerland, Canada). The data management systems found in this study were as follows: Virtopsy, Canadian Coroner and Medical Examiner Database, Infant Injury Database, Fatal injury surveillance system, Medical Examiners and Coroners Alert System, National Violent Deaths Reporting System, AM/PM Database, Tokyo CDISC/ODM, and National Coronial Information System. …”
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    Introductory evidence on data management and practice systems of forensic autopsies in sudden and unnatural deaths: a scoping review
  8. 27288
    “…We developed a pan-amdoparvovirus PCR and screened tissue samples from 666 wild carnivores (families Felidae, Canidae, and Mustelidae) from Newfoundland or Labrador (Canada) and molecularly characterized the identified strains. …”
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    Multi-host dispersal of known and novel carnivore amdoparvoviruses
  9. 27289
    “…Concomitantly, regulatory frameworks designed to assess corresponding pesticide risks in Canada and the USA have become increasingly more stringent and intensive. …”
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    Human induced fish declines in North America, how do agricultural pesticides compare to other drivers?
  10. 27290
    “…METHODS: Motivated by an observed unique pattern of engagement in patients enrolled in our Medly HF management program at the Peter Munk Cardiac Centre in Toronto, Canada, we conducted 20 semistructured interviews with a convenience sample of ICs. …”
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    The Value of Technology to Support Dyadic Caregiving for Individuals Living With Heart Failure: Qualitative Descriptive Study
  11. 27291
    “…OBJECTIVE: The objective of this study is to show how publicly available data sources, including the provincial physician license registry, can be used to generate a verifiable, region-wide list of primary care clinics in British Columbia, Canada, using a process named the Clinic List Algorithm (CLA). …”
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    Finding Primary Care—Repurposing Physician Registration Data to Generate a Regionally Accurate List of Primary Care Clinics: Development and Validation of an Open-Source Algorithm
  12. 27292
    “…METHODS: This multicenter, open-label, 26-week phase 3 trial took place at 28 sites across 4 countries (Australia, Canada, New Zealand, and the USA). The trial enrolled 146 children with GHD, 143 of which were previously treated with daily somatropin. …”
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    Switching to Weekly Lonapegsomatropin from Daily Somatropin in Children with Growth Hormone Deficiency: The fliGHt Trial
  13. 27293
    “…Lastly, broader feedback from HTA researchers across Canada was sought and incorporated into the final guidance. …”
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    Guidance on review type selection for health technology assessments: key factors and considerations for deciding when to conduct a de novo systematic review, an update of a systematic review, or an overview of systematic reviews
  14. 27294
    “…METHODS: This study was conducted in Kingston, Ontario, Canada, from September 2019 to August 2021. A workshop and 2 questionnaires were used to understand the benefits of and barriers to implementing the questionnaire in clinical settings. …”
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    Implementation of a Work-Related Asthma Screening Questionnaire in Clinical Settings: Multimethods Study
  15. 27295
    “…This research is ongoing in long-term care (LTC) homes in western Canada. TREC data include the following: 5 waves of survey collection, 2 clinical trials, and regular ongoing outcome data for LTC residents. …”
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    The Influence of Context on Implementation and Improvement: Protocol for a Mixed Methods, Secondary Analyses Study
  16. 27296
    “…METHODS: The study involved semi-structured interviews with 24 service providers within the anti-violence sector in Alberta, Canada working with and serving individuals affected by IPV. …”
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    Perspectives on delivering safe and equitable trauma-focused intimate partner violence interventions via virtual means: A qualitative study during COVID-19 pandemic
  17. 27297
    “…In addition, a subset of SNPs was selected to represent rare and local alleles found in Eastern Canada which could be used for ecotype and population assignments - information urgently needed for conservation planning. …”
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    Design and validation of a 63K genome-wide SNP-genotyping platform for caribou/reindeer (Rangifer tarandus)
  18. 27298
    “…BACKGROUND: Implementing mental health recovery into services is a policy priority in Canada and globally. To that end, a 5 year study was undertaken with seven organisations providing mental health and housing services to people living with a mental health challenge to implement guidelines for the transformation of services and systems towards a recovery-orientation. …”
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    The impacts of implementing recovery innovations: a conceptual framework grounded in qualitative research
  19. 27299
    “…SETTING: Nine University affiliated ICUs in Canada. PATIENTS: Medical/surgical patients requiring MV for 7 or more days who were enrolled in the Towards RECOVER Study. …”
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    Association Between Tracheostomy and Functional, Neuropsychological, and Healthcare Utilization Outcomes in the RECOVER Cohort
  20. 27300
    “…DESIGN, SETTING, AND PARTICIPANTS: This diagnostic study was conducted at 47 hospitals across 7 provinces in Canada participating in the Canadian COVID-19 Rapid Response Emergency Department Network among consecutive eligible patients presenting to a participating emergency department who were tested for SARS-CoV-2 from March 1, 2020, to December 31, 2021. …”
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    Sensitivity and Diagnostic Yield of the First SARS-CoV-2 Nucleic Acid Amplification Test Performed for Patients Presenting to the Hospital
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